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Apramycin Sulfate or Apramycin Sulphate API, Raw Material CAS 41194-16-5

Apramycin Sulfate or Apramycin Sulphate API, Raw Material CAS 41194-16-5

Apramycin Sulfate or Apramycin Sulphate API, Raw Material CAS 41194-16-5 Product Name: Apramycin Sulfate (Apramycin Sulphate) CAS Number: 41194-16-5 or 65710-07-8 Characteristics: A light brown powder or granular material. Solubility: Apramycin Sulfate (Apramycin Sulphate) will easily dissolved in water, but will...

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Apramycin Sulfate or Apramycin Sulphate API, Raw Material CAS 41194-16-5                                   Apramycin Sulfate or Apramycin Sulphate API, Raw Material.jpg

Product Name:  Apramycin Sulfate (Apramycin Sulphate) API, Raw Material

Synonyms: Apramycin Sulfate Salt

CAS Number: 41194-16-5 or  65710-07-8

Characteristics: A light brown powder or granular material.

Solubility: Apramycin Sulfate (Apramycin Sulphate) will easily dissolved in water, but will not dissolved in organic solvents like methanol, chloroform, etc. Apramycin Sulfate Aqueous solution is very stable. Not dangerous at all.

Assay:  Potency not less than 550ug/mg. counted on Apramycin Sulfate API, Raw Material

Formula:   C21H41N5O11,2½H2SO4    784.8 

Apramycin Sulfate or Apramycin Sulphate API, Raw Material formula.gif

Package: 10Bou(Billion unit)/Aluminium Tin/Drum


Description:

Apramycin Sulfate is a broad spectrum bactericidal aminoglycoside. It is effective on gram -ve and gram +ve bacteria. Apramycin Sulfate belongs to aminocyclitol group. It can be produced by the actinomycete Streptomyces tenebrarius.  Apramycin Sulfate is highly soluble in water, slightly soluble in the lower alcohols and essentially insoluble otherwise.

Apramycin Sulfate raw material, API is a structurally unique antibiotic. With the chemical name (2R,3R,4S,5S,6S)-2-{[(2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)- octahydropyrano[3,2-b]pyran-2-yl]oxy}-5-amino-6-(hydroxymethyl)oxane-3,4-diol, it contains a bicyclic sugar moiety and a monosubstituted deoxystreptamine.

 Apramycin Sulfate API, raw material stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its property to bind to the eukaryotic decoding site despite differences in key residues required for Apramycin Sulfate recognition by the bacterial target. Apramycin Sulfate API, raw material binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of Apramycin Sulfate in eukaryotes and bacteria.

 

Indications of Apramycin Sulfate:

Apramycin Sulphate is used for the treatment of bacillary dysentery in calves E. Coli Air sac disease in Poultry.

 

As a professional China Apramycin Sulfate Salt Powder supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Apramycin Sulfate Power raw material from China for almost 10 years.

 

Apramycin Sulfate mechanism of Action:

Apramycin Sulphate salt blocks translocation. By this way it  inhibits protein synthesis. Apramycin Sulfate can also bind to the eukaryotic decoding site. When given low concentrations, Apramycin Sulfate is more effectively than kanamycin A, streptomycin, amikacin or gentamicin. Apramycin Sulfate will inhibit elongation and will also induce mRNA misreading during protein synthesis time.

 

Apramycin Sulfate mode of action

Apramycin Sulfate acts against bacteria by exerting marked inhibitory effects on protein synthesis at the ribosome level. 

 

Side effects of Apramycin Sulfate:

Long time usage will build drug resistance. 


Usage: Apramycin Sulfate (Apramycin Sulphate) is an aminoglycoside antibiotic. It is a new generation of veterinary drug. It is approved by Agriculture Ministry of People’s republic of China.

Apramycin Sulfate (Apramycin Sulphate) is working against G-Bacterium in veterinary industry. It is good antibiotic. There won’t be a drug resistance for Apramycin Sulfate. The application is for the infections of animals.

Storage Conditions:  Protected form direct sun. Airtight container.

 

Warnings and Notes:

Treated animals must not be slaughtered for use in food for at least 28 days after the latest treatment with this drug.


COA of Apramycin Sulfate

Testing   Item

Standard

Result

Appearance

Apramycin   Sulfate

Yellowish or yellowish-brown powder

Yellowish Powder

Identification

Apramycin   Sulfate

Should   comply.

Complies

Melting Point

152°C ~ 156°C

155.0°C ~ 155.5°C

Individual   Impurity

≤ 14.0%

6.4%

Any other impurity

≤ 4.0%

2.4%

Total impurities

≤ 30.0%

15.4%

Loss on drying

≤ 10%

7.3%

Residual   on Ignition

≤ 1.0%

0.3%

Heavy Metal

≤ 20ppm

< 20ppm

Assay

Apramycin   Sulfate

≥ 550units/mg (Dried)

Dried:   594units/mg

Non-Dried:   548units/mg


Top Quality, Pure Apramycin Sulfate (Apramycin Sulphate) Powder;  Apramycin Sulfate (Apramycin Sulphate) Raw Material Suppliers in China. Apramycin Sulfate (Apramycin Sulphate) API Manufacturers. 


If you are looking for the Apramycin Sulfate or Apramycin Sulphate API, Raw Material CAS 41194-16-5, welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.

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