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Febantel Powder API, Raw Material BP, EP, USP CAS 58306-30-2

Febantel Powder API, Raw Material BP, EP, USP CAS 58306-30-2

China Febantel Suppliers, China Febantel Manufacturers CAS 58306-30-2 Product Name: Febantel Powder API, Raw Material BP, EP, USP CAS 58306-30-2 Synonyms: Febantelum CAS Number: 58306-30-2 Characteristics: White or almost white crystalline powder Assay: 97.5% ~ 102.0% Febantel Formula: C20H22N4O6S Structure Formula: KEYWORD: Febantel Standard:...

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China Febantel Suppliers, China Febantel Manufacturers CAS 58306-30-2

Febantel Powder API, Raw Material BP, EP, USP.jpg

Product Name:  Febantel Powder API, Raw Material, BP, EP, USP

Synonyms:  Febantelum

CAS Number: 58306-30-2

Characteristics: White or almost white crystalline powder

Assay:  97.5% ~ 102.0% Febantel

Formula: C20H22N4O6S

Structure Formula:

Febantel Powder API, Raw Material BP, EP, USP formula.jpg

KEYWORD: Febantel Powder API, Raw Material, BP, EP, USP

Standard: EP7.0 Standard Febantel Powder API, Raw Material, BP, EP, USP

Package: 25Kgs/Drum

 

Description:  

Febantel is destructive to parasitic worms. It is used therapeutically in the treatment of helminthiasis animal.

Febantel is a broad spectrum anthelmintic substance. It is effective against roundworms.

Depending on the dose, Febantel also works against some tapeworms (e.g. Moniezia spp) as welll. It is not working against flukes (e.g. Fasciola hepatica adults) at the usual therapeutic dose. And Febantel is completely not working against external parasites.

Febantel is mainly given orally. It is used abundantly in pets (mostly in tablets, pills, etc. or oral suspensions) often mixed with other anthelmintics. Febantel usage in livestock is often by feed additives.

Febantel’s Efficacy against parasite depends on the delivery form and on the dose administered.

 

Febantel Powder API, Raw Material, BP, EP, USP is an imidazothiazole anthelmintic widely used in sheep, cattle and horses. It not only has a wide-spectrum of efficiency against nematodes, but also at the same time Febantel is safe for use in all stages of pregnancy. Only under one condition, it  should not be used within 7 days of bromsalans.

Febantel chemical name is (N-{-[2,3-bis-(methoxycarbonyl)-guanido]-5- (phenylthio)-phenyl}-2-methoxyacetamide). It is effective when it fights against several gastrointestinal parasites in animals. Febantel Powder API, Raw Material, BP, EP, USP is considered to be a prodrug. It undergoes hydrolytic removal of a methoxyacetyl group and cyclisation to yield the benzimidazole, fenbendazole.

 

Other information: As a phenylguanidine anthelmintic, Febantel is an almost colorless powder. It is insoluble in water and alcohol. Chemically and Structurally, Febantel is related to the benzimidazoles.

Because Febantel will be at least partially metabolized to Fenbendazole and Oxibendazole, it is sometimes considered to be categorized as a probenzimidazole substances.

 

As a professional China Febantel Powder API, Raw Material, BP, EP, USP supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Febantel Powder API, Raw Material, BP, EP, USP from China in China for almost 10 years.


Usage:

Febantel will be made into tablets, pills or oral suspensions to help animal fight against worms.

It is anthelminthic drug.

 

Now, Febantel is popularly applied to combat Tapeworms in dogs, Hookworms in dogs, Whipworms in dogs. It is also useful in some other conditions.

 

Febantel Properties:

Name: Febantel

EINECS: 261-205-0

Febantel CAS No.: 58306-30-2

Density: 1.31 g/cm3

Febantel Melting Point: 129-130 °C

Formula: C20H22N4O6S

Molecular Weight: 446.48

Appearance: white to off-white solid

Synonyms: Carbamicacid, [[2-[(methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]bis-,dimethyl ester (9CI); Rintal;

 

Febantel Safety information:

By ingestion, Febantel Powder API, Raw Material, BP, EP, USP is moderately toxic. When heated to decomposition Febantel will emit very toxic fumes of NOx and SOx.

R22: Harmful if swallowed

 

Acute toxicity:

Normally, taken orally, Febantel is of low toxicity for the rat, mouse, dog, etc. It was somewhat a little more toxic to the rabbit. By inhalation exposure, Febantel Powder API, Raw Material, BP, EP, USP is of low acute toxicity for the rat. By dermal exposure, Fenbantel is also of low acute toxicity for rabbit.

 

Febantel Mechanism of Action and Pharmacology:

Febantel will block the glucose uptake. It will also interfere parasite’s energy metabolism.

Febantel is able to inhibit worm’s fumarate reductase, as a result, glucose uptake get blocked. The majority of the activity is believed to be derived from the active metabolites, fenbendazole and oxfendazole.


Storage of Febantel:

Please keep Febantel at room temperature, avoid heat and direct light.

Do not freeze Febantel Powder API, Raw Material, BP, EP, USP unless required by package insert. Keep Febantel away from children’s reach.

Do not flush Febantel Powder API, Raw Material, BP, EP, USP down the toilet or pour them into drainage unless instructed to do so. Improper discarded Febantel may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Febantel.

 

Febantel Side Effects:

Adverse Effects: When use Febantel at recommended dosages in horses, adverse reactions are unlikely to happen. Anaphylaxis is a possible side effect, but there is no document which will support this. At very high doses (about eight times), a self-limiting diarrhea can be the side effect.

 

Overdosage/Toxicity: In horses, Febantel has a reported 40X margin of safety after a single oral dose. Slightly decreased red blood cell counts, hemoglobin and hematocrit may happenmay after 21 days after administration. Repeated doses of eight times recommended will only cause a self-limiting diarrhea.


COA of Febantel

Name    of Product

Febantel

Testing Item

Standard

Result

Appearance

White    or almost white crystalline powder

Complies

Identification
 (Febantel)

Should comply with the spectrum of    Febantel CRS.

Complies

Related Substances

Impurity    A ≤ 0.1%

< 0.05%

Impurity    B ≤ 0.1%

< 0.05%

Impurity    C ≤ 0.1%

< 0.05%

Unspecified    Impurity ≤ 0.2%

< 0.05%

Total    Impurities ≤ 0.5%

< 0.05%

Loss    on drying

≤    0.5%

0.1%

Sulphated Ash

≤    0.1%

0.08%

Heavy    Metal

≤    20ppm

<    20ppm

Assay    (Febantel)

97.5%    ~ 102.0% On dried basis

99.9%

Foreign Names

Febantelum (Latin)

 

Top Quality, China Pure Febantel Powder/Substance factory in China; China Febantel Raw Material Supplier in China. China Febantel API Manufacturer in China.


Related similar product you may interested:    

Febantel Powder API, Raw Material BP, EP, USP CAS 58306-30-2

If you are looking for the Febantel Powder API, Raw Material BP, EP, USP CAS 58306-30-2, welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.
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