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Nicarbazin, Nicarbazine Powder API, Raw material CAS 330-95-0

Nicarbazin, Nicarbazine Powder API, Raw material CAS 330-95-0

China Nicarbazin Suppliers, China Nicarbazin Manufacturers CAS 330-95-0 Product Name: Nicarbazin, Nicarbazine Powder API, Raw material CAS 330-95-0 Synonyms: Nicarbazine Chemical name: 1,3-bis(4-nitrophenyl)urea,4,6-dimethyl-1H-pyrimidin-2-one CAS Number: 330-95-0 Characteristics: Odorless Yellow or yellow-green powder. Assay: 99% Min Nicarbazin...

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China Nicarbazin Suppliers, China Nicarbazin Manufacturers CAS 330-95-0

Nicarbazin, Nicarbazine Powder API, Raw material.png


Product Name: Nicarbazin Powder API, Raw material

Synonyms: Nicarbazine

Chemical name: 1,3-bis(4-nitrophenyl)urea,4,6-dimethyl-1H-pyrimidin-2-one

CAS Number: 330-95-0

Characteristics: Odorless Yellow or yellow-green powder. 

Assay: 99% Min Nicarbazin

Formula:  C19H18N6O6; C13H10N4O5•C6H8N2O

Structure Formula: 

Nicarbazin, Nicarbazine Powder API, Raw material formula.png

Package information: 25Kg/Fiber DrumCardboard DrumPaper Drum

KEY Words: Nicarbazin, Nicarbazine Powder API, Raw material

Description: 

Nicarbazin or Nicarbazine is a coccidiostat used in poultry. 

Nicarbazin is a broad spectrum coccidiostat. Its inhibitory action occurs on second-generation schizonts(day 4 in the life cycle). It won’t cause drug resistance. Nicarbazin has been known to prevent and control coccidiosis in many countries. 

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Nicarbazin, Nicarbazine Powder API, Raw material is used for Intestinal and caecal coccidiosis in chickens and other conditions. It is a pharmaceutical ingredient that is used for the treatment of Intestinal and caecal coccidiosis in chickens and other conditions.

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Nicarbazin is a molecular compound of above-mentioned DNC and HDP, an anticoccidial agent showing a wide preventive effect to chicken coccidosis; therefore, it mainly used as an animal drug.

The residue standard value of nicarbazin has been set at 0.2-0.5 mg/kg on DNC base in Food Sanitation Act. This agent was designated to one of feed additives in 1976, and was approved to add to formula feed for growing chicks and broiler chickens in the range of 100-200 g/t to promote the effective use of nutrient components in feeds; however, recently it is approved to add only to formula feeds for broiler chickens in the prior stage at 100 g/t.

This agent is brownish yellow to greenish yellow powder without odor or with slight special odor.

It is slightly soluble in N,N-dimethylformamide, and very slightly soluble in water, ethanol, ether and Chloroform

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Other Names:

Nicarbazin; CL22,791 Urea, N,N'-bis(4-nitrophenyl)-compound with

4,6-dimethyl-2(1H)-pyrimidinone, CycarbN-N'-bis(4-nitrophenyl)urea, compound with 4,6-dimethyl-2(1H)-pyrimidinone (1:1); 4,4'-dinitrocarbanilide ; nicarb; nicoxin;nicarzin

Nitrophenylurea with pyrimidin, Carbanilide

 

Nicarbazin, Nicarbazine Powder API, Raw material is a synthetic broad spectrum chemical anticoccidial for prevention and control of coccidiosis in broilers. It is designed for continuous prophylactic use in broiler chickens. Nicarbazin, Nicarbazine Powder API, Raw material have protective action. Nicarbazin interferes with mitochondrial metabolism and inhibits oocyst production. It is a broad spectrum anti-coccidial effective for the prevention of coccidiosis caused by E.tenella, E.acervulina, E.maxima, E.necartrix and E.brunetti.

Nicarbazin, Nicarbazine Powder API, Raw material can also be combined with ionophoressuch as Maduramicin Ammonium to offer a better coccidia control in shuttle programs. It has also been widely approved for prevention and control of coccidiosis in broilers in many countries.

 

Specification

Pure form: Nicarbazin, Nicarbazine Powder API, Raw material Min. 99%;  25% Premix

Under conditions of mild exposure to coccidiosis: use 0.01-0.0125% nicarbazin  in complete feed.

Under conditions of moderate exposure: use 0.0125-0.015% nicarbazin.

Under conditions of severe exposure: use 0.02% nicarbazin  (up to and including 12 weeks of age).

Replacement Chickens: Use 0.008% nicarbazin from eight (8) weeks of age until the birds are moved to the laying house.

Mixing Directions: It is recommended that a premix be made before final incorporation into the complete feed.

Mix 25 kg of Niarbazin with 225 kg of a feed ingredient to obtain a 2.5% premix. Use this 2.5% premix as follows

Withdrawal Time:

1. Do not feed Nicarbazin Powder API, Raw material to laying or breeding hens in production.

2. Nicarbazin Treated poultry should not be slaughtered for use in food for at least four days after the last treatment with Nicarbazin.

Caution:

1. Do not use Nicarbazin, Nicarbazine Powder API, Raw material for the treatment of outbreaks of coccidiosis.

2. If unexpected deaths occur, obtain a laboratory diagnosis and follow a veterinarian's or poultry pathologist's instructions.

Storage: Kept in a tight-closed container, protected from light and stored  in a dry place.

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As a professional China Nicarbazin, Nicarbazine Raw Material supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Nicarbazin, Nicarbazine API from China in China for almost 10 years.


Advantages of Nicarbazin:

1. Nicarbazin have a good effect on prevention and treatment of coccidiosis caused by Eimeria coccidium.

2. Nicanbazin mainly action on second-generation schizozoite and schizonts(Peak In 4 days after infection)

3. Nicarbazin does not affect the immune competence of poultry.

4. Resistance to Nicarbazin develops very very slowly.

Usage 

Mechanism of Action of Nicarbazin: 

Nicarbazin interferes with the formation of the vitelline membrane. 

Nicarbazin can attack the ATP. By this way it interrupts the cell supplying energy, and lead to the Na-K pump on the cell walls stop working, then a large number of sodium ions into the cells with the water. Finally, the ions in the coccidia cells break balance or broken the cell , and lead to the coccidia death.

NOTE: Layer is forbidden to use Nicarbazin.

Precautions:

- Forbid using in the laying chicken and breeder chicken.

- Be more careful when using in high temperature season.

- Forbid feeding directly. Eating is prohibited in the other livestock and poultry and human body. 

Application:

Pharmacology:

Kill the second-eneration schizonts and trophozoites, reducing intestinal cell damage of the chicken.

Indications of Nicarbazin:

Nicarbazin is used as Anti-protozoan substance. 

It has preventive effect on Chicken Coccidiosis. 

Main indexes of Nicarbazin: Please contact us to get the Certificate of Analysis. 

Top Quality, Pure Nicarbazin Powder;  Nicarbazin Raw Material Suppliers in China. Nicarbazin API Manufacturers. 

 

Name   of Product

Nicarbazin

Testing Item

Standard

Result

Appearance  

Yellow   or light yellow powder

Complies

Identification

Should comply.

Complies

Ammonium Salt

≤ 1.0%

0.08%

Acidity or alkalinity

pH   5.0-7.0

6.1

2-hydroxy-4,6-dimethylpyrimidine

≤ 0.35%

0.11%

Loss   on drying

≤   1.0%

0.12%

Residual on Ignition

≤ 0.5%

< 0.5%

Heavy   Metal

≤ 20ppm

<   20ppm

Purity   (Assay)

99.0%

99.27%





 Property:

Name: Nicarbazin

EINECS: 206-359-1

Nicarbazin CAS No.: 330-95-0

Nicarbazin Solubility: Insoluble in water, ethanol, chloroform and ether, slightly soluble in dimethylformamide

Formula: C13H10N4O5.C6H8N2O

Boiling Point: 414.8 °C at 760 mmHg

Nicarbazin Molecular Weight: 426.38

Flash Point: 204.7 °C

Absorption maximum: uv max (concd H2SO4): 298 nm (A1%1cm 670)

Therap-Cat-Vet: Coccidiostat.

 

Top Quality, China Pure Nicarbazin Powder/Substance factory in China; China Nicarbazin Raw Material Suppliers in China. Chian Nicarbazin API Manufacturers in China. 


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Nicarbazin, Nicarbazine Powder API, Raw Material CAS 330-95-0

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