Clotrimazole Raw Material BP USP CAS 23593-75-1
Clotrimazole Raw Material BP USP CAS 23593-75-1 Product Name: Clotrimazole Synonyms: Clotrimazolum, Clotrimazol. CAS Number: 23593-75-1 Characteristics: A white or light yellow crystalline powder. Soluble in alcohol , in methylene chloride, and in chloroform. Practically insoluble in water. Assay: 98% ~ 102%...
Clotrimazole BP USP CAS 23593-75-1
Product Name: Clotrimazole
Synonyms: Clotrimazolum, Clotrimazol.
CAS Number: 23593-75-1
Chemical Name: 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole
Characteristics: A white or light yellow crystalline powder. Soluble in alcohol , in methylene chloride, and in chloroform. Practically insoluble in water.
Assay: 98% ~ 102% on dried basis. / 98.5% ~ 100.5% Clotrimazole
Standard: USP, BP, EP, CP
Clotrimazole is an imidazole derivative. It is a broad-spectrum substance with antimycotic property. Clotrimazole will inhibit bio-synthesis of the sterol ergostol, which is an important component of fungal cell membranes. This action leads to increased membrane permeability and apparent disruption of enzyme systems.
The combination of Betamethasone and clotrimazole is widely used for the treatment of cutaneous tinea infections. Recent research shows that the minimum fungicidal concentration of clotrimazole will cause the leakage of intracellular phosphorous compounds into the ambient medium with concomitant breakdown of cellular nucleic acids, and accelerated potassium etflux. There above 2 effects happen very quickly and extensively. Clotrimazole will stop the dividing and growing of organisms.
Clotrimazole is poorly and erratically absorbed orally, and minimal vaginal or topical absorption.
As a professional China Clotrimazole Raw Material supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Clotrimazole API from China for almost 10 years.
Clotrimazole Mechanism of Action:
Clotrimazole interacts with yeast 14-α demethylase, a cytochrome P-450 enzyme. It is a substance which will convert lanosterol to ergosterol. By this way, Clotrimazole finally inhibits ergosterol synthesis, causing increased cellular permeability.
If overdosed with Clotrimazole:
There can be blistering, peeling, erythema, stinging, and general irritation of the skin, and cramps.
Clotrimazole (Clotrimazolum, Clotrimazol) is Anti-fungal material with big range of spectrum. It is very effective to Fungal Skin Infections. The most easily found Anti-fungal drug in the drug stores.
Clotrimazole can be used independently or together with other APIs.
The most famous final product is “Clotrimazole Cream”.
There are also Clotrimazole Lotion, Clotrimazole Tablets, Clotrimazole Lozenges in our daily use medicines. It can also be sued together with Batamethasone Dipropionate to make other preparations.
Storage: Cool and dry place. Or in normal house temperature. Avoid direct sunlight.
Certificate of Analysis: Clotrimazole (Clotrimazolum, Clotrimazol)
White to pale yellow crystalline powder
1. Infrared absorption: The IR spectrum of sample, exhibits maxima only at the same wavelength as that a similar preparation of USP Clotrimazole RS.
2.TLC Identification Test: The Rf value of the principal spot obtained from the test solution complies with that obtained from the standard solution.
90% Pass 200 Mesh
Loss on Drying
Residue on Ignition
Related compound A
Each unknown impurity≤ 0.2%
Total impurity≤ 0.5%
98.5% ~ 100.5%
If swallowed, get medical help or contact a Poison Control Center immediately.
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