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Valsartan Powder Raw Material, API BP EP USP CAS 137862-53-4

Valsartan Powder Raw Material, API BP EP USP CAS 137862-53-4

China Valsartan Suppliers, China Valsartan Manufacturers CAS 137862-53-4 Product Name: Valsartan Powder Raw Material, API BP EP USP CAS 137862-53-4 Synonyms: 3,5-Diiodo-4-Pyridone N-(1-Oxopentyl)-N-{[2'-(1H-tetrazol-5-yl-1,1'-biphenyl)-4-yl]methyl}-L-valine CAS Number: 137862-53-4 Characteristics: White or off-white powder, odorless,...

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China Valsartan Suppliers, China Valsartan Manufacturers CAS 137862-53-4

Valsartan Powder Raw Material, API BP EP USP.png


Product Name: Valsartan Powder Raw Material, API BP EP USP CAS 137862-53-4

Synonyms: 3,5-Diiodo-4-Pyridone N-(1-Oxopentyl)-N-{[2'-(1H-tetrazol-5-yl-1,1'-biphenyl)-4-yl]methyl}-L-valine

CAS Number: 137862-53-4

Characteristics: White or off-white powder, odorless, slightly hygroscopy

Assay:  98.0% ~ 102.0% Valsartan

Formula:  C24H29N5O3

Structure Formula: 

Valsartan Powder Raw Material, API BP EP USP formula.png

Package information: 20KG/Fiber DrumCardboard DrumPaper Drum

KEY Words: Valsartan Powder Raw Material, API BP EP USP CAS 137862-53-4

Description:
Valsartan is a tetrazole derivative  and a nonpeptide AT1 (angiotensin II AT1-receptor) antagonist. This will cause blood vessel dilation. Valsartan is used to treat hypertension.
Valsartan selectively and competitively blocks the binding of angiotensin II to the AT1 subtype receptor in vascular smooth muscle and the adrenal gland. It prevents AT II-mediated vasoconstriction, and renal reabsorption of sodium, aldosterone synthesis and secretion,  and resulting in vasodilation, increased excretion of sodium and water, a reduction in blood pressure, and a reduction in plasma volume.

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Valsartan Powder Raw Material, API BP EP USP comes only as a tablet taken orally by mouth.

Valsartan is used to treat heart failure, lower the blood pressure, or increase the survival rate after a heart attack.

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Why is Valsartan Powder Raw Material, API BP EP USP prescribed?

Valsartan can be utilized alone or in conjunction with other drugs to treat high blood pressure. What’s more, it is applied to treat heart failure (condition in which the heart is unable to pump enough blood to the rest of the body) and to improve survival rate after a heart attack, too. Valsartan Powder Raw Material, API BP EP USP is belongs to medicines which are called angiotensin II receptor antagonists. It functions by blocking the action of certain natural chemicals that tighten the blood vessels, making the blood to flow more efficiently and the heart to pump more powerfully.

 

High blood pressure is a common condition. If not properly treated, it will lead to damage to the heart, brain, blood vessels, kidneys and some other parts of the body. Damage done to these organs might lead to heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and many other serious disorders. In addition to taking Valsartan Powder Raw Material, API BP EP USP containing drugs, making proper lifestyle changes can contribute to control the blood pressure, too. These changes include eating a diet which is low in fat and salt, maintaining a healthy weight, exercising more than half an hour per day, quit smoking, and stop alcohol in moderation.

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The mechanism of action of valsartan:
Valsartan as an Angiotensin 2 Receptor Antagonist.

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Valsartan Powder Raw Material, API BP EP USP is an oral medication that is used to treat high blood pressure and congestive heart failure. It belongs to a class of drugs called angiotensin receptor blockers (ARBs) which also includes irbesartan, losartan, and candesartan. Angiotensin, formed in the blood by the action of angiotensin converting enzyme (ACE), is a powerful substance which attaches to angiotensin receptors found in many tissues but primarily on smooth muscle cells of blood vessels. Angiotensin's attachment to the receptors will narrower the blood vessels which causes an increase in blood pressure (Technically called hypertension). Valsartan Powder Raw Material, API BP EP USP will block the angiotensin receptor. By blocking the action of angiotensin, Valsartan Powder Raw Material, API BP EP USP dilates blood vessels and reduces blood pressure.

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As a professional China Valsartan Powder Raw Material, API BP EP USP supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Valsartan Powder Raw Material, API BP EP USP from China in China for almost 10 years.

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Pregnancy or breastfeeding period:

When Valsartan Powder Raw Material, API BP EP USP is used in the 2nd or 3rd trimester of pregnancy , it might lead to injury and even death to the fetus. So, Valsartan should not be used during pregnancy. When pregnancy is detected, valsartan containing medicines should be stopped immediately.

Till now, It is still unknown if Valsartan Powder Raw Material, API BP EP USP is secreted into human milk. According to the research and studies of animals, Valsartan can be secreted into the milk of rats.

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Main indexes of Valsartan:


     Testing Item

Standard

Result

Appearance
Valsartan

White or off-white powder, odorless, slightly hygroscopy

Complies

Solubility

Comply with Valsartan Solubility

Complies

Identification
Valsartan

IR, HPLC must conforms to the reference standard

Complies

Absorbance at 420nm

≤  0.02%

< 0.02%

Water (KF)

≤  2.0%

< 0.5%

Residual on Ignition

≤  0.1%

0.05%

Heavy Metal

≤  20ppm

< 20ppm

Loss on drying

≤  0.5%

0.19%

Related Compounds

Compound A ≤  1.0%

0.38%

Compound B ≤  0.2%

0.03%

Compound C ≤  0.1%

Not Detected

Any other single impurity ≤  0.1%

0.02%

Total Impurity ≤  0.3% 

0.14%

Residual Sovents

Ethyl Acetate ≤  5000ppm

1802ppm

Hexanes ≤  290ppm

Not Detected

Methylenechloride ≤  600ppm

Not Detected

Diisopropylether ≤  500ppm

Not Detected

Assay -- Valsartan

98.0% ~ 102.0% Valsartan

100.4%

Top Quality, China Pure Valsartan Powder/Substance factory in China; China Valsartan Raw Material Suppliers in China. China Valsartan API Manufacturers in China. 


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Valsartan Powder Raw Material, API BP EP USP CAS 137862-53-4

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