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Vitamin B2 Powder ( Riboflavin ) Raw Material, API CAS 83-88-5

Vitamin B2 Powder ( Riboflavin ) Raw Material, API CAS 83-88-5

Vitamin B2 Powder ( Riboflavin ) Raw Material, API CAS 83-88-5 Product Name: Vitamin B2 Powder, Riboflavin Synonyms: RIBOFLAVINE CAS No.: 83-88-5 Characteristics: Yellow to orange-yellow, crystalline powder Types as following: Riboflavin(Vitamin B2)80% SD, Feed Grade Riboflavin(Vitamin B2)Food Grade, Food Grade...

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Vitamin B2 Powder ( Riboflavin ) raw material API CAS 83-88-5

Vitamin B2 Powder ( Riboflavin ) Raw Material, API.jpg

Product Name: Vitamin B2 Powder, Riboflavin

Synonyms:  RIBOFLAVINE

CAS No.: 83-88-5

Characteristics: Yellow to orange-yellow, crystalline powder

Types as following:

Riboflavin (Vitamin B2) 80% SD, Feed Grade

Riboflavin (Vitamin B2) Food Grade, Food Grade

Riboflavin (Vitamin B2) 95 DC, Pharmaceutical Grade

Formula:  C17H20N4O6

Structure:

Vitamin B2 Powder ( Riboflavin ) Raw Material, API formula.jpg


Package: 25Kgs/Carton; 25Kgs/Drum

Storage: In well Sealed Containers, Stored in Cool ,dry place and keep from light.

HSCODE: 29362300

KEY Words: Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade.

Description:

Vitamin B2 Powder, also known as Riboflavin, is a water-soluble vitamin. Every one  needs a daily dosage of Vitamin B2 because Riboflavin can't be stored in our body. Vitamin B2 is very important for energy production in our body. Riboflavin, itself, represents a crucial nutrient in our diet.

Vitamin B2, plays a significant role in the production of energy. Riboflavin helps in the conversion of carbohydrates to sugar, which is the energy substance for many functions of the body. Riboflavin also plays a key role in the electron transportation chain which creats cellular energy. Furthermore, Vitamin B2 helps in the processing of some amino acids and fats. Riboflavin can also serve as an anti-oxidant, slowing our aging speed.

Riboflavin  or vitamin B2 is a nutritional factor which can be found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables, etc. The richest natural source for Riboflavin is yeast. Vitamin B2 presents in the free form only in eye retina, whey, and in urine; Riboflavin's principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.

Vitamin B2 (Riboflavin) belongs to the class of organic compounds which is known as flavins. These are compounds which contains a flavin (7,8-dimethyl-benzo[g]pteridine-2,4-dione) moiety, with a structure characterized by an isoalloaxzine tricyclic ring.

Many Vitamins are naturally occurring substances which are necessary for many processes in body system. Riboflavin plays an important role for the maintenance of many tissues of our body. Pharmaceutically, Vitamin B2 is used to treat or prevent deficiencies of Riboflavin.

Riboflavin or vitamin B2 is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health. Just as the other vitamin B series, Riboflavin supports energy production by aiding in the metabolising of carbohydrates, fats, and some proteins. Riboflavin is needed in the process of red blood cell formation, antibody production. Vitamin B2 also regulates human growth and reproduction. Riboflavin is crucial for the health of our skin, nails, hair growth. Vitamin B2 also helps to prevent or cure many kinds of eye disorders, even works for some cataracts.

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Riboflavin, also known as vitamin B2 or additive E101, is an easily absorbed micronutrient with an important role in maintaining health in humans and animals. Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade is the central component of the cofactors FAD and FMN. Further more, it is therefore required by all flavoproteins. Thus, Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade is required for a lot of cellular processes. And it plays a crucial role in energy metabolism, and for the metabolism of fats, ketone bodies, carbohydrates, and proteins, etc.

Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade exist in Milk, cheese, leafy green vegetables, liver, kidneys, legumes, tomatoes, yeast, mushrooms, and almonds. But exposure to light will destroy Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade.

The name "riboflavin" comes from "ribose" (the sugar whose reduced form, ribitol, forms part of its structure) and "flavin", the ring-moiety which imparts the yellow color to the oxidized molecule (from Latin flavus, "yellow"). The reduced form, which occurs in metabolism along with the oxidized form, is colorless.

Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade is better known visually as the vitamin which will impart the orange color to solid B-vitamin preparations, the yellow color to vitamin supplement solutions and the unusual fluorescent-yellow color to the urine of persons who supplement with high-dose B-complex preparations (no other vitamin imparts any color to urine).

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Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade is the precursor of the coenzymes, flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). They both act as electron carriers in several oxidation-reduction reactions involved in energy production and in numerous metabolic pathways.

Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade deficiency will affect multiple pathways in the metabolism of vitamin B6, folate, niacin, and iron.

Lacking of Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade has been linked to preeclampsia in pregnant women. This condition may progress to eclampsia and lead to severe bleeding or even life-threatening. The risk of preeclampsia has recently been associated with the presence of a genetic variant (C677T) in the methylenetetrahydrofolate reductase gene. This gene codes for the MTHFR enzyme, which is FAD-dependent.

Oxidative stress may result in opacification of the eye lens, leading to cataracts in older individuals. While the results of some observational studies are promising, intervention studies are needed to assess a potential benefit of riboflavin in the prevention of cataracts.

Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade (in the form, FAD) is badly needed as a cofactor for some important folate-metabolizing enzymes. A low status of riboflavin might interfere with the metabolism of folate, particularly in individuals homozygous for the MTHFR C677T gene variant; these individuals exhibit a higher risk of cardiovascular disease. Emerging evidence from intervention trials supports a protective role for riboflavin against hypertension in individuals with the MTHFR 677TT genotype.

Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade has been evaluated as a prophylactic agent in researches with children and adults who are suffering from migraine headache. Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade has been proven to have the ability of decreasing the frequency and severity of headache attacks in adults but not in children.

Case reports have shown that patients with autosomal recessive disorders of Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade metabolism might benefit from riboflavin supplementation.

Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade has been evaluated as a potential adjunct therapy in cancer and certain eye disorders.

Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade is a water-soluble B vitamin. In our body system, it is primarily found as an integral component of the coenzymes, flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). Coenzymes derived from Vitamin B2, Riboflavin powder Raw Material, API food grade and Pharmaceutical Grade are termed flavocoenzymes, and enzymes which use a flavocoenzyme are called flavoproteins.

 

Function

Oxidation-reduction (redox) reactions

Living organisms derive most of their energy from redox reactions, which are processes that involve the transfer of electrons. Flavocoenzymes participate in redox reactions in numerous metabolic pathways (3). They are critical for the metabolism of carbohydrates, lipids, and proteins. FAD is part of the electron transport (respiratory) chain, which is central to energy production. In conjunction with cytochrome P-450, flavocoenzymes also participate in the metabolism of drugs and toxins (4).

 

Antioxidant functions

Glutathione reductase is an FAD-dependent enzyme that participates in the redox cycle of glutathione. The glutathione redox cycle plays a major role in protecting organisms from reactive oxygen species, such as hydroperoxides. Glutathione reductase (GR) requires FAD to regenerate two molecules of reduced glutathione from oxidized glutathione. Riboflavin deficiency has been associated with increased oxidative stress (4). Measurement of GR activity in red blood cells is commonly used to assess riboflavin nutritional status (5). The erythrocyte glutathione reductase activation coefficient (EGRac) assay assesses riboflavin status by measuring the activity of GR before and after in vitro reactivation with its prosthetic group FAD; EGRac is calculated as the ratio of FAD-stimulated to unstimulated enzyme activity and indicates the degree of tissue saturation with riboflavin. EGRac is thus a functional measure of riboflavin status and has shown to be effective in reflecting biomarker status from severe deficiency to normal status

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Vitamin B2, also called riboflavin, is one of 8 B vitamins. All B vitamins help the body to convert food (carbohydrates) into fuel (glucose), which is used to produce energy. These B vitamins, often referred to as B-complex vitamins, also help the body metabolize fats and protein. B complex vitamins are necessary for a healthy liver, skin, hair, and eyes. They also help the nervous system function properly.

 

All B vitamins are water soluble, meaning the body does not store them.

 

In addition to producing energy for the body, riboflavin works as an antioxidant, fighting damaging particles in the body known as free radicals. Free radicals can damage cells and DNA, and may contribute to the aging process, as well as the development of a number of health conditions, such as heart disease and cancer. Antioxidants, such as riboflavin, can fight free radicals and may reduce or help prevent some of the damage they cause.

 

Riboflavin is also needed to help the body change vitamin B6 and folate into forms it can use. It is also important for growth and red blood cell production.

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Vitamin B2 Mechanism of Action:

It binds to riboflavin-related hydrogenase, kinase, synthase, etc. Vitamin B2 is the precursor of flavin mononucleotide and flavin adenine dinucleotide. Riboflavin's antioxidant activity is mainly derived from Vitamin B2's role as a precursor of FAD and the role of this cofactor in the production of the antioxidant reduced glutathione, which is the cofactor of the selenium containing glutathione peroxidases among other things.

Vitamin B2 Side Effects:

Although riboflavin has so many benefits, there still can be some unwanted effects. Vitamin B2 Powder may result in a more yellow urine than usual, especially if it is largely dosed. We can expect this, and it is not harmful to be alarmed. Usually, however, Vitamin B2 does not cause adverse effects. But for our safety, it is better to tell your health care professional if there is other unusual effects.

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As a professional China Riboflavin or Vitamin B2 raw material API food grade and pharma grade supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Riboflavin or Vitamin B2 food grade and pharma grade raw material from China for almost 10 years. 

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Vitamin B2 deficiency symptoms (Deficiency Symptoms Of Riboflavin):

Deficiency of Vitamin B2 may hamper the metabolism of carbohydrates, fats, and proteins. All the above nutritional elements will need Riboflavin for their complete metabolism.

Some of the deficiency of vitamin B2 may cause 1.bloodshot eyes, or Irritability in the eyes. 2.high sensitivity to light,  Extreme and unusual sensitivity to light; 3.A burning sensation in the eyes, 4. Chapped lips,  parched lips 5. Inflammation and infection in the mouth or throat, 6. A sore tongue.

There can be other common symptoms such as dull or oily hair, premature wrinkles, and split nails.

Vitamin B2 deficiency may cause adrenal glands improper function, which will cause various problems like chronic fatigue syndrome, anemia, etc. Riboflavin deficiency is thought to be the main reason for the fatal condition of preeclampsia in pregnant women.

Vitamin B2 deficiency mainly manifests as skin lesions, especially over the tongue and around mouth corners. If not treated in time, it will result in a swollen tongue, or even some nerve problems.

Vitamin B2 deficiency diseases:

Deficiency Riboflavin, which is known as ariboflavinosis, is unlikely happen without the simultaneous deficiency of other nutrients. Several months of riboflavin deprivation may ended in skin cracks, mouth corners problems, lip fissures, tongue problems.

B2 vitamin benefits (vitamin b2 function), Health Benefits Of Riboflavin:

Riboflavin is a vitamin, which plays an important role overall human health. The major health benefits are as following:

1.Energy Production

2.Increases Blood Circulation-- Riboflavin B2 is crucial for the formation of antibodies and red blood cells.

3.Promotes Body Growth and Development

Riboflavin is essential for proper growth & development of our reproductive organs, and the growth of tissues like skin, eyes, connective tissue, nervous system, immune system, mucous membranes, etc.

4. Vitamin B2 also ensures healthy skin, nails, and hair.

Finished Drugs in the market:

Riboflavin, or Vitamin B2 tablets is the most popular finished drug. There are also riboflavin oral capsule.

COA of Vitamin B2 Raw material, Riboflavin


Testing Item

Standard

Result

Appearance
 Riboflavin

Yellow    to orange-yellow, crystalline powder

Complies

Identification
 Vitamin    B2

A    solution in water at a concentration of 1% appears pale greenish yellow by    transmitted light, and has an inense yellowish green fluorescence which    disappears upon the addition of mineral acids or alkalies

Complies

Specific    Rotation

-115~-135

-126

Loss    on drying

≤1.5%

0.19%

Residue    on ignition

≤0.3%

0.1%

Limit    of Lumiflavin

The    absorption (at 440nm) of a solution in alcohol-free chloroform at a    concentration of 2.5mg/ml does not exceed 0.025

Complies

Organic    volatile impurities

Should    comply

Complies

Assay    (Riboflavin)

98.0%~102.0%    (Vitamin B2)

100.42%

CONCLUSION

Comply    with USP34 Standard

Top Quality, China Pure Riboflavin or Vitamin B2 raw material food grade and pharma grade factory and Suppliers in China. China Riboflavin or Vitamin B2 API food grade and pharma grade Manufacturers in China. 


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