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Lidocaine CAS 137-58-6 and Lidocaine Hydrochloride Monohydrate or Lidocaine HCL CAS 6108-05-0

Lidocaine CAS 137-58-6 and Lidocaine Hydrochloride Monohydrate or Lidocaine HCL CAS 6108-05-0

Lidocaine CAS 137-58-6 and Lidocaine Hydrochloride Monohydrate or Lidocaine Hcl CAS 6108-05-0 RS of Lidocaine Usage: It is the raw material to make Lidocaine and Lidocaine Hcl preparations. For example: Lidocaine Topical Aerosol, Lidocaine Hydrochloride Injection, Lidocaine Hcl Jelly, Lidocaine...

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Lidocaine CAS 137-58-6 and Lidocaine Hydrochloride Monohydrate or Lidocaine Hcl CAS 6108-05-0                                              Lidocaine Hydrochloride Monohydrate or Lidocaine HCL picture.jpg

Product   Name:

Lidocaine

Lidocaine   Hydrochloride Monohydrate

Synonyms:

Lidocainum,   Lidocaine Base

Lidocaine   Hcl,

 Lidocaini hydrochloridum

Characteristics:

White   to almost white crystalline powder.

White   crystalline powder.

Solubility:  

Very   soluble in alcohol and in methylene chloride. Practically

insoluble   in water.

Freely   soluble in alcohol. Very soluble in water.

CAS   Number:

37-58-6

6108-05-0

Assay:

97.5%   ~ 102.5%

99%   ~ 101%

Standard:

BP,   EP, USP

BP,   EP, USP

Formula:

C14H22N2O

C14H23ClN2O,H2O

Structure:  

Lidocaine base formula.gif

Lidocaine Hydrochloride Monohydrate or Lidocaine HCL formula.jpg

Package:

25Kg/Cardboard   Drum

25Kg/Cardboard   Drum

Description:

Lidocaine is a local anesthetic and cardiac depressant. It is usually used as an antiarrhythmia substance. The actions of Lidocaine Hydrochloride are more intense and effects of Lidocaine Hcl are more prolonged than those of procaine. While duration of action of Lidocaine Hydrochloride is shorter than that of bupivacaine or prilocaine.

 

Lidocaine and Lidocaine Hydrochloride are widely used in the production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.

 

The mechanism of action of the anti-arrhythmic effect of Lidocaine seems to be similar as procaine, procainamide and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected. In contrast to the latter 3 similar medicines, Lidocaine has advantage in therapeutic doses, it does not produce a significant decrease in arterial pressure or in cardiac contractile force. In larger doses, Lidocaine Hydrochloride can induce circulatory depression, but the magnitude of the change is less than that found with comparable doses of procainamide.

 

As a professional China Lidocaine Hydrochloride, Lidocaine Hcl  raw material supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Lidocaine Hydrochloride, Lidocaine Hcl  raw material from China for almost 10 years.

 

Mechanism of Action:

Lidocaine Hydrochloride stabilizes the neuronal membrane. It inhibits the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. Lidocaine alters signal conduction in neurons by blocking the fast voltage gated sodium channels in the neuronal cell membrane that are responsible for signal propagation. With sufficient blockage the membrane of the postsynaptic neuron will not depolarize and will thus fail to transmit an action potential. This creates the anaesthetic effect by not merely preventing pain signals from propagating to the brain but by aborting their birth in the first place.


RS of Lidocaine

RS of Lidocaine Hydrochloride.jpg 

Usage:  It is the raw material to make Lidocaine and Lidocaine Hcl preparations.

For example: Lidocaine Topical Aerosol, Lidocaine Hydrochloride Injection, Lidocaine Hcl Jelly, Lidocaine Hydrochloride Oral Topical Solution.

And together with other APIs, there are Neomycin and Polymyxin B Sulfates and Lidocaine Cream.  Lidocaine and Lidocaine Hcl is mainly used to make us fell no pain. 

Certificate of Analysis: Lidocaine Base

Tests

Specifications

Results

Characters

Lidocaine Base

White   or slightly yellow crystalline powder with characteristic odor.

Conforms

Identification (Lidocaine)

Should comply

Complies

Appearance   of solution

Clear   and colorless

Complies

Moisture

≤0.5%

0.32%

Sulphate

≤0.1%

0.058%

Chloride

≤0.0035%

≤0.0025%

Heavy   metals

≤20ppm

10ppm

Residue   on ignition

≤0.1%

0.01%

Impurity

(2,   6-dimethylaniline content)

≤0.01%

Complies

Assay(HLPC)

99.0%~101.0% (Lidocaine)

99.8%

Conclusion:

The   product meets the specification of BP2010 Standard.

 

Certificate of Analysis: Lidocaine Hydrochloride(Hcl)

Tests

Specifications

Results

Characters

Lidocaine Hcl

White   crystalline powder

Conforms

Melting   Point

74~79

75~76.5

Identification (Lidocaine Hydrochloride)

Should comply

Complies

Appearance   of solution

Clear   and colorless

Complies

Moisture

5.5~7.0%

6.44%

Impurity

(2,   6-dimethylaniline content)

Should   Comply

Complies

Sulphated   Ash

≤0.1%

0.02%

Heavy   metals

≤5ppm

<5ppm

PH

4.0~5.5

4.6

Assay (Lidocaine Hydrochloride)

99.0%~101.0% (Lidocaine Hcl)

100%

Conclusion:

The   Product meets the specification of BP2010.


 Top Quality, Pure Lidocaine Powder;  Lidocaine Hydrochloride Raw Material Supplier in China. Lidocaine Hydrochloride API Manufacturer. 


Related products you may interested:

1.Benzocaine CAS 94-09-7 and Benzocaine Hydrochloride or Benzocaine HCL CAS 23239-88-5

2.Procaine CAS 59-46-1 and Procaine Hydrochloride or Procaine HCL CAS 51-05-8

3.Lidocaine CAS 137-58-6 and Lidocaine Hydrochloride Monohydrate or Lidocaine HCL CAS 6108-05-0


If you are looking for the lidocaine cas 137-58-6 and lidocaine hydrochloride monohydrate or lidocaine hcl cas 6108-05-0, welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.

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Add: Room 1101, 5th Building, No.168 Shenzhen Road, Qingdao, China
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