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Procaine Benzylpenicillin Or Penicillin G Procaine CAS 54-35-3

Procaine Benzylpenicillin Or Penicillin G Procaine CAS 54-35-3

Procaine Benzylpenicillin or Penicillin G Procaine CAS 54-35-3 API Raw Material Powder Product Name: Procaine Benzylpenicillin or Penicillin G Procaine Synonyms: Procaine Benzylpenicillin, Penicillin G Procaine, Benzylpenicillin procaine, Procaine Penicillin G, Novocaine Benzylpenicillin, Penicillin G Novocaine CAS...

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Procaine Benzylpenicillin or Penicillin G Procaine CAS 54-35-3

Procaine Benzylpenicillin Or Penicillin G Procaine.png


Product Name: Procaine Benzylpenicillin or Penicillin G Procaine

Synonyms: Procaine Benzylpenicillin, Penicillin G Procaine, Benzylpenicillin procaine, Procaine Penicillin G,  Novocaine Benzylpenicillin, Penicillin G Novocaine

CAS Number: 54-35-3

Characteristics: White or almost white crystalline powder

Assay:  96.0% ~ 102.0% Procaine Benzylpenicillin, Penicillin G Procaine

Formula:  C29H38N4O6S

Structure Formula: 

Procaine Benzylpenicillin Or Penicillin G Procaine formula.png

Package information: 20BOU/Drum
KEY Words: Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine, Penicillin G Novocaine API Raw Material Powder

Chemical Name: 2-diethylaminoethyl 4-aminobenzoate (6R)-(2-phenylacetamido) penicillinate monohydrate

Description:
Procaine Benzylpenicillin or Penicillin G Procainea combination of Penicillin G and Procaine.
Penicillin G is an antibiotic. That is why Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Some gram-negative organisms such as Neiserria gonorrhoeae and Neiserria meningitidis are also reported to be susceptible to penicillin G.
Penicillin G is also known as benzylpenicillin. Procaine is also known as Novacaine.
Benzylpenicillin contains a 6′ phenylacetyl side chain. In acid aqueous solutions, penicillin is reported to decompose into penillic acid and penilloic acid.
Procaine or Novocaine is a noted sodium channel blocker with a variety of inhibitory effects.
In skeletal muscle, procaine (Novocaine) has been reported to inhibit calcium-induced calcium release. Procaine is also noted to act as a DNA methylation inhibitor and it will cause demethylation and reactivation of methylation-silenced genes.
Procaine or novocaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound.
Procaine benzylpenicillin , also known as Procaine Penicillin G, is an antibiotic useful for the treatment of a number of bacterial infections. It is a form of penicillin which is a combination of benzylpenicillin and the local anaesthetic agent procaine. Following deep intramuscular injection, it is slowly absorbed into the circulation and hydrolysed to benzylpenicillin -- thus it is used where prolonged low concentrations of benzylpenicillin are required. This combination is aimed at reducing the pain and discomfort associated with a large intramuscular injection of penicillin. It is widely used in veterinary settings.

Usage:
Procaine Benzylpenicillin also know as Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine, Penicillin G Novocaine. It has both the function of Procaine and Penicillin. They work together.
Procaine Benzylpenicillin is a widely used substance in pharmaceutical area.


As a professional China Penicillin G Procaine, Procaine Penicillin G Raw Material supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Procaine Benzylpenicillin, Benzylpenicillin Procaine, Penicillin G Novocaine API from China in China for almost 10 years.

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Procaine benzylpenicillin also known as penicillin G procaine, Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine, Penicillin G Novocaine, is an antibiotic which will help the treatment of a lot of bacterial infections. Specifically, Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G API Raw Material Powder is widely indicated for syphilis, anthrax, mouth infections, pneumonia, diphtheria, cellulitis, and animal bites. Benzylpenicillin Procaine, Penicillin G Novocaine is given by injection into a muscle.

 

However, there can be Side effects include pain at the site of injection, blood clotting problems, seizures, and allergic reactions including anaphylaxis, etc. Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G is also popularly utilized to treat syphilis. It is not recommended for the people who have a history of penicillin allergy or procaine allergy. Usage of Benzylpenicillin Procaine, Penicillin G Novocaine during pregnancy and breastfeeding is relatively safe. Procaine benzylpenicillin is in the penicillin and beta lactam family of medications. Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G acts via benzylpenicillin and will kill the bacterial. Procaine makes the combination long acting.[3]

In the year 1948,  Benzylpenicillin Procaine, Penicillin G Novocaine was firstly introduced for pharmaceutical use. It is the most effective and safe medicines needed in a health system.

 

Medical uses:

Specific indications for Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G are as following:

-Syphilis

In the United States, Bicillin C-R (a injectable suspension which 1.2 million units of benzathine penicillin and 1.2 million units of procaine penicillin per 4 ml) is not recommended for treating syphilis, because it contains only 50% the suggested dose of Benzylpenicillin Procaine, Penicillin G Novocaine. Medication errors have been made due to the confusion between Bicillin L-A & Bicillin C-R. As a result, changes in product packaging have been made; specifically, the statement "Not for the Treatment of Syphilis" has been added in red text to both the Bicillin CR and Billin CR 900/300 syringe labels.

-Together with Erythromycin, Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G is used to treat strep throat, given as one IM injection

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Benzylpenicillin Procaine, Penicillin G Novocaine is also used as an adjunct in the treatment of anthrax.

 

Adverse effects of Benzylpenicillin Procaine, Penicillin G Novocaine:

At high doses, procaine penicillin might cause seizures and CNS abnormalities due to the procaine present in it.

 

Mechanism of action of Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G:

This product is a form of penicillin which is a combination of benzylpenicillin and the local anaesthetic agent procaine. Following deep intramuscular injection, Benzylpenicillin Procaine, Penicillin G Novocaine will be absorbed into the circulation slowly and hydrolysed to benzylpenicillin. Therefore, Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G is used where prolonged low concentrations of benzylpenicillin are needed in the treatment.

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Main indexes of Penicillin G Novocaine (Penicillin G Procaine)


     Testing Item

Standard

Result

Appearance
Penicillin G Novocaine

White or almost white crystalline powder

Complies

Identification
Penicillin G Procaine

IR spectrum complies with that of reference standard (IR)

Complies

pH (50mg/15ml H2O)

5.0 ~ 7.5

5.9

Specific Optical Rotation

+165°  ~ +180°

+172°

Moisture

2.8% ~ 4.2%

3.1%

Related Substances

Impurity A: Not more than the area of the corresponding peak in the chromatogram obtained with reference solution(c) ≤  0.024%

4-aminobenzoic acid:
     0.003%

Any other impurity (B, C, D, E): for each impurity not more than the area of the peak due to benzylpenicillin in the chromatogram obtained with the reference solution(c) ≤  1%

Not detected

Residual Solvents(GC)

n-Butanol ≤  5000ppm

89ppm

Ethyl acetate ≤  5000ppm

8ppm

Bacterial Endotoxins

< 0.10IU/mg

< 0.10IU/mg

Procaine (HPLC)

39.0% ~ 42.0%

40.9%

Procaine Benzylpenicilln
(Penicillin G Novocaine)

96.0% ~ 102.0%

99.4%

Sterility

Should comply

Complies

This product complies with both BP and EP standard.

Top Quality, China Pure Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine Powder/Substance factory in China; China Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine Raw Material Suppliers in China. China Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine API Manufacturers in China. 

If you are looking for the procaine benzylpenicillin or penicillin g procaine cas 54-35-3, welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.
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