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Ofloxacin CAS 82419-36-1 and Levofloxacin Hemihydrate Raw material, API CAS 138199-71-0

Ofloxacin CAS 82419-36-1 and Levofloxacin Hemihydrate Raw material, API CAS 138199-71-0

Ofloxacin CAS 82419-36-1 and Levofloxacin Hemihydrate Raw material, API CAS 138199-71-0 Certificate of Analysis: Levofloxacin Hemihydrate Certificate of Analysis: Levofloxacin Hemihydrate

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Product Details

Ofloxacin CAS 82419-36-1 and Levofloxacin Hemihydrate Raw material, API CAS 138199-71-0                                           Ofloxacin base and Levofloxacin Hemihydrate Raw material, API.jpg

Product

Ofloxacin

Levofloxacin Hemihydrate

Synonyms:

Ofloxacinum, Ofloxacine

Levofloxacine

CAS

82419-36-1

138199-71-0

Appearance:

A pale yellow or bright yellow, crystalline   powder

Yellowish crystalline powder

Assay

98.5% ~ 101.5%

98.5% Min

Formula:

C18H20FN3O4

C18H20FN3O4·1/2H2O

Structure:

Ofloxacin base Raw material, API formula.gif

Levofloxacin Hemihydrate Raw material, API formula.jpg

Packing info

25Kg/Fiber DrumCardboard DrumPaper Drum

25Kg/Cardboard Drum

Description of Ofloxacin Raw Material, API:

With a chemical name 8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid, Ofloxacin Raw Material, API is an synthetic fluoroquinolones (quinolone) antibacterial Susbstance. Ofloxacin will target the bacteria in body system. Bacterial caused infections of the skin, lungs, prostate, or urinary tract (bladder and kidneys) are the main indications of Ofloxacin. Moreover Ofloxacin Raw Material, API is also used to cure or fight against pelvic inflammatory disease and Chlamydia and/or gonorrhea.

Ofloxacin Raw Material, API will interfere with the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

Ofloxacin will stop the bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two.

One thing we should pay special attention to is that Ofloxacin Raw Material, API has 100 times higher affinity for bacterial DNA gyrase than for mammalian. It will work against or target both Gram-positive and Gram-negative bacteria.

 

Ofloxacin Mechanism of Action:

Ofloxacin acts on DNA gyrase and toposiomerase IV, enzymes which will prevent the excessive supercoiling of DNA during replication or transcription. By interfere with this function, Ofloxacin will finally stop the cell division.

 

Ofloxacin Routine of Elimination in the body:

Ofloxacin elimination is mainly by the routine of renal excretion. About 65%-80% of an administered oral dosed ofloxacin will be excreted unchanged via the kidneys in about forty eight hours. 4%~8% percent ofloxacin will be excreted in the feces. This indicates a small degree of biliary excretion of ofloxacin.

--------------------------------

Description of Levofloxacin Hemihydrate Raw Material, API:

Levofloxacin Hemihydrate is a synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

Levofloxacin, a fluoroquinolone antiinfective, is the optically active L-isomer of ofloxacin. Levofloxacin is used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community-acquired pneumonia and pneumonia caused by penicillin-resistant strains ofStreptococcus pneumoniae, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis.

 

Levofloxacin Hemihydrate Indications:

Levofloxacin Hemihydrate is widely indicated for treating bacterial conjunctivitis caused by susceptible strains such as Corynebacterium species, Staphylococus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus (Groups C/F/G), Viridans group streptococci, Acinetobacter lwoffii, Haemophilus influenzae, Serratia marcescens, etc.

 

Levofloxacin Hemihydrate Mechanism of Action:

Levofloxacin Hemihydrate will inhibit bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Like other fluoroquinolones, Levofloxacin Hemihydrate interferes the A subunits of DNA gyrase. This process will lead to strand breakage on a bacterial chromosome, supercoiling, and resealing; As a result, DNA replication and transcription will get effected or even stopped.

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As a professional China Ofloxacin, Levofloxacin Hemihydrate Raw Material API supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Ofloxacin, Levofloxacin Hemihydrate Raw Material API from China for almost 10 years.


Certificate of Analysis: Levofloxacin Hemihydrate raw material, API

Name of product

Ofloxacin


Analytical items

Specifications

Analytical results

Characteristics

Ofloxacin

White or Light yellow green   crystalline powder

Complies

Identification

Ofloxacin

A: IR test

B:   UV test

Complies

Complies

Specific rotation

D20

-1°~+1°

+0.26°

Residual Solvents

A: Methanol

B: Ethanol

 

≤0.005%

≤0.05%

 

<0.005%

<0.05%

Purity test (HPIC)

A: Individual impurity

B: 9-desfluoroofloxacin

C: Total   impurity

 

≤0.3%

≤0.2%

≤0.5%

 

 

0.11%

0.09%

0.23%

Heavy metals

≤0.001%

<0.001%

Arsenic

≤1ug/g

Complies

Assay (on the dried basis)

≥98.5% Ofloxacin

99.2%

 

Certificate of Analysis: Levofloxacin Hemihydrate raw material, API

ITEMS

STANDARD

RESULTS

Appearance

Yellowish   crystalline powder (Levofloxacin Hemihydrate)

Yellowish   crystalline powder

Specific   optical rotation

-92°—   -99°

-97.2°

Identification    IR

IR   spectrum of sample conforms to that of reference standard.

complies

Identification    HPLC

The   retention time of the major peak in the chromatogram of the sample correspons   to that of reference standard. (Levofloxacin Hemihydrate)

complies

PH   of solution

6.8~7.6

7.0

Clarity   of solution

Clear   or its opalescence is not more pronounced than that of reference suspension   1.0

Clear

UV   absorbance

≤0.05

0.002

Water

2.1%~2.7%

2.7%

Impurity   A

≤0.2%

<0.2%

Impurity   B

≤0.2%

0.07%

Impurity   C

≤0.2%

Not   found

Any   other impurity

≤0.1%

0.05%

Sum   of impurities

≤0.5%

0.14%

R-ofloxacin

≤0.5%

0.22%

Ethanol

≤0.1%

0.062%

DMSO

≤0.1%

Not   found

Chloroform

≤0.006%

0.0057%

Residue   on ignition

≤0.1%

0.04%

Heavy   metals

≤10   ppm

3ppm

Assay   (on anhydrous basis)

98.0%~102.0%   C18H20FN3O4 Levofloxacin Hemihydrate

99.5%

 

Top Quality, Pure Ofloxacin, Levofloxacin Hemihydrate Powder;  Ofloxacin, Levofloxacin Hemihydrate Raw Material Suppliers in China. Ofloxacin, Levofloxacin Hemihydrate API Manufacturers. 

 

Related similar product you may interested:    

Ofloxacin CAS 82419-36-1 And Levofloxacin Hemihydrate Raw Material, API CAS 138199-71-0

Norfloxacin Nicotinate CAS 118803-81-9 And Norfloxacin Hydrochloride CAS 68077-27-0 And Norfloxacin Lactate CAS 97867-34-0




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Skype: frankrenful2002
E-Mail: frank_feng@fengchengroup.com
Tel: +86-186-7846 1007
WECHAT: +86-18678461007
WHATSAPP: +86-18678461007
Add: Room 1101, 5th Building, No.168 Shenzhen Road, Qingdao, China
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