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Fenofibrate Powder API, Raw Material CAS 49562-28-9

Fenofibrate Powder API, Raw Material CAS 49562-28-9

China Fenofibrate Suppliers, China Fenofibrate Manufacturers CAS 49562-28-9 Product Name: Fenofibrate Powder API, Raw Material CAS 49562-28-9 Synonyms: Fenofibratum CAS Number: 49562-28-9 Chemical Name: propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate Characteristics: A white or almost white, crystalline powder Assay:...

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China Fenofibrate Suppliers, China Fenofibrate Manufacturers CAS 49562-28-9

Fenofibrate Powder API, Raw Material.jpg

Product Name:  Fenofibrate Powder API, Raw Material

Synonyms:  Fenofibratum

CAS Number: 49562-28-9

Chemical Name: propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate

2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester, Fenofibratum, Fenofibrato

Characteristics: A white or almost white, crystalline powder

Assay:  98.0% ~ 101.0% Fenofibrate Powder API, Raw Material

Formula: C20H21ClO4 

Structure Formula:

Fenofibrate Powder API, Raw Material formula.gif

KEYWORD: Fenofibrate Powder API, Raw Material

Standard: Fenofibrate BP, EP Standard

Package: 25Kgs/Drum

  As the most famous China Fenofibrate BP, EP Powder supplier in China, Fengchen Group’s Fenofibrate BP, EP Powder is well packed with the newest and the safest package. 

Description:  

Fenofibrate is an antilipemic substance. It will reduce both cholesterol and triglycerides in the blood.

Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity. Overall, Fenofibrate reduces total triglycerides, total cholesterol, and triglyceride rich lipoprotein.

Actually, Fenofibrate Powder API, Raw Material is a prodrug of fenofibric acid. It is an anti-lipemic substance which will help to reduces both cholesterol and triglycerides (fatty acids) levels in our blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries). Fenofibrate is used to treat high cholesterol and high triglyceride levels.

 

Fenofibrate Powder API, Raw Material belongs to the class of organic compounds named “benzophenones”. These are organic compounds containing a ketone attached to two phenyl groups. Fenofibrate Powder API, Raw Material is most commonly made into formulations like Fenofibrate tablets, Fenofibrate Capsules. Fenofibrate is a member of the fibric acid derivatives drug class and is commonly used for Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa - Elevated LDL, Hyperlipoproteinemia Type IIb - Elevated LDL VLDL, and others.

 Generally:

Fenofibrate is an anti-hyperlipidaemic drug, belongs to fibrates. It works primarily by decreasing serum triglycerides; Fenofibrate has several effects on LDL-cholesterol. Fenofibrate is used in hyperlipdaemias of type II a, II b, III, IV and V for those who have not respond adequately to the dietand other appropriate measures. Fenofibrate Powder API, Raw Material will as well reduce the risk of coronary heart disease events for the patients suffering HDL-cholesterol or with raised triglycerides.

 

As a professional China Fenofibrate Powder API, Raw Material supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Fenofibrate Powder API, Raw Material from China in China for almost 10 years.

Mechanism:

The mechanism of action of Fenofibrate is as a Peroxisome Proliferator-activated Receptor alpha Agonist.

 Fenofibrate exerts its therapeutic effects through activation of peroxisome proliferator activated receptor a (PPARa). It will increase lipolysis and eliminate some triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III. The resulting fall in triglycerides produces an alteration in the size and composition of LDL from small, dense particles, to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly.

Usage:

Fenofibrate is the raw material to make some antilipemic medicines.

 Categories: 12 Cardiovascular drugs

12.6 Lipid-regulating drugs /Anti-atheromas

 Fenofibrate Indications:

For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia 

Fenofibrate Contraindications:

Fenofibrate is contraindicated in conditions like Gall stones, Liver diseases, Renal impairment, Hypersensitivity, Pregnancy.

 

Fenofibrate Side Effects:

Although the adverse reactions are rare, Fenofibrate may still lead to upset stomach, constipation, headache, dizziness or sleep problems.

If the above side effects caused by Fenofibrate persist or even worsen, please notify your doctor immediately.

Very unlikely but report promptly if there is the following symptoms after taken Fenofibrate: decreased sexual drive, yellowing eyes or skin, stomach pain.

If by any chance you are allergic to Fenofibrate, look for quick medical attention. Symptoms of an allergic reaction of Fenofibrate can be: rash, itching, swelling, dizziness, trouble breathing.

 

Overdose:

If overdosed with Fenofibrate, turn to professionals immediately.

Missdose:

If you miss a dose, use Fenofibrate as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up. It is very important.

 

Routine of Elimination:

Fenofibrate is primarily conjugated with glucuronic acid and then excreted in urine. Following oral administration as instructions, about sixty percents of a single dose of fenofibrate will show in urine, mainly as fenofibric acid and its glucuronate conjugate and twenty five percents will be excreted in the feces.

 

Top Quality, China Pure Fenofibrate Powder/Substance factory in China; China Fenofibrate Raw Material Supplier in China. China Fenofibrate API Manufacturer in China.


COA of Fenofibrate—Please contact us to get it. 

ITEMS

SPECIFICATIONS

RESULTS

DESCRIPTION

Fenofibrate

WHITE OR OFF-WHITE CRYSTALLINE POWDER

CONFORMS

SOLUBILITY

Fenofibrate

FREELY SOLUBLE IN METHYLENE CHLORIDE AND IN ALCOHOL; PRACTICALLY   INSOLUBLE IN WATER

CONFORMS

IDENTIFICATION

A.      IR-SPECTRUM

B.      HPLC

MATCHES WITH WORKING STANDARD

CONFORMS

SPECIFIC ROTATION

-56° ~  -60°

-58°

WATER

Not more than 0.3%

0.14%

RESIDUE ON IGNITION

Not more than 0.1%

0.01%

HEAVY METALS

Not more than 10Mg/g

<10ΜG/G

RELATIVE MATERIAL

MAJOR Not more than 0.5%

TOTAL  Not more than 1.0%

0.39%

0.77%

PARTICLE SIZE

100%  Not more than 20   MICRONS

90% Not more than 10 MICRONS

CONFORMS

RESIDUAL SOLVENTS

MEETS THE REQUIREMENTS

CONFORMS

ASSAY

(HPLC,BASIS ON DRYING)

98.5% ~ 101.0%  Fenofibrate

99.05%

CONCLUSION

CONFORMS TO USP39

  Shipment & Delivery: Fengchen Group is one of the best known Fenofibrate BP, EP Powder Manufacturer in China, our shipment is professional and relatively fast.  

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Fenofibrate Powder API, Raw Material CAS 49562-28-9




If you are looking for the Fenofibrate Powder API, Raw Material CAS 49562-28-9, welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.
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