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Diphenhydramine Hcl or Diphenhydramine Hydrochloride Powder API, Raw Material CAS 147-24-0

Diphenhydramine Hcl or Diphenhydramine Hydrochloride Powder API, Raw Material CAS 147-24-0

Diphenhydramine Hcl or Diphenhydramine Hydrochloride Powder API, Raw Material CAS 147-24-0 Product Name: Diphenhydramine Hcl or Diphenhydramine Hydrochloride Synonyms: 2-(Benzhydryloxy)-N,N-dimethylethylamine Hydrochloride; Diphenhydramin Hcl or Diphenhydramin Hydrochloride CAS Number: 147-24-0 Characteristics: White or...

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Diphenhydramine Hcl or Diphenhydramine Hydrochloride CAS 147-24-0

Diphenhydramine Hcl or Diphenhydramine Hydrochloride Powder API, Raw Material .png


Product Name: Diphenhydramine Hcl or Diphenhydramine Hydrochloride Powder API, Raw Material CAS 147-24-0

Synonyms: 2-(Benzhydryloxy)-N,N-dimethylethylamine Hydrochloride; Diphenhydramin Hcl or Diphenhydramin Hydrochloride

CAS Number: 147-24-0

Characteristics: White or almost white crystalline powder.

Assay:  99.0% ~ 101.0% Diphenhydramine Hcl

Formula:   C17H22ClNO; C17H21NO•HCl

Structure Formula: 

Diphenhydramine Hcl or Diphenhydramine Hydrochloride Powder API, Raw Material formula.png

Package information: 25Kg/Fiber DrumCardboard DrumPaper Drum
KEY Words: Diphenhydramine Hcl, Diphenhydramine Hydrochloride Powder API, Raw Material

Description: 

Diphenhydramine Hydrochloride is a first-generation antihistamine with the properties of  anti-cholinergic, anti-tussive,anti-emetic, and sedative. It can also be used to fight against allergies. Diphenhydramine Hcl raw material has a strong hypnotic effect and it is a FDA-approved drug used as a nonprescription sleep aid.

 Uses of Diphenhydramine Hydrochloride:

This substance is able to eliminate almost all kinds of allergy symptoms. Further more, Diphenhydramine Hcl API has a calming, anti-motion sickness, antiemetic, and anticholinergic effects. It will also relieve bronchial smooth muscle spasm.
Diphenhydramine Hcl raw material is used for the treatment of a lot of allergic skin diseases, like urticaria, insect bites problems;

At last,  Diphenhydramine Hcl has very good effect for motion sickness, nausea or vomiting, etc.


As a professional China Diphenhydramine Hcl API supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Diphenhydramine Hcl raw material from China for almost 10 years. 


Diphenhydramine Hcl is also called Diphenhydramine Hydrochloride. It is the chloride form of Diphenhydramine.
Diphenhydramine Hcl or Diphenhydramine Hydrochloride is a H1-histamine receptor antagonist.
It works as an hypnotic, antihistaminic, antiparkinson, sedative.
Diphenhydramine Hcl or Diphenhydramine Hydrochloride prevents the actions of histamine on a lot of muscles. By this way, there can be some good effect like the following:
Avoid smooth muscle spasms, Prevents histamine-induced bronchoconstriction, vasodilation, etc.
Diphenhydramine hydrochloride is also a sodium channel blocker. This will help its actions as a local anesthetic.
Diphenhydramine hydrochloride was found to inhibit re-uptake of the neurotransmitter serotonin, which led to a search for viable antidepressants with similar structures and fewer side effects

Diphenhydramine Hcl side effects:
It has some undesired antimuscarinic and sedative effects.
NOTE: Please do not overdose Diphenhydramine Hydrochloride.

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Common side effects:

Diphenhydramine Hcl, Diphenhydramine Hydrochloride Powder API, Raw Material may lead to nausea, dry mouth, sleepiness, thickening of mucus, and anorexia (serious loss in body weight due to refusal to eat).

Less common side effects of Diphenhydramine Hcl, Diphenhydramine Hydrochloride Powder API, Raw Material BP EP USP include skin rash, blurry vision, rapid heartbeat, hypersensitivity reactions (such as to the light and sun), ringing in the ears, headache, dizziness, low blood pressure, diarrhea, painful urination, difficult urination, constipation and confusion. There are no known special problems associated with long-term use of Diphenhydramine Hcl, Diphenhydramine Hydrochloride Powder API, Raw Material BP EP USP.

 

There are no known significant increases or proof in birth defects associated with Diphenhydramine Hcl, Diphenhydramine Hydrochloride Powder API, Raw Material BP EP USP in humans. However, the safety with pregnant women has not been determined yet. Animal researches about Diphenhydramine Hcl, Diphenhydramine Hydrochloride Powder API, Raw Material BP EP USP still do not suggest that birth defects are associated with this API.

 

NOTE and Precautions:

Diphenhydramine Hcl, Diphenhydramine Hydrochloride Powder API, Raw Material BP EP USP should not be prescribed to the people who suffer from the following problems:

Suddenly occurring attacks of asthmaand hypersensitivity to this drug.

Children who are not older than 2 years and people who can not tolerate alcohol should avoid Diphenhydramine Hcl, Diphenhydramine Hydrochloride Powder API, Raw Material BP EP USP.

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Property:

Name: Diphenhydramine hydrochloride

EINECS: 205-687-2

Diphenhydramine Hcl, Diphenhydramine Hydrochloride CAS No.: 147-24-0

Density: 1.024 g/cm3

Solubility: 1000 g/L in water

Diphenhydramine Hcl, Diphenhydramine Hydrochloride Melting Point: 168-172 °C

Formula: C17H21NO.HCl

Boiling Point: 343.7 °C at 760 mmHg

Molecular Weight: 291.85

Flash Point: 101.5 °C

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Diphenhydramine Hcl, Diphenhydramine Hydrochloride Indications:

Acute allergic reactions (mild, moderate, or severe)

Anaphylaxis

Acute dystonic reactions associated with ingestion of phenothiazines and related drugs (haloperidol, thorazine, compazine, metaclopromide, ziprasidone)

 

Precautions:

In premature babies and infants, Diphenhydramine Hcl, Diphenhydramine Hydrochloride in over-dosage might lead to convulsions or even death.

It might also cause significant sedation or paradoxical excitation/akethesia

Diphenhydramine Hcl, Diphenhydramine Hydrochloride has additive effects with alcohol and other CNS depressants.

Antihistamines like Diphenhydramine Hcl, Diphenhydramine Hydrochloride,  may cause dizziness, confusion, delirium, hallucinations, and/or hypotension in the elderly (60 years or older)

Diphenhydramine Hcl, Diphenhydramine Hydrochloride Powder API, Raw Material BP EP USP has an atropine-like action. Thus, it should be used very cautiously in patients who have a history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease or hyper-tension.

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Main indexes of Diphenhydramine Hcl, Diphenhydramine Hydrochloride:


     Testing Item

Standard

Result

Appearance
Diphenhydramine Hydrochloride

White or almost white crystalline powder.

White crystalline powder.

Solubility

Very soluble in water, freely soluble in alcohol

Complies

Identification A
Diphenhydramine Hydrochloride

Melting Point: 168~172°C

168.2~169.8°C

Identification B
Diphenhydramine Hcl

A258nm/A253nm=1.1~1.3
     A258nm/A264nm=1.2~1.4

Complies
     Complies

Identification C
Diphenhydramine Hydrochloride

IR: Comply with reference.

Complies

Identification D
Diphenhydramine Hcl

The chloride reaction

Positive

Appearance of solution

Clear, ≤BY6

Complies

Acidity or alkalinity

≤ 0.5ml of 0.01M NaOH

Complies

Loss on drying

≤ 0.5%

0.14%

Impurity A

≤ 0.5%

Not detected

Any other impurity

≤ 0.3%

Not detected

Total impurities

≤ 1.0%

Not detected

Sulphated Ash

≤ 0.1%

0.08%

Assay (Dry Basis)
Diphenhydramine Hydrochloride

99.0% ~ 101.0%

100.2%

Top Quality, China Pure Diphenhydramine Hcl, Diphenhydramine Hydrochloride Powder/Substance factory in China;  China Diphenhydramine Hcl, Diphenhydramine Hydrochloride Raw Material Suppliers in China. China Diphenhydramine Hcl, Diphenhydramine Hydrochloride API Manufacturers in China. 


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Diphenhydramine Hcl Or Diphenhydramine Hydrochloride Powder API, Raw Material CAS 147-24-0

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