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Tilmicosin Base CAS 108050-54-0 Tilmicosin Phosphate CAS 137330-13-3 Powder API, Raw Material

Tilmicosin Base CAS 108050-54-0 Tilmicosin Phosphate CAS 137330-13-3 Powder API, Raw Material

Tilmicosin Base CAS 108050-54-0 Tilmicosin Phosphate CAS 137330-13-3 Powder API, Raw Material Keywords: Tilmicosin, Tilmicosin Phosphate Description and usage: Tilmicosin is a macrolide antibiotic. Tilmicosin Phosphate is the Phosphate of Tilmicosin. They are used in veterinary medicine to help treat bovine respiratory...

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Tilmicosin Base CAS 108050-54-0 Tilmicosin Phosphate CAS 137330-13-3

Tilmicosin Base, Tilmicosin Phosphate Powder API, Raw Material.png

Product Name:

Tilmicosin Base

Tilmicosin Phosphate Salt

Characteristics:

Off-white to yellowish powder

Almost white or yellowish powder

CAS Number:

108050-54-0

137330-13-3

Formula:

C46H80N2O13

C46H83N2O17P

C46H80N2O13.H3PO4

Structure:

Tilmicosin Base, Tilmicosin Phosphate Powder API, Raw Material formula.png

Tilmicosin Base, Tilmicosin Phosphate Powder API, Raw Material structure.png

Package:

25Kgs/Drum

25Kg/Fiber DrumCardboard DrumPaper Drum

Keywords: Tilmicosin, Tilmicosin Phosphate Powder API, Raw Material USP BP EP

Description and usage:
Tilmicosin is a macrolide antibiotic. Tilmicosin Phosphate is the Phosphate of Tilmicosin.
They are used in veterinary medicine to help treat bovine respiratory disease and enzootic pneumonia.
In humans, Tilmicosin and Tilmicosin Phosphate causes fatal cardiotoxic effects at amounts greater than 1 milliliter when injected, something most commonly seen in veterinary personnel and farmers.

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Description of Tilmicosin Phosphate:

Tilmicosin phosphate Powder API, Raw Material USP BP EP is a macrolide antibiotic synthesized from tylosin. Nowadays, it is only for veterinary use only. Tilmicosin phosphate Powder API, Raw Material USP BP EP has an antibacterial spectrum similar to tylosin with enhanced activity against Pasteurella haemolytica, P. multocida, Actinobacillus pleuropneumoniae, mycoplasma species and other microorganisms found sensitive to this compound. Tilmicosin phosphate Powder API, Raw Material USP BP EP is suggested for treatment and prevention of pneumonia in cattle, sheep, poultry and pigs, Not show resistance and cross-resistance with other antibiotic often used in clinic.

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Tilmicosin phosphate Powder API, Raw Material USP BP EP is a salt of the semi-synthetic antibiotic derivative of desmycosin (tylosin B), a minor cometabolite of tylosin, prepared by mixing the active tilmicosin with phosphoric acid to provide improved solubility and enhanced pharmacokinetics. Tilmicosin phosphate Powder API, Raw Material USP BP EP is a broad spectrum antibiotic. It will providing good protection against Pasteurella in livestock.

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Packaging Detail:*25kg/Fiber Drum;(Standard export packing)

                                *1kg,5kg,10kg Aluminum tin/Carton;

                                 *500gm,1kg,5kg,10kg Aluminum bag/Fiber Drum;

                                  or Package of bottle,box,bag,can be customized

 

As a professional China Tilmicosin Base and Tilmicosin Phosphate Raw Material supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Tilmicosin Base and Tilmicosin Phosphate API from China in China for almost 10 years.

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Product advantages of Tilmicosin Base and Tilmicosin Phosphate:
Low toxicity, no carcinogenic, teratogenic and mutagenic effects
Can promote weight gain, improved feed conversion rate
Tissue penetration, large volume of distribution
Less medication, absorb quickly
Product antibacterial spectrum, antibacterial stronger

Product features of Tilmicosin Base and Tilmicosin Phosphate:
 1. Adopts self-developed content tilmicosin phosphatization
 2. Immune modulating function.
 3. Small dosage.
 4. Strong tissue penetration, large distribution volume.
 5. Low toxicity.
 6. Increase feed conversion ratio.


Property of Tilmicosin Base:

Name: Tilmicosin Base

CAS No.: 108050-54-0

Tilmicosin Base Density: 1.18 g/cm3

Formula: C46H80N2O13

Boiling Point: 926.6 °C at 760 mmHg

Tilmicosin Base Molecular Weight: 869.15

Flash Point: 514.2 °C

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Other names of Tilmicosin:

Tilmicosinum [INN-Latin]

Tylosin, 4A-O-de(2,6-dideoxy-3-C-methyl-alpha-L-ribo-hexopyranosyl)-20-deoxo-20-(3,5-dimethyl-1-piperidinyl)-EL 870; Tilmicosina, Micotil; Tilmicosine

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Indexes of Tilmicosin Base:

Items

SPECIFICATION

RESULT

CHARACTERS



Appearance
Tilmicosin

Off-white to yellowish powder

Complies

IDENTIFICATIONS
Tilmicosin



A

Infrared Absorption

Complies

B

HPLC

Complies

TESTS



Loss on drying

≤5.0%

3.2%

Individual related compound

≤3.0%(on dry basis)

Max.  2.2%

Total related compounds

≤10.0%(on dry basis)

7.7%

pH

3.5-7.5

3.9

ASSAY



Tilmicosin

≥ 70.0%(Tilmicosin)
     (on dry basis)

70.2%

Cis-isomer

82.0%-88.0%

86.1%

Trans-isomer

12.0%-18.0%

13.9%

Property of Tilmicosin phosphate:

Name: Tilmicosin phosphate

Chemical Name: 20-Deoxo-20-(3,5-dimethyl-1-piperidinyl)desmycosin phosphate, Tilmicosin phosphate

CAS No.: 137330-13-3

Tilmicosin phosphate Density: 1.219 g/cm3

Formula: C46H83N2O17P

Boiling Point: 926.6 °C at 760 mmHg

Tilmicosin phosphate Molecular Weight: 967.14

Tilmicosin phosphate Solubility: Soluble in ethanol, methanol, DMF or DMSO. Good water solubility.

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Other Names of Tilmicosin phosphate

ylosin,4A-O-de(2,6-dideoxy-3-C-methyl-a-L-ribo-hexopyranosyl)-20-deoxo-20-(3,5-dimethyl-1-piperidinyl)-,[20(cis)]-, phosphate (1:1) (salt); oxacyclohexadeca-11,13-diene-2,10-dione, 15-[[(6-deoxy-2,3-di-O-methyl-beta-D-allopyranosyl)oxy]methyl]-6-[[3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranosyl]oxy]-7-[2-[(3R,5S)-3,5-dimethyl-1-piperidinyl]ethyl]-16-ethyl-4-hydroxy-5,9,13-trimethyl-, (4R,5S,6S,7R,9R,11E,13E,15R,16R)-, phosphate (1:1) (salt); Tylosin, 4(sup A)-O-de(2,6-dideoxy-3-C-methyl-alpha-L-ribo-;


Indexes of Tilmicosin Phosphate:


     Testing Item

Standard

Result

Appearance
Tilmicosin Phosphate

Almost white or yellowish powder

Complies

Identification A
Tilmicosin Phosphate

The retention time of the major peak in the chromatogram of the assay preparation corresponds o that in the chromatogram of the standard preparation, as obtained in the assay.

Complies

Identification B
Tilmicosin Phosphate

Should comply with phosphate identification test.

Complies

Identification C
Tilmicosin Phosphate

IR spectra is consistent with CRS

Complies

Related substance

Any impurity≤ 3.0%

1.66%

Total Impurities≤ 10.0%

6.92%

Moisture

≤ 5.0%

4.0%

pH

5.0 ~ 8.0

6.7

Tilmicosin Cis-isomers

82.0% ~ 88.0%

88.6%

Tilmicosin Trans-isomers

12.0% ~18.0%

13.4%

Assay
(On dried Basis)

≥  75% (C46H80N2O13)

78.7%

NOTE:

1. Generally, Tilmicosin phosphate Powder API, Raw Material USP BP EP is forbidden for equus animals, laying hens.

2. Tilmicosin may irritate eyes. It may cause anaphylactic reaction. So avoid direct contact with Tilmicosin phosphate Powder API, Raw Material USP BP EP.

3. It is forbidden for intravenous injection. Cattle will be died if take intravenous injection of 5mg/kg at a time. By the way, Tilmicosin phosphate Powder API, Raw Material USP BP EP also has similar deadly danger for pigs, quadrumanas and horses.

 

Top Quality, China Pure Tilmicosin Base, Tilmicosin Phosphate Powder/Substance factory in China; China Tilmicosin Base, Tilmicosin Phosphate Raw Material Suppliers in China. China Tilmicosin Base, Tilmicosin Phosphate API Manufacturers in China. 


Related similar product you may interested:    

Tilmicosin Base CAS 108050-54-0 Powder API, Raw Material

Tilmicosin Phosphate CAS 137330-13-3 Powder API, Raw Material

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E-Mail: frank_feng@fengchengroup.com
Tel: +86-186-7846 1007
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Add: Room 1101, 5th Building, No.168 Shenzhen Road, Qingdao, China
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