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Clobetasol Propionate Powder Raw Material, API CAS 25122-46-7

Clobetasol Propionate Powder Raw Material, API CAS 25122-46-7

China Clobetasol Propionate Suppliers, China Clobetasol Propionate Manufacturers CAS 25122-46-7 Product Name: Clobetasol Propionate Powder Raw Material, API CAS 25122-46-7 Synonym s: Clobetasol 17 Propionate CAS Number: 25122-46-7 Characteristics: White to cream crystalline powder Assay: 97.0~ 102.0% (Clobetasol Propionate) Formula:...

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China Clobetasol Propionate Suppliers, China Clobetasol Propionate Manufacturers CAS 25122-46-7

Clobetasol Propionate Powder Raw Material, API.jpg

Product Name:  Clobetasol Propionate

Synonyms:  Clobetasol 17 Propionate

CAS Number: 25122-46-7

Characteristics: White to cream crystalline powder

Assay: 97.0~ 102.0% (Clobetasol Propionate)

Formula: C25H32ClFO5 

Clobetasol Propionate Powder Raw Material, API formula.gif

 

KEYWORD: Clobetasol Propionate Raw Material, API

Standard: USP, BP, EP

Package: 5kg/tin,2tins/carton.

RS of Clobetasol Propionate Powder Raw Material, API

Clobetasol Propionate Powder Raw Material, API spectrum.jpg

Description of Clobetasol Propionate Raw Material, API BP, EP, USP:

Clobetasol Propionate is a derivative of Prednisolone. It has high glucocorticoid activity and low mineralocorticoid activity. Clobetasol Propionate can be absorbed through the skin, and even faster than Fluocinonide. It is used topically to treat or cure Psoriasis.  Clobetasol Propionate may cause marked adrenocortical suppression.

Clobetasol Propionate is the propionate salt form of clobetasol. It is a topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. 

Clobetasol Propionate Raw Material, API BP, EP, USP is generally the most effective in acute or chronic dermatoses (e.g., seborrheic or atopic dermatitis, localized neurodermatitis, etc.

Clobetasol Propionate Raw Material, API BP, EP, USP will be made into Clobetasol Propionate cream, ointment, gel, lotion. It is very potent.

In general, Clobetasol Propionate is a synthetic corticosteroid, for topical dermatologic use. It belongs to an analog of prednisolone. Clobetasol Propionate has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.

 

Clobetasol propionate Property:

Characteristics:  a white or almost white crystalline powde

Odor: odorless,

Clobetasol propionate Solubility: insoluble in water.

Clobetasol propionate’s Chemical Name (11-β,16β)-21-Chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione

 

Mechanism:

Clobetasol propionate binds to cytoplasmic glucocorticoid receptors.  It subsequently activates glucocorticoid receptor mediated gene expression. By this way, Clobetasol propionate helps the synthesis of several anti-inflammatory proteins. At the same time, Clobetasol propionate inhibits the synthesis of some inflammatory mediators. Especially, Clobetasol Propionate will induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.

 

Usage:

Clobetasol Propionate is the raw material(API) to make finished drugs.

Formulation in the market:

Clobetasol Propionate Cream, Clobetasol Propionate Ointment, etc.

NOTE:

Clobetasol Propionate is for dermatologic use only; avoid contact with eyes. If such contact occurs, flush affected eye(s) with copious amounts of water

  

Clobetasol Propionate Side effects:

Common Adverse reactions: Burning or stinging at the application site

Not very common Adverse reactions of Clobetasol Propionate can be :

(1)Burning sensation of the skin, flushing or redness of the skin

(2)Dry skin

(3)Thinning of the skin with easy bruising, especially when use Clobetasol Propionate on the face or where the skin folds together (For example, between the fingers)

(4)Application of Clobetasol Propionate may cause itching, scaling, severe redness, soreness, or swelling of the skin

(5)skin irritation

(6) Clobetasol Propionate may also leads to skin rash, encrusted, scaly and oozing

  

COA of Clobetasol Propionate Raw Material, API BP, EP, USP

Product

Clobetasol    Propionate

Testing Item

Standard

Result

Appearance

White    to cream crystalline powder

Complies

Identification

Infrared Absorption
 -- Clobetasol    Propionate

Complies

Melting Point

Approximately 196°C

196.7°C

Specific    Rotation

+98°    ~ +104°

+103.0°

Loss    on drying

≤    2.0%

0.25%

Residual on Ignition

≤    0.1%

0.07%

Heavy    Metal

≤    20ppm

<    20ppm

Chromatographic    Impurity

Single    Impurity ≤ 1.0%
 Total    Impurity ≤ 2.5

0.20%
 0.36%

Residual    Solvents

Meets    the requirements

Complies

Particle Size

Micronized

Complies

Assay    (Clobetasol Propionate)

97.0%    ~ 102.0%

99.88%

Top Quality, China Pure Clobetasol Propionate Powder/Substance factory in China; China Clobetasol Propionate Raw Material Supplier in China. China Clobetasol Propionate API Manufacturer in China. 


If you are looking for the Clobetasol Propionate Powder Raw Material, API CAS 25122-46-7, welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.
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