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Isoniazid or Isoniazide BP EP USP CAS 54-85-3

Isoniazid or Isoniazide BP EP USP CAS 54-85-3

Isoniazid or Isoniazide BP EP USP CAS 54-85-3 Product Name: Isoniazid Synonyms: Isoniazide, Isoniazidum CAS Number: 54-85-3 Characteristics: white or whitish crystalline powder Assay: 98.0%~102.0%, 99.0%~101.0% Formula: C6H7N3O Package: 25Kg/Cardboard Drum Usage: Isoniazid (Isoniazide) is mainly...

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Isoniazid or Isoniazide BP EP USP CAS 54-85-3                                             Isoniazid or Isoniazide BP EP USP picture.jpg

1.Product Name:  Isoniazid

2.Synonyms: Isoniazide, Isoniazidum

3.CAS Number: 54-85-3

4.Characteristics: white or whitish crystalline powder

5.Assay:  98.0%~102.0%,  99.0%~101.0% Isoniazid

6.Formula:     C6H7N3O

7.Structure

Isoniazid or Isoniazide BP EP USP formula.gif

8.Package: 25Kg/Fiber DrumCardboard DrumPaper Drum


Description:

Isoniazid is a kind of Anti-bacterial substance, which is used primarily as a tuberculostatic. Till now, Isoniazide is still a choice for the tuberculosis treatment.

Isoniazid is workable when fight against organisms of the genus Mycobacterium, especially M. tuberculosis, M. bovis and M. kansasii. Isoniazid is a highly specific pharmaceutical raw material. It is ineffective against other microorganisms. Isoniazid is bactericidal to rapidly-dividing mycobacteria, but is bacteriostatic if the mycobacterium is slow-growing. Isoniazid can be used in conjunction with other anti-tuberculosis medicines. Tuberculosis may become resistant to isoniazid if used alone. 


Usage: Isoniazid (Isoniazide) is mainly been given orally to fight against active tuberculosis (TB) infections.

Preparations like Isoniazid Tablets, Isoniazid Syrup, Isoniazid Capsules are already been produced in large scale. And the combination Rifampin and Isoniazid Capsules, Rifampin, Isoniazid, and Pyrazinamide Tablets, Rifampin, Isoniazid, Pyrazinamide, and Ethambutol Hydrochloride Tablets, etc. 


Isoniazid Mechanism of Action:

Isoniazid is a prodrug. It must be activated by bacterial catalase. Once activated, Isoniazid will provent mycoloic acids synthesis. Mycoloic acids is a crucial bacterial cell wall component. At therapeutic level, Isoniazid is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms. Specifically, Isoniazid will effect InhA by making a covalent adduct with the NAD cofactor.

Other Names:

4-pyridinecarbohydrazide, Pyridine-4-carboxylic acid hydrazide, Isonicotinylhydrazide


Certificate of Analysis of Isoniazid

Testing Item

Standard

Result

Appearance

Isoniazid

Colorless   crystals, white or whitish crystalline powder

Complies

Solubility

Should   Comply

Complies

Melting   Range

170~173

171

Identification -- Isoniazid

Should   Comply

Complies

PH

6.0~8.0

6.9

Clarity   of solution

Not   more than No.1 cloudy standard solution

Clear

Color   of solution

Not   more deeper than comparative solution

Complies

Dissocialative   Hydrazine

Should   comply

Complies

Loss   on drying

≤0.5%

0.1%

Related   Substances

Single   Impurity≤0.35%

Not   Detected

Total   Impurity≤1.0%

Not   Detected


Residue   on ignition

≤0.1%

<0.1%

Heavy   Metal

≤0.001%

<0.001%

Assay   (Isoniazid)

98.0%~102.0%

99.85%

 

Top Quality, Pure Isoniazid Powder;  Isoniazid Raw Material Suppliers in China. Isoniazid API Manufacturers. 


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Isoniazid Or Isoniazide BP EP USP CAS 54-85-3




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