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Vitamin B1 Powder ( Thiamine Hydrochloride Or Hcl, Thiamine Mononitrate, Thiamine Nitrate )

Vitamin B1 Powder ( Thiamine Hydrochloride Or Hcl, Thiamine Mononitrate, Thiamine Nitrate )

Vitamin B1 Powder ( Thiamine Hydrochloride or Hcl, Thiamine Mononitrate, Thiamine Nitrate ) KEY Words: Thiamine Hydrochloride, Thiamine Hcl, Thiamine Mononitrate, Vitamin B1 Hcl, Thiamine Nitrate Description: Thiamine, also called Vitamin B1, is an imoprtant nutrient needed for carbohydrate...

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Vitamin B1 Powder ( Thiamine Hydrochloride or Hcl, Thiamine Mononitrate, Thiamine Nitrate )

Vitamin B1 Powder ( Thiamine Hydrochloride Or Hcl, Thiamine Mononitrate, Thiamine Nitrate ).jpg

Product    Name:

Vitamin B1 Powder, Thiamine

Synonyms:

Thiamine Hydrochloride
 Thiamine Hcl
 Vitamin B1 Hcl

Thiamine Mononitrate
 Vitamin B1 Mononitrate
 Thiamine Nitrate
 Vitamin B1 Nitrate

Specifications:

BP,    EP, USP

BP,    EP, USP

CAS

67-03-8

532-43-4

Characteristics:

White crystalline powder

White    or almost white, crystalline powder or small, colorless crystals

Formula:

C12H18Cl2N4OS

C12H17N5O4S

Structure:

30.jpg

31.jpg

Package:

25Kgs/Drum;    25Kgs/Carton

25Kgs/Drum;    25Kgs/Carton


KEY Words: Thiamine Hydrochloride, Thiamine Hcl, Thiamine Mononitrate, Vitamin B1 Hcl, Thiamine Nitrate Powder API, Raw Material

Description of  Thiamine Hydrochloride (Vitamin B1 Hcl):

Thiamine, also called Vitamin B1, is an imoprtant nutrient needed for carbohydrate metabolism; Vitamin B1 also involved in nerve function.

Commonly, there are 2 salts exist: Thiamine Hydrochloride (Vitamin B1 Hcl), Thiamine Mononitrate (Vitamin B1 Nitrate).

Thiamine Hydrochloride, Chemical Name: 3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chloride hydrochloride

Thiamine Nitrate, Chemical Name 3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium nitrate.

Dietary sources of Vitamin B1 like whole grains, meat products, vegetables, milk, legumes and fruit. It also present in rice husks and yeast. Chronic deficiency of Vitamin B1 Hcl may cause some problems such as neurological impairment, bariberi, Wernicke-Korsakoff syndrome, etc.

Thiamine Hydrochloride (Vitamin B1 Hcl), Thiamine Nitrate (Vitamin B1 Mononitrate) are vitamins with antioxidant activity and erythropoietic properties. It will also has ability like cognition-and mood-modulatory, anti-atherosclerotic.

Thiamine Hcl is proven to protect against lead-induced lipid peroxidation in liver and kidney. Vitamin B1 Hydrochloride deficiency may result in selective neuronal death in some animal trials. Neuronal death is highly associated with increased free radical production, which suggests that oxidative stress plays an important role in brain damage associated with thiamine Hydrochloride deficiency. Thiamine Hcl plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. This effect may promote atherosclerosis. Vitamin B1 Hydrochloride (Thiamine Hcl) inhibits this effect of glucose on endothelial cells.

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With the chemical name, 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride, Thiamine Hydrochloride or Hcl powder raw material API is the hydrochloride salt form of thiamine, a vitamin which is essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Upon hydrolysis, thiamine hydrochloride is phosphorylated by thiamine diphosphokinase to form active thiamine pyrophosphate, also known as cocarboxylase. TPP is a coenzyme for many enzymatic activities involving fatty acid, amino acid and carbohydrate metabolism.

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Description of Thiamine Nitrate (Vitamin B1 Mononitrate): 

Thiamine Nitrate (Vitamin B1 Mononitrate) is found in foods like cereals, whole grains, meat, nuts, beans, and peas. Thiamine Mononitrate is crucial in the breakdown of carbohydrates from foods into products which is deeply needed by our body.

Vitamin B1 Mononitrate is used to cure or for the prevention vitamin B1 deficiency. Thiamine Mononitrate injection is the popular preparation used to treat beriberi, which is a serious condition caused by prolonged lack of vitamin B1.

Orally taken Thiamine Mononitrate is available without a prescription. While injectable Vitamin B1 Mononitrate must be given by a healthcare professional.

Thiamine Mononitrate may also be useful for some purposes not listed in this medication guide.

Both Thiamine Hydrochloride (Vitamin B1 Hcl), Thiamine Mononitrate (Vitamin B1 Mononitrate) are soluble in water and insoluble in alcohol. They will decompose if heated.

Thiamine Mononitrate plays an important role in the process of intracellular glucose metabolism. It is widely thought that Vitamin B1 Mononitrate inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine Mononitrate also helps the body convert carbohydrates and fat into energy. Vitamin B1 Hcl is also essential for normal body growth and development. It is an essential ingredient for compound feed, and it may facilitate growth of young animals.  And Thiamine hydrochloride helps to maintain proper functioning of our heart and the nervous and digestive systems.

Although both Thiamine Hydrochloride (Vitamin B1 Hcl), Thiamine Mononitrate (Vitamin B1 Mononitrate) can't be stored in our body, once absorbed, it will be concentrated in muscle tissue.

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Thiamine mononitrate API, Raw material powder, another popular name vitamin B1, is an essential human nutrient involved in a variety of cellular processes, like the synthesis of amino acids or the use of sugars as energy. Though Thiamine mononitrate API, Raw material powder is required by the biology of all animals, it is only generated in primitive organisms like bacteria and plant life, so human beings must obtain it through food or nutritional sources. When Thiamine mononitrate API, Raw material powder is added as a supplement to foods like breakfast cereals, it is often referred to in a broader context as a B-vitamin complex. This is because its usually added in conjunction with other B vitamins, such as vitamin B2 or riboflavin, vitamin B3 or niacin, and vitamin B6 known as pyridoxine, as well as others.

 

While crucial to virtually every cellular function in the body where it is broken down into thiamin pyrophosphate, one of these areas is the proper function of the human nervous system. If there is a deficiency of Thiamine mononitrate API, Raw material powder, inflammation of nerves near the brain known as peripheral neuritis may be the bad result. hiamine mononitrate API, Raw material powder, is also vital to metabolic processes like digestion, and supplements are often prescribed to alleviate diarrhea, ulcerative colitis, and other related conditions affected by the impaired metabolism of food into energy and nutrients.

 

Considering Thiamine mononitrate API, Raw material powder exist in so many food and plant, its sources are widespread throughout the food chain. Thiamine mononitrate API, Raw material powder have a long shelf-life of up to 42 months due to the stability of the compound, and this makes it ideal choice for working as an additive in several dry foods as well as beverage powders. One of the most common places Thiamine mononitrate API, Raw material powder is added as a nutrient is in fortified, enriched flour.

 

Vitamin B1 can go by other related names on labels such as thiamine, thiamine hydrochloride or Thiamine mononitrate API, Raw material powder due to the source from which it is obtained, and it can be included in ingredients that are not listed on a label. An example of this are the compounds of carrageenan and Irish moss, which are forms of algae which contain thiamine mononitrate. Thiamine mononitrate API, Raw material powder is also a popular ingredient in a lot of cosmetics like face creams. Because Thiamine mononitrate API, Raw material powder will promote to maintain a healthy skin and our hair growth. This property allow it a dual use commercially as both a cosmetic and nutritional aid.

Evidence suggests that the Thiamine mononitrate API, Raw material powder has a wide range of helpful effects on the human body.

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Key Difference – Thiamine Mononitrate vs Thiamine Hydrochloride

Both Thiamine Mononitrate and Thiamine Hydrochloride are sources of Thiamine (vitamin B1). Thiamine mononitrate is prepared from Thiamine hydrochloride by removing chloride ion and mixing the final product with a nitric acid. This is the main difference between Thiamine mononitrate and Thiamine hydrochloride. For further differences, please contact FENGCHEN GROUP CO., LTD.

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As a professional China Thiamine Hydrochloride or Vitamin B1 Hcl, Thiamine Mononitrate or Vitamin B1 Mononitrate raw material API supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Thiamine Hydrochloride or Vitamin B1 Hcl, Thiamine Mononitrate or Vitamin B1 Mononitrate raw material API from China for almost 10 years. 


Notes:

Deficiency can result in beriberi and is a factor in alcoholic neuritis and other syndromes; Thiamine Hcl and Vitamin B1 Mononitrate can be used to fight against Vitamin B1 deficiency. With fast development of clinical pharmacology in recent years, Vitamin B1 deficiency can be treated very fast.

Thiamine Mononitrate is a stable nitrate salt form of thiamine (vitamin B1). It occurs as a white crystalline powder and is manufactured from thiamine hcl. Thiamine Mononitrate is used as a food or nutritional supplement and Vitamin B1 Mononitrate is the preferred form of the vitamin B1 for food fortification.

Vitamin B1 mononitrate is widely used in the pharmaceutical industry to fight against beriberi, general malnutrition, malabsorption, etc.

Though thiamine is found naturally in foods, Vitamin B1 mononitrate is not found. Thiamine mononitrate is mostly synthesized by removing a chloride ion from thiamin hydrochloride and mixing with nitric acid.

Thiamine hydrochloride is hygroscopic (water-absorbing) whereas the Thiamine mononitrate has almost no hygroscopic properties. Because of this property, Vitamin B1 mononitrate is the more stable form of the vitamin in fortified flours and cereals.

Mechanism of Action of Thiamine Mononitrate :

It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic flux. Thiamine is mainly the transport form of the vitamin, while the active forms are phosphorylated thiamine derivatives like Thiamine Mononitrate.

Indications:

For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.

Usage: Thiamine Mononitrate participates in formation of the coenzyme, it maintains glycometabolism and functions of the nerve and digestive systems. It is used in preventing and treating vitamin B1 deficiency, and it also helpful for therapy of neuritis and dyspepsia. Besides pharmaceutical application, Thiamine Mononitrate also can be used as food additive and feed additive.

Other usages:

Thiamine Hydrochloride (Vitamin B1 Hcl), Thiamine Mononitrate (Vitamin B1 Mononitrate) are added as a nutritional supplement in sports drinks.

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Property:

Name: Thiamine hydrochloride powder raw material, API

EINECS: 200-641-8

CAS No.: 67-03-8

Thiamine hydrochloride powder raw material, API  Solubility: 1 g/mL in water

Thiamine hydrochloride powder raw material, API  Melting Point: 250 °C (dec.)(lit.)

Formula: C12H17ClN4OS.HCl

Molecular Weight: 337.27

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COA of Thiamine Hydrochloride

Testing Item

Standard

Result

Appearance
 Thiamine    Hydrochloride

White    or almost white, crystalline powder or colorless crystals

Complies

Identification
 Thiamine    Hcl

A:    IR absorption
 B:    Reaction of chlorides

Complies
 Complies

Appearance    of solution
 Vitamin    B1 hydrochloride

Clear,    not more intense than Y7 or GY7

Complies

Absorbance    of solution
 Vitamin    B1 Hcl

≤    0.025

0.018

Limit    of nitrate

No    brown ring produced at the junction of the two layers

Complies

pH

2.7~3.3    (BP2012)
 2.7~3.4    (USP38)

2.9

Moisture

≤    5.0%

1.78%

Sulphated    Ash

≤    0.1% (BP2012)
 ≤    0.2% (USP38)

0.02%

Sulphates

≤    300ppm

<    300ppm

Chromatographic    purity

≤    1.0%

0.02%

Heavey    Metal
 Thiamine    Hcl

≤    20ppm

<20ppm

Residual    solvent (Methanol)

≤    0.3%

0.03%

Residual    solvent (Ethanol)

≤    0.5%

Not    detected

Any    single impurity

≤    0.4%

0.09%

Total    impurities

≤    1.0%

0.09%

Assay
 Thiamine    Hydrochloride

98.5%    ~ 101.0% (BP2012)
 98.0%    ~ 102.0% (USP38)

99.2%

COA  of Thiamine  Mononitrate:



Testing Item

Standard

Result

Appearance
Thiamine    Mononitrate

White    or almost white, crystalline powder or small, colorless crystals

Complies

Identification
Vitamin    B1 Mononitrate

A:    IR absorption
B:    Reaction of chlorides

Complies
Complies

Appearance    of solution
Thiamine    Mononitrate

Clear,    not more intense than Y7

Complies

pH
Vitamin    B1 Mononitrate

6.8    ~7.6 (BP2012)
6.0    ~7.5 (USP38)

7.2

Loss on Drying

≤    1.0%

0.17%

Sulphated    Ash

≤    0.1% (BP2012)
≤    0.2% (USP38)

0.02%

Chloride

≤    0.06%

<    0.06%

Chromatographic    purity

≤    1.0%

0.27%

Heavey    Metal

≤    20ppm

<20ppm

Residual    solvent (Methanol)

≤    0.3%

Not    detected

Any    single impurity

≤    1.0%

0.14%

Total    impurities

≤    1.5%

0.43%

Assay
Thiamine    Mononitrate

98.0%    ~ 101.0% (BP2012)
98.0%    ~ 102.0% (USP38)

99.6%

Top Quality, China Pure Thiamine Hydrochloride or Vitamin B1 Hcl, Thiamine Mononitrate or Vitamin B1 Mononitrate powder/substance factory in China; China Thiamine Hydrochloride or Vitamin B1 Hcl, Thiamine Mononitrate or Vitamin B1 Mononitrate Material Suppliers in China. China Thiamine Hydrochloride or Vitamin B1 Hcl, Thiamine Mononitrate or Vitamin B1 Mononitrate API Manufacturers in China. 


If you are looking for the vitamin b1 powder ( thiamine hydrochloride or hcl, thiamine mononitrate, thiamine nitrate ), welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.
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