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Clotrimazole Raw Material BP USP CAS 23593-75-1

Clotrimazole Raw Material BP USP CAS 23593-75-1

Clotrimazole Raw Material BP USP CAS 23593-75-1 Product Name: Clotrimazole Synonyms: Clotrimazolum, Clotrimazol. CAS Number: 23593-75-1 Characteristics: A white or light yellow crystalline powder. Soluble in alcohol , in methylene chloride, and in chloroform. Practically insoluble in water. Assay: 98% ~ 102%...

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Clotrimazole BP USP CAS 23593-75-1                                             Clotrimazole Raw Material BP USP API.jpg

Product Name:  Clotrimazole

Synonyms:  Clotrimazolum, Clotrimazol.

CAS Number: 23593-75-1

Chemical Name: 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole

Characteristics: A white or light yellow crystalline powder. Soluble in alcohol , in methylene chloride, and in chloroform. Practically insoluble in water.

Assay:  98% ~ 102% on dried basis. / 98.5% ~ 100.5% Clotrimazole

Standard:  USP, BP, EP, CP

Formula: C22H17ClN2     

Clotrimazole Raw Material BP USP formula.gif

Clotrimazole Description:

Clotrimazole  is an imidazole derivative. It is a broad-spectrum substance with antimycotic property. Clotrimazole will inhibit bio-synthesis of the sterol ergostol, which is an important component of fungal cell membranes. This action leads to increased membrane permeability and apparent disruption of enzyme systems.

The combination of Betamethasone and clotrimazole is widely used  for the treatment of  cutaneous tinea infections. Recent research shows that the minimum fungicidal concentration of clotrimazole will cause the leakage of intracellular phosphorous compounds into the ambient medium with concomitant breakdown of cellular nucleic acids, and accelerated potassium etflux. There above 2 effects happen very quickly and extensively. Clotrimazole will stop the dividing and growing of organisms.


Clotrimazole is poorly and erratically absorbed orally, and minimal vaginal or topical absorption.

 

As a professional China Clotrimazole Raw Material supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Clotrimazole API from China for almost 10 years.

 

Clotrimazole Mechanism of Action:

Clotrimazole interacts with yeast 14-α demethylase, a cytochrome P-450 enzyme. It is a substance which will convert lanosterol to ergosterol. By this way, Clotrimazole finally inhibits ergosterol synthesis, causing increased cellular permeability.

If overdosed with Clotrimazole:

There can be blistering, peeling, erythema, stinging, and general irritation of the skin, and cramps.


Clotrimazole Usage: 

Clotrimazole (Clotrimazolum, Clotrimazol) is Anti-fungal material with big range of spectrum. It is very effective to Fungal Skin Infections. The most easily found Anti-fungal drug in the drug stores.

Clotrimazole can be used independently or together with other APIs.

The most famous final product is “Clotrimazole Cream”.

There are also Clotrimazole Lotion, Clotrimazole Tablets, Clotrimazole Lozenges in our daily use medicines. It can also be sued together with Batamethasone Dipropionate to make other preparations.

 

Package: 25.0Kgs/Paper Drum, 25Kg/Fiber DrumCardboard DrumPaper Drum

Storage: Cool and dry place. Or in normal house temperature. Avoid direct sunlight. 

Certificate of Analysis: Clotrimazole (Clotrimazolum, Clotrimazol)

Testing Item

Standard

Appearance

White to pale yellow crystalline powder

Identification

(Clotrimazole)

1.   Infrared absorption: The IR spectrum of sample, exhibits maxima only at the   same wavelength as that a similar preparation of USP Clotrimazole RS.

2.TLC   Identification Test: The Rf value of the principal spot obtained from the   test solution complies with that obtained from the standard solution.

Solubility

Complies

Particle   Size

90%   Pass 200 Mesh

Loss   on Drying

≤   0.5%

Residue   on Ignition

≤   0.1%

Heavy   Metals

≤   0.001%

Imidazole

≤   0.2%

Residue   Solvent

Benzene≤   2ppm
  Toluene≤ 890ppm

Related   compound A

(O-Chlorophenyl)Diphenylmethanol≤   0.2%
  Each known impurity≤ 0.2%

Each   unknown impurity≤ 0.2%

Total   impurity≤ 0.5%

Assay   (Clotrimazole)

98.5%   ~ 100.5%

 

Keep out of reach of children to avoid accidental ingestion. If swallowed, get medical help or contact a Poison Control Center immediately.

Top Quality, Pure Clotrimazole Powder;  Clotrimazole Raw Material Supplier in China. Clotrimazole API Manufacturer. 


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Clotrimazole Raw Material BP USP CAS 23593-75-1




If you are looking for the Clotrimazole Raw Material BP USP CAS 23593-75-1, welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.

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