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Amantadine Hydrochloride or Amantadine Hcl CAS 665-66-7 Powder Raw Material API

Amantadine Hydrochloride or Amantadine Hcl CAS 665-66-7 Powder Raw Material API

Amantadine Hydrochloride or Amantadine Hcl CAS 665-66-7 Product Name: Amantadine Hydrochloride or Amantadine Hcl CAS Number: 665-66-7 Characteristics: White crystalline powder Assay: 99.0% Min Amantadine Hydrochloride Formula: C10H18ClN, C10H 17N·HCl Structure Formula: Standard: Package...

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Amantadine Hydrochloride or Amantadine Hcl CAS 665-66-7 

Amantadine Hydrochloride or Amantadine Hcl Powder Raw Material API.png


Product Name: Amantadine Hydrochloride or Amantadine Hcl

CAS Number: 665-66-7

Characteristics: White crystalline powder

Assay: 99.0% Min Amantadine Hydrochloride

Formula:  C10H18ClN, C10H 17N·HCl

Structure Formula: 

Amantadine Hydrochloride or Amantadine Hcl Powder Raw Material API formula.png

Standard:
Package information: 25Kg/Fiber DrumCardboard DrumPaper Drum

Keywords: Amantadine Hydrochloride, Amantadine Hcl Powder Raw Material API


Description and usage:
Amantadine Hcl is used to treat or prevent infections of the respiratory tract caused by a certain virus. 

Amantadine hydrochloride Powder Raw Material API BP, EP, USP is a stable white or nearly white crystalline powder. Amantadine Hcl is freely soluble in water and soluble in alcohol and in chloroform.

Pharmaceutically, Amantadine hydrochloride Powder Raw Material API BP, EP, USP has pharmacological actions as both an anti-Parkinson and an antiviral drug.


Function and Usage of Amantadine Hydrochloride:
Amantadine Hcl  is mainly used to make intermediate of antivirus medicines. It treats A2 type flu virus. Amantadine Hydrochloride has antipyretic effect in the clinical pharmacology. Moreover, it will amend fremitus and anaesthesia of Parkinson's disease symptom.
What’s more, Amantadine Hydrochloride is Anti-viral. It is also used in treatment of drug-induced extrapyramidal reactions. 

The Antiviral action of Amantadine hydrochloride is unclear;

Amantadine Hcl may prevent penetration of influenza A virus into host cell.

The Anti-parkinsonian action of Amantadine hydrochloride is also unknown;

It may ease parkinsonian symptoms by increasing dopamine release, preventing dopamine reuptake into presynaptic neurons, stimulating dopamine receptors, or enhancing dopamine sensitivity.


As a professional China Amantadine Hcl, Amantadine Hydrochloride Raw Material supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Amantadine Hcl, Amantadine Hydrochloride API from China in China for almost 10 years.


Available in USP and EU Ph. grades.
Good news:
Amantadine hydrochloride has pharmacological actions as both an anti-Parkinson and an antiviral drug.

Precautions:
Amantadine Hydrochloride should not be suddenly stopped abruptly in patients with Parkinson's disease, for example a sudden marked clinical deterioration. The dose of Amantadine Hcl should be reduced if atropine-like effects appear when these drugs are used concurrently.
Abrupt discontinuation of Amantadine Hydrochloride may also precipitate delirium, depression and slurred speech.
Mechanism of Action – Antiviral 
Amantadine Hcl exerts its antiviral activity mechanism is not clearly understood. It appears to mainly prevent the release of infectious viral nucleic acid into the host cell by interfering with the function of the transmembrane domain of the viral M2 protein. In certain cases, Amantadine Hydrochloride is also known to prevent virus assembly during virus replication. It does not appear to interfere with the immunogenicity of inactivated influenza A virus vaccine.
Mechanism of Action: Parkinson's Disease
Data from earlier animal studies suggest that Amantadine Hcl may have direct and indirect effects on dopamine neurons. More recent studies have demonstrated that Amantadine Hydrochloride is a weak, non-competitive NMDA receptor antagonist (Ki = 10µM). Although Amantadine Hcl has not been shown to possess direct anti-cholinergic activity in animal studies, clinically, Amantadine Hydrochloride exhibits anti-cholinergic-like side effects such as dry mouth, urinary retention, and constipation.


Side Effects of Amantadine hydrochloride Powder Raw Material API BP, EP, USP:

There can be adverse reactions like hives; difficulty breathing; swelling of your face, lips, tongue, or throat if you take Amantadine hydrochloride Powder Raw Material API BP, EP, USP for long time.

 

Serious side effects:

feeling depressed, agitated, or aggressive; feeling short of breath, even with mild exertion;

swelling, rapid weight gain; behavior changes, hallucinations, thoughts of hurting yourself;

high fever, stiff muscles, confusion, sweating, fast or uneven; urinating less than usual or not at all;


Indexes of Amantadine Hydrochloride or Amantadine Hcl:

Appearance
 Amantadine Hydrochloride

White crystalline powder

Assay
Amantadine Hcl

100.05%

Clarity and color

Transparent and almost colorless

Acidity (ph)

3.6

Heavy metals

<0.001%

Residual solvent (acetone)

0.04%

Top Quality, Pure Amantadine Hydrochloride, Amantadine Hcl Powder; Amantadine Hydrochloride, Amantadine Hcl Raw Material Suppliers in China. Amantadine Hydrochloride, Amantadine Hcl API Manufacturers.


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Amantadine Hydrochloride Or Amantadine Hcl CAS 665-66-7 Powder Raw Material API

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Skype: frankrenful2002
E-Mail: frank_feng@fengchengroup.com
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Add: Room 1101, 5th Building, No.168 Shenzhen Road, Qingdao, China
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