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Colistin Sulfate or Colistin Sulphate API, Raw Material USP BP EP CAS 1264-72-8

Colistin Sulfate or Colistin Sulphate API, Raw Material USP BP EP CAS 1264-72-8

Colistin Sulfate or Colistin Sulphate API, Raw Material USP BP EP CAS 1264-72-8 Product Name: Colistin Sulfate (Colistin Sulphate) Synonyms: Colistini sulfas CAS Number: 1264-72-8 Characteristics: A white or almost white powder. Colistin Sulfate (Colistin Sulphate) is hygroscopic A mixture of the sulphates of...

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Colistin Sulfate or Colistin Sulphate API, Raw Material USP BP EP CAS 1264-72-8                                          Colistin Sulfate or Colistin Sulphate API, Raw Material USP BP EP.jpg

Product Name:  Colistin Sulfate (Colistin Sulphate) API, Raw Material

Synonyms: Colistini sulfas

CAS Number: 1264-72-8

Characteristics: A white or almost white powder. Colistin Sulfate (Colistin Sulphate) is hygroscopic

 

 Colistin Sulfate or Colistin Sulphate API, Raw Material USP BP EP formula-1.gif

 Colistin Sulfate or Colistin Sulphate API, Raw Material USP BP EP formula-2.gif

Colistin Sulfate or Colistin Sulphate API, Raw Material USP BP EP detailed information.jpg

Package: 20Kgs/Fiber DrumCardboard DrumPaper Drum

Description:

Colistin Sulfate raw material, API , also spells Clistin Sulphate, is a mixture of the sulphates of polypeptides produced by certain strains of Bacillus polymyxa var. colistinus or obtained by any other means.

Colistin Sulfate is a polymyxin, cyclic polypeptide related anti-biotic derives from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or can be named Colistin sulfates A, B, and C). Colistin sufate works as detergents on cell membranes. It disrupts the bacterial cell membrane through a detergent-like mechanism. Chemically, Colistin sulphate not as toxic as polymyxin B, while it has similar properties.

 

With the development of less toxic agents, like penicillins and cephalosporins, Colistin Sulfate usage area shrinks a lot, except for the treatment of multidrug-resistant pulmonary infections. Now, however, multidrug-resistant gram-negative bacteria hurts is getting more and more serous. And till now, there is not many new antimicrobial substances, Colistin Sulfate is back to our sight again.

80 percents of the dosed Colistin Sulfate will not be used in body system. They will be found unchanged in the urine with almost no biliary excretion. That is to say only 20% of Colistin sulfate (Colistin Sulphate) is used by our body. There is a good reason to believe that the remaining drug is inactivated in the tissues, but the mechanism is  still unknown to us.

 

Colistin Sulfate is a highly selective anti-biotic. It will prevent and treat infectious enteritis which is caused by gram-ve bacteria especially by Colibacillus, Salmonella in poultry and many other animals. Colistin Sulfate concentrates in the intestinal tract, that is the reason why still have its potency in this tract even with food, enzymes. All these properties make Colistin Sulfate an ideal ingredient for the treatment of a lot of the gastrointestinal tract infections.

 

NOTE: Do not use Colistin Sulfate if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged. 

Content:

Total of Colistins E1, E2, E3, E1-I and E1-7MOA : Min 77.0 %

Colistin E1-I: Maximum 10.0%

Colistin E1-7MOA : Max 10.0%

Colistin E3: Maximum 10.0 %

Standard: EP, USP, CPV.

Package: 20KGS/DRUM, Gross weight: About 24Kg/Drum


As a professional China Colistin Sulfate Salt Powder supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Colistin Sulfate Powder raw material from China for almost 10 years.

 

Mechanism of Action of Colistin Sulfate (Colistin Sulphate)

Colistin Sulfate is a surface active substance which will penetrate into and disrupt the bacterial cell membrane. Colistin Sulfate is polycationic. It has both hydrophobic and lipophilic moieties abilities. Colistin Sulfate interacts with the bacterial cytoplasmic membrane, and changes its permeability. This effect of Colistin Sulfate is bactericidal. It is also widely thought that polymyxins like Colistin Sulfate get into the cell, precipitate cytoplasmic components, mainly like ribosomes. 

Usage: Colistin Sulfate (Colistin Sulphate) is the raw material widely used in vet-Health industry. It will fight against some kind of infections. It also can be made in to Colistin Sulfate premix with different content(Assay)


Symptoms of Colistin Sulfate Overdosage:

Dizziness, Mood or mental changes, uncontrolled eye movements, unsteadiness, etc.

Colistin Sulfate Side Effects:

Feel Light-headed, some dizziness, feel the surrounding moves, skin redness, etc. 

 

COA of Colistin Sulfate (Colistin Sulphate) Raw Material, API

Name   of Product

Colistin Sulfate (Colistin Sulphate)

Testing Item

Standard

Result

Heavy   Metal

≤   0.003%

<   0.003%

Acidity   (pH)

4.0   ~ 6.5

5.9

Specific   optical rotation

Colistin Sulfate

-63°   ~ -73°

-72°

Related   substances

Individual   impurity ≤ 4.0 %

Total   impurities ≤ 23.0 %

1.8%

15.3%

Sulphate  

(as   dried substance)

16.0%   ~ 18.0%

17.1%  

Sulphated   Ash

≤   1.0 %

0.4%

Loss   on drying

≤   3.5%

3.2%

Biological   potency

(as   wet substances)

(as   dried subatance)

 

-------

-------

 

22634   u/mg

23431   u/mg

Assay

Colistin Sulfate

E1+E2+E3+E1-I+E1-7MOA≥   77.0%

E1-I       ≥    10.0 %

E1-7MOA  ≥    10.0 %

E3        ≥    10.0 %

85.2%

0.7%

3.2%

2.8%

 

Top Quality, Pure Colistin Sulfate (Colistin Sulphate) Powder;  Colistin Sulfate (Colistin Sulphate) Raw Material Suppliers in China. Colistin Sulfate (Colistin Sulphate) API Manufacturers. 


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