Ceftriaxone Sodium Salt Sterile for injection grade CAS 74578-69-1
Ceftriaxone Sodium Salt Sterile CAS 74578-69-1 Product Name: Ceftriaxone Sodium Salt Sterile Synonyms: Ceftriaxonum natricum CAS Number: 74578-69-1 Characteristics: White or yellowish-white crystalline powder Assay and Potency: (1)USP & BP Standard: Minimum 795µg/mg of ceftriaxone (C 18 H 18...
Ceftriaxone Sodium Salt Sterile for injection Grade CAS 74578-69-1
Product Name: Ceftriaxone Sodium Salt Sterile for injection grade
Synonyms: Ceftriaxonum natricum
CAS Number: 74578-69-1
Characteristics: White or yellowish-white crystalline powder
Assay and Potency:
(1)USP & BP Standard: Minimum 795µg/mg of ceftriaxone (C18H18N8O7S3)
(2) EP Standard: 96%~102%
Package: 6Kgs/Sterile Tin, 2 Tins/Ctn; 10Kg/Tin; 5Kg/Tin, 2Tins/Ctn
Ceftriaxone Sodium is the sodium salt of Ceftriaxone, which belongs a group of antibiotics known named cephalosporins. Ceftriaxone Sodium is usually prescribed by our doctor to prevent or treat certain bacteria-caused infections.
Ceftriaxone Sodium is widely applied for infections like respiratory tract infections, urinary tract infections, and some other infections. It is also working when fight against gonorrhea, septicemia, especially popularly used in coronary bypass operations. One of the advantages of Ceftriaxone Sodium is that it has a relative longer half-life. The dosage of Ceftriaxone Sodium should be decreased if use it to the patients with renal impairment. Ceftriaxone Sodium one of the few cephalosporins which will be eliminated primarily by the liver.
Ceftriaxone Sodium is a 3rd generation cephalosporin with a broad-spectrum activity against Gram-positive bacteria and expanded Gram-negative coverage.
By injection, Ceftriaxone Sodium can only be given into muscle or vein.
Usage: To make Ceftriaxone Sodium Salt Sterile injections
Ceftriaxone Sodium is often used (in combination, but not direct, with macrolide and/or aminoglycoside antibiotics) for the treatment of community-acquired or mild to moderate health care-associated pneumonia. Ceftriaxone Sodium is also an alternative for treating bacterial meningitis. In pediatrics, Ceftriaxone Sodium is usually used in febrile infants between four to eight weeks old
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-Ceftriaxone Sodium is not right choice the infant has hyperbilirubinemia. It competes with bilirubin for binding sites on albumin.
-Ceftriaxone Sodium should be used with caution in combined renal and hepatic failure.
ADVERSE REACTIONS or Side effects of Ceftriaxone Sodium:
Diarrhea, pseudomembranous colitis, vomiting, Haemolysis and Skin rash are reported side effects of Ceftriaxone Sodium. There can be also conditions like Eosinophilia, thrombocytosis, Hypoprothrombinaemia, leukopenia, increase in bleeding times. Very rare, Biliary sludging
Mechanism of Action:
Ceftriaxone sodium will interfere with bacteria cell walls synthesis. Eventually will lead to the death of bacteria.
Ceftriaxone sodium can interact with a number of medicines, which include, but are not limited to Warfarin, Sulfinpyrazone, Probenecid, etc.
RS of Ceftriaxone Sodium:
Appearance: Ceftriaxone Sodium
White or yellowish-white crystalline powder
the particles show birefringence (interference colors) and extinction positions when the microscope stage is revolved.
Identification: Ceftriaxone Sodium
Infrared-spectrometry: The spectrum of the substance to be examined and of a qualified reference standard are comparable to the position of the absorption bands
HPLC: The retention time of major peak in the chromatogram of test solution correspond to this of standard solution
Test for solution: It responds to the reaction of sodium
Visible foreign matter
6.0 ~ 8.0
Deacetylcefotaxime lactone: ≤ 0.5%;
Total impurities: ≤ 2.5%
8.0% ~ 11.0%
Triethylamine ≤ 0.02%
N,N-dimethylaniline ≤ 0.002%
2-ethylhexanoic acid ≤ 0.8%
Isoproranol ≤ 0.5%
Methanol ≤ 0.3%
Acetone ≤ 0.5%
Methylene chloride ≤ 0.06%
Ethyl acetate ≤ 0.5%
Ethanol ≤ 0.5%
≤ 0.20 USP Endotoxin Unit/mg of Ceftriaxone
Should be sterile
≥ 795ug/mg of Ceftriaxone (Dried basis)
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