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Cefoperazone Sodium Salt Powder BP, EP, USP (Sterile) CAS 62893-20-3

Cefoperazone Sodium Salt Powder BP, EP, USP (Sterile) CAS 62893-20-3

Cefoperazone Sodium Salt Powder BP, EP, USP (Sterile) CAS 62893-20-3 Product Name: Cefoperazone Sodium Salt Powder Synonyms: Cefoperazone-Na, Cefoperazone Monosodium;...

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Cefoperazone Sodium Salt Powder BP, EP, USP (Sterile) CAS 62893-20-3

Cefoperazone Sodium Salt Powder BP, EP, USP (Sterile).jpg

Product Name: Cefoperazone Sodium Salt Powder

Synonyms: Cefoperazone-Na, Cefoperazone Monosodium; sodium,(6R,7R)-7-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

CAS Number: 62893-20-3

Characteristics:  White to yellowish powder or crystalline powder

Assay: 870ug/mg ~ 1015ug/mg, Cefoperazone Sodium

Formula: C25H26N9NaO8S2; C25H27N9O8S2.Na

Structure:

Cefoperazone Sodium Salt Powder BP, EP, USP (Sterile) formula.jpg

KEY Words: Cefoperazone Sodium, Cefoperazone Sodium Salt, Cefoperazone Sodium Powder,

Cefoperazone Sodium USP, BP, EP Sterile

Package: 5Kgs/Aluminium Container; 2 Containers/Carton Box

Description:

Cefoperazone Sodium semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety. It is mainly used for bacterial infections, respiratory tract infections and other some related conditions or diseases. Cefoperazone Sodium has been proven to work effectively especially against Pseudomonas infections. It is resistant to beta-lactamase.

Special Notice: Use with caution in hepatic disease or biliary obstruction.

Safety and effectiveness of Cefoperazone Sodium Salt Powder for kids should check with doctors before using.

Side Effects: There is a small chance of Hypoprothrombinemia, which may result in bleeding or bruising.

Drug Interactions: If Cefoperazone Sodium is concomitantly used together with ethanol, it may cause an Antabuse-like reaction.

As a professional China Sterile Cefoperazone Sodium Salt Powder API Raw Material BP, EP, USP supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Sterile Cefoperazone Sodium Salt Powder API Raw Material BP, EP, USP from China for almost 10 years. 


Mechanism of Action:

Cefoperazone Sodium improves the patient's condition by Inhibiting the bacterial cell wall synthesis. By this way, it will kill the bacterial.

Very commonly, Cefoperazone Sodium will work together with Sulbactam Sodium. It will be a very popular intravenous injection product in our every day use.

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Cefoperazone Sodium USP, BP, EP Sterile is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefoperazone Sodium USP, BP, EP Sterile will effectively inhibit transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like this raw material. Cefoperazone Sodium USP, BP, EP Sterile has greater action against pseudomonas & has good action against salmonella typhi & B.fragilis

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Pharmacokinets of Cefoperazone Sodium

Absorption: Orally, Cefoperazone Sodium USP, BP, EP Sterile will not be well absorbed. Thus, it should be given parenterally.

Distribution: Cefoperazone Sodium USP, BP, EP Sterile is widely distributed & good CSF penetration.

Metabolism: Cefoperazone Sodium USP, BP, EP Sterile is not significantly metabolized inside the body.

Excretion: Cefoperazone Sodium USP, BP, EP Sterile will be excreted mainly through bile & a small portion is excreted in urine. A small amount is seen in breast milk.

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Cefoperazone Sodium USP, BP, EP Sterile

CAS NO. 62893-19-0 (Cefoperazone Base)

CAS NO. 62893-20-3 (Cefoperazone Sodium)

 

Cefoperazone Sodium USP, BP, EP Sterile:

Formula C25h27n9o8s2·Na

Mol wt. 667.65

Classification: antiboitics / cephalosporins /

 

Physical and chemical properties of Cefoperazone Sodium USP, BP, EP Sterile:

It is white to slightly yellowish crystalline powder

Solubility: Cefoperazone Sodium USP, BP, EP Sterile is freely soluble in water, (practically insoluble in ether)

Ph: 4.5 - 6.5

It is Stability stable under ordinary conditions.

 

General Description & Applications:

 

Cefoperazone Sodium USP, BP, EP Sterile is a broad-spectrum derived from species of fungi of the genus Cephalosporium and are related to the penicillins in both structure and mode of action but relatively penicillinase-resistant antibiotics. Cefoperazone Sodium USP, BP, EP Sterile has low toxicity for the host, considering their broad antibacterial spectrum. Cefoperazone Sodium USP, BP, EP Sterile has the active nucleus of beta-lactam ring which results in a variety of antibacterial and pharmacologic characteristics when modified mainly by substitution at 3 and 7 positions. The antibacterial activities of Cefoperazone Sodium USP, BP, EP Sterile result from the inhibition of mucopeptide synthesis in the cell wall.

Cefoperazone Sodium USP, BP, EP Sterile is widely utilized to treat gonorrhea, meningitis, pneumococcal, staphylococcal and streptococcal infections, etc.

Each newer generation of cephalosporins has broader range of activity against gram-negative organisms but a narrower range of activity against gram-positive organisms than the preceding generation. Accordingly, Cefoperazone Sodium USP, BP, EP Sterile is able to penetrate into tissues well, and thus antibiotic levels are good in various body fluids.

 

Cefoperazone Sodium USP, BP, EP Sterile is a semi-synthetic 3rd generation cephalosporin effective against a wide range of aerobic and anaerobic gram-positive and gram-negative bacteria. Cefoperazone Sodium USP, BP, EP Sterile is a white to pale yellow crystalline powder; soluble in water, methanol; slightly soluble in dehydrated alcohol; insoluble in acetone, ethyl acetate, ether. Chemical designation is [6R-[6a,7b(R')]]-7-[[[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl] amino](4-hydroxyphenyl) acetyl]amino]-3 -[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo- 5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt.

 

Chemistry: As a third generation cephalosporin, Cefoperazone Sodium USP, BP, EP Sterile contains a piperazine side chain giving it anti-pseudomonal activity. It looks white, crystalline powder and Cefoperazone Sodium USP, BP, EP Sterile is freely soluble in water and poorly soluble in alcohol. At room temperature, it has a maximum solubility in compatible IV solutions of 475 mg/ml (at concentrations >333 mg/ml vigorous and prolonged shaking may be required). Reconstituted solutions of Cefoperazone Sodium USP, BP, EP Sterile have a pH from 4.5 - 6.5. One gram contains 1.5 mEq of sodium.

 

Storage/Stability/Compatibility:  Cefoperazone Sodium USP, BP, EP Sterile for injection should be kept at temperatures less than 25°C and protected from light. Once reconstituted, solutions do not need to be protected from light.

 

 Uses and Indications: Cefoperazone Sodium USP, BP, EP Sterile is applied to treat serious infections, particularly against susceptible Enterobacteriaceae not susceptible to other less expensive agents or when aminoglycosides are not indicated (due to their potential toxicity).

 

Adverse Effects & Warnings: Cefoperazone Sodium USP, BP, EP Sterile is a relatively safe agent. Rarely, hypersensitivity reactions can potentially happen in animals. Because of its thiomethyltetrazole side-chain,  Cefoperazone Sodium USP, BP, EP Sterile may also rarely cause hypoprothrombinemia. However, side effects like Diarrhea secondary to changes in gut flora have been detected. .

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Properties of Cefoperazone Sodium USP, BP, EP Sterile:

EINECS: 263-751-5

CAS No.: 62893-20-3

Cefoperazone Sodium USP, BP, EP Sterile Melting Point: 200-202 °C

Formula: C25H27N9O8S2.Na

Cefoperazone Sodium USP, BP, EP Sterile solubility H2O: 50 mg/mL, clear, faintly yellow

Water Solubility Soluble in water. Slightly soluble in alcohol.

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COA of Cefoperazone Sodium

Testing Item

Standard

Result

Appearance
 Cefoperazone    Sodium

White    to yellowish powder or crystalline powder

White powder

Identification
 Cefoperazone    Sodium

Should comply.

Complies

pH

4.5    ~ 6.5

5.33

Absorbance

≤    0.15 (430nm)

0.04 (430nm)

Particulate Matters
 ≥    10um

≤    6000particles/g

86.4 particles/g

Particulate Matters
 ≥25um

≤    600particles/g

14.3 particles/g

Visible foreign matters

Essentially free from

Absent

Impurity A

≤    3.0%

0.08%

Cefoperazone
 (Impurity C)

≤    0.4%

0.08%

Other    Single Impurity

≤    2.0%

0.006%

Other    Total Impurity

≤    3.0%

0.17%

Cefoperazone    Polymer

≤    0.4%

0.13%

Acetone

≤    2.0%

0.86%

Methanol

≤    0.3%

Undetectable

Ethanol

≤    0.5%

0.002%

Isopropanol

≤    0.5%

Undetectable

Butyl    Alcohol

≤    0.5%

Undetectable

Propanol

≤    0.5%

Undetectable

Acetic    Ether

≤    0.5%

Undetectable

Methyl    Isobutyl Ketone

≤    0.5%

Undetectable

Cyclohexane

≤    0.388%

Undetectable

Diethylene    Oxide

≤    0.072%

Undetectable

Dichloromethane

≤    0.06%

0.0004%

Acetonitrile

≤    0.041%

Undetectable

N,N-Diethylacetamide

≤    0.109%

Undetectable

Water

≤    4.0%

3.54%

Heavy    Metal

≤    10ppm

<    10ppm

Bacterial    Endotoxin

≤    0.025Eu/mg

< 0.025Eu/mg

Sterility

Sterile    Cefoperazone Sodium

Sterile

Assay
 Cefoperazone    Sodium

870ug/mg    ~ 1015ug/mg
 Anhydrous    Basis

936.9ug/mg

Our product conforms to the standard of USP39

Other Names:

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2R)-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt, (6R,7R)- (9CI); 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl] amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodium salt, [6R-[6a,7b(R*)]]-; Bioperazone;CP 52640-2; Cefobis; Cefogram; Cefomycin; Cefoneg; Cefoperazone sodium; Cefoperazone sodium salt; Cefosint; Dardum; Farecef; Kefazon; Myticef; Novobiocyl; Pathozone; Peracef; Sodium cefoperazone;

 

Top Quality, China Pure Cefoperazone Sodium Powder/Substance factory in China; China Cefoperazone Sodium Salt Raw Material Suppliers in China. China Cefoperazone Sodium Salt API Manufacturers in China. 


If you are looking for the cefoperazone sodium salt powder bp, ep, usp (sterile) cas 62893-20-3, welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.
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