Home > Product > Pharmaceutical API > AntiViral
Product Categories
Contact Us

Skype: frankrenful2002
E-Mail: frank_feng@fengchengroup.com
Tel: +86-186-7846 1007
WECHAT: +86-18678461007
WHATSAPP: +86-18678461007
Add: Room 1101, 5th Building, No.168 Shenzhen Road, Qingdao, China

Lamivudine or Lamivudin BP EP USP CAS 134678-17-4

Lamivudine or Lamivudin BP EP USP CAS 134678-17-4

Lamivudine or Lamivudin BP EP USP CAS 134678-17-4 Product Name: Lamivudine Synonyms: Lamivudin CAS Number: 134678-17-4 Characteristics: White or off white crystalline powder Assay: 98%~102%, anhydrous and solvent-free basis Formula: C8H11N3O3S Package: 1Kg/Drum Usage: Lamivudine (Lamivudin) is...

Send Inquiry

Product Details

Lamivudine or Lamivudin BP EP USP CAS 134678-17-4                                              Lamivudine or Lamivudin BP EP USP raw material API picture.jpg

Product Name:  Lamivudine

Synonyms: Lamivudin

CAS Number: 134678-17-4

Characteristics: White or off white crystalline powder

Assay:  98%~102%, anhydrous and solvent-free basis Lamivudine

Formula:     C8H11N3O3S

Lamivudine or Lamivudin BP EP USP formula.gif

Package: 1Kg/Drum

Chemical Name: (-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine

Lamivudine Description:

Lamivudine is a reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is an antiviral active ingredient which will prevent and treat human immunodeficiency virus. Lamivudine is also effective when fighting against hepatitis B virus from multiplying in our body. Lamivudine will be very rapidly absorbed after oral administration.

 

Lamivudine Mechanism of Action:

Lamivudine is phosphorylated to active metabolites which compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain stopper for DNA synthesis. A lack of a 3OH group in the incorporated nucleoside analogue will prevent the formation of the 5 to 3 phosphodiester linkage which is very essential for DNA chain elongation. By this way, the viral DNA growth will be totally stopped.

In other words, Lamivudine is a synthetic nucleoside analogue. It is phosphorylated intracellularly to its active 5triphosphate metabolite. This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, causing DNA chain termination. And the virus will be killed.

 As a professional China Lamivudine supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Lamivudine from China for almost 10 years.

 

NOTES:

Lactic acidosis will be the side effect of Lamivudine, although the chances is small. If there is mild symptoms like, muscle pain or weakness, please to turn to your doctor for help. This is for the safety consideration.  

Lamivudine Usage: Lamivudine (Lamivudin) is used to produce preparations that can cure HIV infections. It belongs to  nucleoside reverse transcriptase inhibitors (NRTIs). 

Certificate of Analysis—Lamivudine

Testing Item

Standard

Result

Appearance  

Lamivudine

White   or off white crystalline powder

Complies

Solubility

Soluble in water, sparingly soluble in   methanol.

Complies

Identification A by   HPLC

The retention time of the major peak   corresponds to that of system suitability solution, as obtained in the test   for limit of Lamivudine Enantiomer.

Complies

Identification B by IR-- Lamivudine

The Infrared absorption should exhibit maxima   only at the same wavelengths as the standard

Complies

Melting Point

174°C ~ 178°C

176.4°C ~ 177.4°C

Water   (KF)

≤   0.2%

0.05%

Specific Optical Rotation

-97°   ~ -99°

-98°

Residual on Ignition

≤   0.1%

0.02%

Heavy   Metals

≤   20ppm

<   20ppm

Absorptivity

≤   0.0015

0.0002

Related   Substances

a).   Cytosine

b).   Uracil

c).   RRT0.4

d).   RRT0.9

e).   Salicylic Acid

f).   Individual impurity

g).   Total Impurities

 

≤   0.1%

≤   0.1%

≤   0.3%

≤   0.2%

≤   0.1%

≤   0.1%

≤   0.6%

 

0.007%

Not Detected

0.09%

0.05%

Not Detected

0.02%

0.17%

Enantiomeric   Impurity

(HPLC)

≤   0.3%

Not Detected

Limit   of Residual Solvent

Alcohol

Isopropyl   Acetate

Methanol

Triethylamine

Isopropyl   Alcohol

Ethyl   Acetate

Toluene

Dichloromethane

Normal   Hexane

Total   Residual Solvents

 

≤   0.2%

≤   0.2%

≤   0.1%

≤   0.1%

≤   0.5%

≤   0.5%

≤   0.089%

≤   0.06%

≤   0.029%

≤   0.3%

 

ND

ND

ND

ND

0.113%

ND

ND

ND

ND

0.113%

Content   (Lamivudine)

98%~102%,  

anhydrous   and solvent-free basis

99.9%

 

Top Quality, Pure Lamivudine Powder;  Lamivudine Raw Material Suppliers in China. Lamivudine API Manufacturers. 


Related similar product you may interested:    

1.Zidovudine or Zidovudin BP EP USP CAS 30516-87-1

2.Lamivudine or Lamivudin BP EP USP CAS 134678-17-4



If you are looking for the lamivudine or lamivudin bp ep usp cas 134678-17-4, welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.

Related Products

Send your message to us

Services & Products
Resources, Geology & Exploration
Hydrogeology
Drilling
Geophysics
Environmental & geotechnical services
Hydrogeology
Contact Us
Skype: frankrenful2002
E-Mail: frank_feng@fengchengroup.com
Tel: +86-186-7846 1007
WECHAT: +86-18678461007
WHATSAPP: +86-18678461007
Add: Room 1101, 5th Building, No.168 Shenzhen Road, Qingdao, China
Feedback
Contact Online