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Clozapine Powder API, Raw Material CAS 5786-21-0

Clozapine Powder API, Raw Material CAS 5786-21-0

China Clozapine Suppliers, China Clozapine Manufacturers CAS 5786-21-0 Product Name: Clozapine Powder API, Raw Material CAS 5786-21-0 Synonyms: Clozapin, Clozapinum CAS Number: 5786-21-0 Characteristics: Yellow crystalline powder Assay: 98.0~102.0% Clozapine Formula: C18H19ClN4 Structure Formula: Package information: 25kg/drum KEY...

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China Clozapine Suppliers, China Clozapine Manufacturers CAS 5786-21-0


Clozapine Powder API, Raw Material.png


Product Name: Clozapine Powder API, Raw Material

Synonyms: Clozapin, Clozapinum, Clozaril

CAS Number: 5786-21-0

Characteristics: Yellow crystalline powder

Assay:  98.0~102.0% Clozapine

Formula: C18H19ClN4

Structure Formula: 

Clozapine Powder API, Raw Material formula.png

Package information:  25Kg/Fiber DrumCardboard DrumPaper Drum
KEY Words: Clozapine Powder Raw Material, APIStandard: BP, USP

Description and Usage:
Clozapine is a tricylic dibenzodiazepine. It is classified as an atypical antipsychotic substance. Clozapine binds several types of central nervous system receptors. It displays a unique pharmacological profile.
Unlike traditional anti-psychotic agents, Clozapine weakly blocks dopamine type 2 receptors and it will relieve schizophrenic symptoms (hallucinations, delusions, dementia).

Clozapine is the generic form of the brand-name drug Clozaril, which is used to treat symptoms of schizophrenia. Schizophrenia is a mental disease which will disturb our thinking, unusual emotions, and hallucinations. Clozapine has proven to be quite useful in the treatment of schizophrenia. It does tend to cause serious side effects if used improperly. Be sure to know the third-line treatment regimen to improve mood the right and safe way.

Clozapine powder Raw Material, API is in a class of drugs known as atypical antipsychotics. It is used to treat schizophrenia or reduce the risk of suicidal behavior in people with schizophrenia or other mental health disorders. Clozapine can also be utilized used in the treatment of psychosis in people who have Parkinson’s disease. It is particularly useful for people who already tried other treatment but failed. Clozapine powder Raw Material, API has been used for successfully treating other related conditions as well.

In schizophrenia, a very important substance, dopamine, is overactive. Clozapine will help to block dopamine functions in certain parts of our brain. Clozapine will blocks a lot of brain receptors for neurotransmitters. Dopamine is important in thinking, emotions, behavior and perception. When there is too much dopamine in the brain, it may lead to symptoms such as hearing voices (hallucinations), or having ideas that people may be against you (paranoid delusions). It is even difficult for people to tell between what is real and what is imagined, and can make it difficult to think straight, express feelings, or behave appropriately.

NOTE: It is important to know that Clozapine is reserved only for people who have not done well with other medicines. Clozapine is prescribed by professionals in the treatment of mental health conditions only.

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Clozapine powder Raw Material, API comes in tablets form. Normally, it should be given orally. It also has some side effects that are considered lethal which explains why it was categorized under third line treatment. Clozapine has been proven to be more helpful in treating schizophrenia symptoms compared to older typical antipsychotic medications. Other indications for the drug include treating suicidal patients, paranoid individuals, manic patients, insomniacs and those suffering from schizoid personality, and dementia of the Lewy-body-type.

 

As a professional China Clozapine powder Raw Material, API supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Clozapine powder Raw Material, API from China in China for almost 10 years.

 

Solubility Data of Clozapine powder Raw Material, API:

In DMSO: 6.86Max Conc. mg/mL; 20 Max Conc. mM

In Ethanol: 3.43Max Conc. mg/mL; 10mM with gentle warming Max Conc. mM

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Side Effects:

Drowsiness is the most common side effect of Clozapine. Patients may also experience increased heart rate, headache, weight gain, sleepiness, tremor, increased salivation, hypotension, fever, blurred vision, difficulty urinating, constipation and paralytic ileus. Some symptoms may disappear after being on the drug for 48-72 hours. Rarely, Clozapine could also lead to extra-pyramidal effects or sudden involuntary movements of the extremities, eyes and head. One serious side effect of the Clozapine is agranulocytosis wherein white blood cell count drastically drops, which will make the patient vulnerable to infection and other diseases.

Precautions & Notes:

If Pregnant women and breastfeeding mothers want to take Clozapine, it is strongly suggested to ask the doctor for the permission first.

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COA of Clozapine :


     TESTS
     Appearance (Clozapine)
     Identification Clozapine
 A IR
 B By TLC
 Melting point
 Loss of Drying
 Residue on ignition
 Heavy metals
 Organic volative  impurities
 Ethanol
 Toluene
 DMF
 Assay (Clozapine)

SPECIFICATION
     Yellow crystalline powder

  

IR conforms to standard
       As per USP29
       182-186℃  
      Not more than 0.5%
      Not more than 0.1%
       Not more than 0.002%


             Not more than 5000ppm
             Not more than 890ppm
             Not more than 880ppm
             98.0-102.0%

OBSERVATION
     Up to standard


Positive
 Positive
       183.5-184.0℃  
       0.04%
       0.04%
       Not more than 0.002%

636ppm
       Below detected limited
       70ppm
       99.70%

Top Quality, China Pure Clozapine Powder/Substance factory in China; China Clozapine Raw Material Suppliers in China. China Clozapine API Manufacturers in China. 


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Clozapine Powder API, Raw Material CAS 5786-21-0


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Skype: frankrenful2002
E-Mail: frank_feng@fengchengroup.com
Tel: +86-186-7846 1007
WECHAT: +86-18678461007
WHATSAPP: +86-18678461007
Add: Room 1101, 5th Building, No.168 Shenzhen Road, Qingdao, China
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