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Prazosin Hydrochloride or Prazosin Hcl Powder API Raw Material CAS 19237-84-4

Prazosin Hydrochloride or Prazosin Hcl Powder API Raw Material CAS 19237-84-4

Prazosin Hydrochloride or Prazosin Hcl Powder API Raw Material CAS 19237-84-4 Product Name: Prazosin Hydrochloride Synonyms: Prazosin Hcl Chemical name: 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-piperazine * HCl CAS Number: 19237-84-4 Characteristics: White to almost white powder Assay: 97.0% ~...

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Prazosin Hydrochloride or Prazosin Hcl CAS 19237-84-4

Prazosin Hydrochloride or Prazosin Hcl Powder API Raw Material.png


Product Name: Prazosin Hydrochloride

Synonyms: Prazosin Hcl

Chemical name: 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-piperazine * HCl

CAS Number: 19237-84-4

Characteristics: White to almost white powder

Assay: 97.0% ~ 103.0% Prazosin Hydrochloride

Formula:  C19H22ClN5O4; C19H21N5O4•HCl   

Structure Formula:

Prazosin Hydrochloride or Prazosin Hcl Powder API Raw Material formula.png

KEY Words: Prazosin Hydrochloride, Prazosin Hcl, Prazosin Powder API, Raw Material

Package: 25Kg/Fiber DrumCardboard DrumPaper Drum

Prazosin Hydrochloride or Prazosin Hcl Powder API Raw Material structure.png

Description:
Prazosin Hydrochloride is the hydrochloride salt of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl) piperazine. Prazosin Hydrochloride is a selective adrenergic alpha-1 antagonist. It is a quinazoline derivativeand the first of a new chemical class of antihypertensives. Prazosin Hcl is used to fight against heart failure, hypertension, pheochromocytoma, etc.
Prazosin Hydrochloride is a synthetic piperazine derivative. It has hypotensive antiadrenergic ability. Prazosin Hcl reduces peripheral resistance and relaxes vascular smooth muscles. The exact mechanism is not completely known.

Prazosin Hydrochloride causes a decrease in total peripheral resistance. It was originally believed to have a direct relaxant action on vascular smooth muscle. But recent animal studies have suggested that the vasodilator effect of Prazosin Hcl is also related to blockade of postsynaptic alpha-adrenoceptors. The results of experiments demonstrate that the peripheral vasodilator effect of Prazosin Hydrocloride is confined mainly to the level of the resistance vessels. Not like the conventional alpha-blockers, the antihypertensive action of Prazosin Hcl is usually not accompanied by a reflex tachycardia. Tolerance has not been observed to develop in long term therapy.

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Prazosin hydrochloride API Raw Material BP, EP, USP is a quinazoline derivative, which is the first of a new chemical class of anti-hypertensives. It is the hydrochloride salt of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl) piperazine.

Molecular formula is C19H21N5O4 • HCl

 

Prazosin hydrochloride or Prazosin Hcl API Raw Material BP, EP, USP is a white to tan powder. It is slightly soluble in water and methanol, very slightly soluble in alcohol, practically insoluble in chloroform and acetone and has a molecular weight of 419.87.

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As a professional China Clotrimazole Raw Material supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Clotrimazole API from China in China for almost 10 years.

 

Method of preparation:

Prazosin hydrochloride or Prazosin Hcl API Raw Material BP, EP, USP is synthetically prepared.

Methods of analysis including, Thin-Layer chromatography. 

 

Stability / storage as supplied:

Prazosin hydrochloride or Prazosin Hcl API Raw Material BP, EP, USP is stable for at least 24 months when stored desiccated at room temperature and protected from the light.

 

Usage / applications:

Prazosin hydrochloride or Prazosin Hcl API Raw Material BP, EP, USP suppresses the clinical and histological expression of experimental autoimmunue.

encephalomyelitis (EAE) in the Lewis rat supporting the idea that antagonists of adrenergic receptors can modulate the expression of this disease in the Lewis rat.

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Property of

Name: Prazosin hydrochloride

EINECS: 242-903-4

Prazosin Hcl CAS No.: 19237-84-4

Solubility: water:1 mg/mL, clear, colorless

Prazosin Hcl Melting Point: 277 - 280 °C

Formula: C19H21N5O4.HCl

Prazosin Hydrochloride Boiling Point: 638.4 °C at 760 mmHg

Molecular Weight: 419.87

Flash Point: 339.9 °C

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Other Names:

Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-,monohydrochloride (9CI); 2-[4-(2-Furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazolinehydrochloride; Adversuten; Adverszuten; Alpress LP; CP 12299-1; Deprazolin; Duramipress; Hypovase; Hypovasole; Minipress; NSC 292810; Pratsiol; Sinetens

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Certificate of Analysis (Prazosin Hydrochloride)

Testing Item

Standard

Result

Appearance
Prazosin Hcl

White to almost white powder

Complies

Identification
Prazosin Hydrochloride

Should comply (USP35).

Complies

Moisture

≤ 2.0%

0.4%

Residual on Ignition

≤ 0.4%

0.07%

Heavy Metal

≤ 0.005%

<0.005%

Iron

≤ 0.010%

<0.010%

Nickel

≤ 0.010%

<0.010%

Ordinary Impurity (TLC)

≤ 2.0% 

<2.0%

Assay
Prazosin Hydrochloride

97.0% ~ 103.0%
Prazosin Hcl

99.4%

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Prazosin Hydrochloride Or Prazosin Hcl Powder API Raw Material CAS 19237-84-4

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