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Butylparaben CAS 94-26-8 and Sodium Butylparaben CAS 36457-20-2 Powder Raw Material, API

Butylparaben CAS 94-26-8 and Sodium Butylparaben CAS 36457-20-2 Powder Raw Material, API

Butylparaben CAS 94-26-8 and Sodium Butylparaben CAS 36457-20-2 Powder Raw Material, API Keywords: Butylparaben, Sodium Butylparaben Description and usage: Butylparaben, also named Butyl p-hydroxybenzoate, Butyl paraben, Butyl 4-hydroxybenzoate. It is an organic compound. It is soluble in organic solvents. Butylparaben...

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Product Details

Butylparaben CAS 94-26-8 and Sodium Butylparaben CAS 36457-20-2

Butylparaben and Sodium Butylparaben.png

Product Name:

Butylparaben

Sodium Butylparaben

Synonyms:

Butyl p-hydroxybenzoate, Butyl paraben, Butyl 4-hydroxybenzoate

Sodium Butyl p-hydroxybenzoate
     Sodium Butyl 4-hydroxybenzoate
     Butylparaben Sodium Salt

Characteristics:

White powder

White crystalline powder

CAS Number:

94-26-8

36457-20-2

Formula:

C11H14O3

C11H13NaO3; C11H13O3•Na

Structure:

Butylparaben and Sodium Butylparaben formula.png

Butylparaben and Sodium Butylparaben structure.png

Package:

25Kgs/Drum

25Kgs/Fiber DrumCardboard DrumPaper Drum

Keywords: Butylparaben, Sodium Butylparaben Powder Raw Material, API

Description and usage:
Butylparaben, also named Butyl p-hydroxybenzoate, Butyl paraben, Butyl 4-hydroxybenzoate. It is an organic compound. It is soluble in organic solvents. Butylparaben is believed to be a highly successful antimicrobial preservative in cosmetics and medication suspensions and as flavor additive in food.
Butylparaben is a Standardized Chemical Allergen. The physiologic effect of butylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity.
Butylparaben is also a preservative and flavouring agent. It has anti-microbial function.
Butylparaben belongs to the family of Hydroxybenzoic Acid Derivatives. These are compounds containing an hydroxybenzoic acid (or a derivative), which is a benzene ring bearing a carboxylic acid.
PHYSICAL DESCRIPTION: Odorless white crystals or crystalline powder. Tasteless, but numbs the tongue. Aqueous solutions slightly acidic to litmus

Uses:
Butylparaben, also named Butyl p-hydroxybenzoate, Butyl paraben, Butyl 4-hydroxybenzoate is widely used in Pharmaceutical Industry and Cosmetic production. As additive.

As a professional China Butylparaben, Sodium Butylparaben Powder Raw Material, API supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Butylparaben, Sodium Butylparaben Powder Raw Material, API from China in China for almost 10 years.

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Safety researches and studies:

1.Skin irritation and sensitization

Five percents Butylparaben, Sodium Butylparaben Powder Raw Material, API will not cause any irritation or sensitization when applied to the skin. Butylparaben, Sodium Butylparaben Powder Raw Material, API is a weak sensitizer with positive reaction rates in patch tests of usually around one to three percents.

 

2. Genotoxicity

When 1% Butylparaben, Sodium Butylparaben Powder Raw Material, API is using combined with potassium nitrate or sodium nitrite and irradiated for 5 days, butyl-3-nitro-4-hydroxybenzoate is formed. This reaction product has been found to be mutagenic in an assay used to detect DNA-damaging agents, though butylparaben itself was nonmutagenic in the same assay.

Another experiment suggests that Butylparaben, Sodium Butylparaben Powder Raw Material, API induced a slight (1-3%) increase in polyploid cell production in Chinese hamster cells, but will not increase chromosomal aberrations. However, this contradicts the findings of a most recent study, which demonstrated that Butylparaben, Sodium Butylparaben Powder Raw Material, API may lead to detectable DNA damage and induced chromosomal aberrations together with sister-chromatid exchanges in Chinese hamster ovary cells.

 

3. Developmental toxicity:

Pregnant rats injected subcutaneously with 100 or 200 mg/kg of Butylparaben, Sodium Butylparaben Powder Raw Material, API from gestation day 6 to postnatal day 20 had a lower proportion of pups born alive (both doses) and a lower proportion of pups surviving to weaning (200 mg/kg dose). Moreover, the body weights of female offspring were significantly decreased, whereas for male offspring the sperm counts and sperm motile activity in the epididymis were significantly decreased. Other researches also prove that exposure to Butylparaben, Sodium Butylparaben Powder Raw Material, API and during lactation has adverse effects on the reproductive system in male offspring, including reduced anogenital distance, delayed preputial separation, reduced reproductive organ weights, lower sperm production and sperm counts, and changes in the levels of testosterone, estradiol, FH and LSH. However, an other recent research in which pregnant rats were fed Butylparaben, Sodium Butylparaben Powder Raw Material, API by oral gavage at levels up to 1000 mg/kg/day and caesarean sections were performed on gestation day 20, did not find any differences from control in embryo/fetal viability, fetal weight, malformations or variations.

 

The impact of Butylparaben, Sodium Butylparaben Powder Raw Material, API on the brains of pups has also been examined. In some studies, female rats were orally and subcutaneously administered Butylparaben, Sodium Butylparaben Powder Raw Material, API from early pregnancy till weaning, and its effects on the behaviour, brain neurotransmitters and brain derived neurotrophic factor (BDNF) were compared with those of a valproic acid (VA) autistic-rat model. Compared to the controls, the male offspring exposed to Butylparaben, Sodium Butylparaben Powder Raw Material, API showed similar social and learning and memory behavioral deficits as in the VA rat model. Some similar alterations in the monoamine content, amino acids and BDNF factor were also observed between the 2 groups, suggesting that prenatal exposure to Butylparaben, Sodium Butylparaben Powder Raw Material, API induced autism-like symptoms in the offspring.

 

4. Effects on reproduction

Butylparaben, Sodium Butylparaben Powder Raw Material, API  with the concentration 1 mg/ml is capable of completely inactivating human sperm. When high up to one percent dietary Butylparaben, Sodium Butylparaben Powder Raw Material, API was administered to male rats, the weights of the epididymides, the cauda epididymal sperm reserve, sperm production and serum testosterone levels will be lowered. A similar experiment on male mice suggest that dietary Butylparaben, Sodium Butylparaben Powder Raw Material, API will decrease spermatid counts and serum testosterone concentrations, but did not significantly affect the numbers of spermatogonia or spermatocytes. Also, unlike the study on rats, the weights of the epididymides were significantly higher in the one percent group when compared with controls.

 

Studies on prepubertal rats indicate that Butylparaben, Sodium Butylparaben Powder Raw Material, API can disrupt the Sertoli cell vimentin filaments, which may cause the precocious release of spermatogenic cells from underlying Sertoli cells. The released cells may then undergo apoptosis owing to the loss of support provided by the Sertoli cells. Another possible explanation for the reduced sperm counts induced by Butylparaben, Sodium Butylparaben Powder Raw Material, API may be related to its causation of DNA hypermethylation in epididymal sperm, as evidenced by a study on rats. It has also been hypothesized that the effect of Butylparaben, Sodium Butylparaben Powder Raw Material, API on male fertility has to do with the interaction between Butylparaben, Sodium Butylparaben Powder Raw Material, API and mitochondrial function in the testis.

 

Butylparaben, Sodium Butylparaben Powder Raw Material, API led to myometrial hypertrophy when fed to peripubertal female rats, though it did not influence the number of corpora lutea in mature female rats.

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Property:

Name: Butylparaben, Butyl Paraben

EINECS: 202-318-7

CAS No.: 94-26-8

Butylparaben, Butyl Paraben Density: 1.108 g/cm3

Butylparaben, Butyl Paraben Solubility: water: <0.1 g/100 mL at 17 °C

Butylparaben, Butyl Paraben Melting Point: 67-70 °C(lit.)

Formula: C11H14O3

Boiling Point: 309.2 °C at 760 mmHg

Butylparaben, Butyl Paraben Molecular Weight: 194.25

Flash Point: 129.2 °C

Safety: 22-24/25

Risk Codes: 36/37/38

 

Other names:

Benzoicacid, p-hydroxy-, butyl ester (6CI,8CI);4-(Butoxycarbonyl)phenol;4-Hydroxybenzoic acid butyl ester;Aseptoform Butyl;Butoben;Butyl4-hydroxybenzoate;Butyl Butex;Butyl Tegosept;Butyl chemosept;Butylp-hydroxybenzoate;Butyl parabens;Butyl parasept;Mekkings B;NSC 13164;NSC 8475;Nipabutyl;Preserval B;SPF;Solbrol B;Tegosept Butyl;n-Butyl 4-hydroxybenzoate;n-Butylparaben;p-Hydroxybenzoic acid butyl ester;Butyl paraben;

 

Top Quality, China Pure Butyl Paraben, Sodium Butylparaben Powder/Substance factory in China; China Butyl Paraben, Sodium Butylparaben Raw Material Suppliers in China. China Butyl Paraben, Sodium Butylparaben API Manufacturers in China. 


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Butylparaben CAS 94-26-8 Powder Raw Material, API

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