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Oxacillin Sodium Salt Sterile for injection grade CAS 1173-88-2

Oxacillin Sodium Salt Sterile for injection grade CAS 1173-88-2

Oxacillin Sodium Salt Sterile for injection grade CAS 1173-88-2 Product Name: Oxacillin Sodium Salt Sterile Synonyms: Oxacillinum natricum, Oxacilline Sodium CAS Number: 1173-88-2 Characteristics: A White powder or crystalline powder Assay and Potency: 815µg/Mg ~ 950µg/Mg Oxacillin (C19H19N3O5S) Formula:...

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Oxacillin Sodium Salt Sterile for injection grade CAS 1173-88-2                                              Oxacillin Sodium Salt Sterile for injection grade picture.jpg

Product Name:  Oxacillin Sodium Salt Sterile

Synonyms:  Oxacillinum natricum, Oxacilline Sodium

CAS Number:  1173-88-2

Characteristics:  A White powder or crystalline powder

Assay and Potency:  815µg/Mg ~ 950µg/Mg Oxacillin (C19H19N3O5S)

Formula:  C19H18N3NaO5S·H2O      441.43

Oxacillin Sodium Salt Sterile for injection grade formula.gif

Package:  5Kg/Tin, 2Tins/Ctn

Oxacillin Sodium USP BP EP.png


Oxacillin Sodium USP .png

Description:

Oxacillin Sodium USP is a semis-ynthetic antibiotic substance derived from 6-amino-penicillanic acid. It is the sodium salt of Oxacillin. The chemical name of oxacillin sodium is 4-Thia-1­ azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-6-[[(5-methyl-3-phenyl-4­ isoxazolyl)carbonyl]-amino]-7-oxo-, monosodium salt, monohydrate, [2S-(2α,5α,6ß)]-. It is resistant to inactivation by the enzyme penicillinase (beta-lactamase).

Oxacillin Sodium is widely applied for the treatment of resistant staphylococci infections, caused by gram-positive, organisms.

The bactericidal activity of Oxacillin sodium is because of its inhibition ability of cell wall synthesis. Oxacillin sodiumis also binds to penicillin binding proteins.

Oxacillin sodium is stable against hydrolysis by a lot of beta-lactamases, such as penicillinases, and cephalosporinases and some extended spectrum beta-lactamases.

Intravenous administration of Oxacillin Sodium will reach its peak serum levels in about 5 minutes after the injection. By slow I.V. administration of 500 mg,  Oxacillin Sodium will give a peak serum level of 43 mcg/mL in about 5 minutes.


Usage: Oxacillin Sodium Sterile usually will add a little pharmaceutical excipients, the sodium dihydrogen phosphate.  It will Inhibits mucopeptide synthesis in bacterial cell wall. Please only use Oxacillin Sodium when it should work.

Oxacillin sodium should be indicated in the treatment of infections caused by penicillinase producing staphylococci which have demonstrated susceptibility to the drug.

 

Mechanism of Action:

Oxacillin Sodium will interfere with the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Oxacillin interferes with an autolysin inhibitor.

 

Oxacillin Sodium Side Effects:

Adverse effects include Swollen, black, or "hairy" tongue, thrush

COA—Oxacillin Sodium Salt Sterile

Appearance  

Oxacillin Sodium

A   White powder or crystalline powder

Complies

Identification  A

A: The chromatogram of the Assay preparation obtained as   directed in the Assay exhibits a major peak for oxacillin, the retention time   of which corresponds to that exhibited in the chromatogram of the Standard   preparation obtained as directed in the Assay.

Complies

Identification  B

Oxacillin Sodium

B: It responds to the tests for Sodium.

Complies

Crystallinity

Should comply

Complies

pH

Oxacillin Sodium

4.5   ~ 7.5

6.68

Water (Moisture)

3.5% ~ 5.0%

4.83%

Clarity of solution

≤ 0.75#

≤ 0.5#(-)

Color of solution

Colorless

Colorless

Particulate Matter

Meets   the requirements

Complies

Visible   Foreign Matter

Absent

Absent

Bacterial Endotoxin

Meets   the requirements

Complies

Sterility

Sterile

Sterile

Residual   solvent


Ethanol ≤ 0.5%

0.035%

Ethyl Acetate ≤ 0.5%

Not detect

1-Butanol ≤ 0.5%

0.021%

Butyl Acetate ≤ 0.5%

0.15%

Assay

815ug/mg   ~ 950ug/mg Oxacillin Sodium

947.6ug/mg

 

Top Quality, Pure Oxacillin Sodium Powder;  Oxacillin Sodium Raw Material Suppliers in China. Oxacillin Sodium API Manufacturers. 


Related similar product you may interested:    

Oxacillin Sodium Salt Sterile

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