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Celecoxib Powder Raw Material, API BP EP USP CAS 169590-42-5

Celecoxib Powder Raw Material, API BP EP USP CAS 169590-42-5

China Celecoxib Suppliers, China Celecoxib Manufacturers CAS 169590-42-5 Product Name: Celecoxib Powder Raw Material, API BP EP USP Chemical name: N-[4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1yl]phenylsulfonyl]benzensulfonamide 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide CAS Number:...

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China Celecoxib Suppliers, China Celecoxib Manufacturers CAS 169590-42-5

Celecoxib Powder Raw Material, API BP EP USP.png

Product Name: Celecoxib Powder Raw Material, API BP EP USP

Chemical name: N-[4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1yl]phenylsulfonyl]benzensulfonamide

4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

CAS Number: 169590-42-5

Characteristics: White or almost white crystalline or amorphous powder

Assay:  98.0% ~ 102.0% Celecoxib

Formula:  C17H14F3N3O2S

Structure Formula: 

Celecoxib Powder Raw Material, API BP EP USP formula.png

Package information: 10KGS/Fiber DrumCardboard DrumPaper Drum  

KEY Words: Celecoxib Powder Raw Material, API BP EP USP CAS 169590-42-5

Description:
Celecoxib is a selective cyclooxygenase-2 inhibitor. It has Anti-inflammatory function.
Celecoxib is used to treat familial adenomatous polyposis. It is a nonsteroidal anti-inflammatory drug.
Celecoxib is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain. It is also used in the treatment of hereditary polyps.
Celecoxib works by reducing hormones that cause inflammation and pain in the body.
Celecoxib is a pyrazole derivative and selective inhibitor, which is used to treat symptoms associated with arthritis, as well as the management of acute pain.

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Indications:

Celecoxib Powder Raw Material, API BP EP USP is proved and permitted for use in osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms. Celecoxib help to reduce the number of colon and rectal polyps in patients with familial adenomatous polyposis. It was originally intended to relieve pain while minimizing the gastrointestinal adverse effects usually seen with conventional NSAIDs. In the everyday usage, Celecoxib Powder Raw Material, API BP EP USP is prescribed in people who require regular and long term pain treating. It is probably no advantage to using Celecoxib Powder Raw Material, API BP EP USP for a very short term or acute pain relief over conventional NSAIDs. Moreover, the mechanism of action of celecoxib is similar to paracetamol.

 

Pharmacology:

Celecoxib Powder Raw Material, API BP EP USP is a highly selective COX-2 inhibitor and primarily inhibits this isoform of cyclooxygenase (inhibition of prostaglandin production), whereas traditional NSAIDs inhibit both COX-1 and COX-2. Celecoxib is approximately 7.6 times more selective for COX-2 inhibition over COX-1. Technically, this ability allows celecoxib to reduce inflammation or pain while minimizing gastrointestinal adverse drug reactions. These drug reactions are very common when we use them.

 

Celecoxib Adverse effects:

-Allergy may happen when using Celecoxib.

Celecoxib contains a sulfonamide moiety. There can be allergic reactions for the people who are allergic to related sulfonamide-containing substances. It is in addition to the contraindication in patients who have a history of allergy to these drugs.

-Gastrointestinal ADRs

Chemically, the COX-2 selectivity will cause a significantly lower incidence of gastrointestinal ulceration than traditional NSAIDs. The main body of evidence touted to support the above conclusion were the preliminary results of the Celecoxib Long-term Arthritis Safety Study, a famous research published in the year 2000, which suggested a significant reduction in the combination of symptomatic ulcers plus ulcer complications in those who take celecoxib VS ibuprofen or diclofenac, provided they were not on aspirin. But itwas not significant at 1-year-length.

-There also can be heart attack and stroke risks after using Celecoxib Powder Raw Material, API BP EP USP

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Usage Guide of Celecoxib:

In order to minimize the chances of stomach upset, Celecoxib Powder Raw Material, API BP EP USP is better to be taken together with foods. The dosage of Celecoxib depends on medical condition and response to treatment. Take Celecoxib at the lowest effective dose and only for the regulated time period.

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Precautions and Notes of Celecoxib:

Celecoxib is contraindicated in people who have had an allergic-type reaction to sulfonamide drugs. This agent is not recommended either for the people who have severe hepatic insufficiency or advanced renal disease.

It should also aware that in some cases patients who receive Celecoxib concurrently with warfarin experienced bleeding events in association with an increase in prothrombin time. Thus, if there is a celecoxib therapy changing, the International Normalized Ration should be monitored, which is especially true in the first few days. Moreover, there is also the possibility that a potential interaction with lithium and cytochrome P450 inhibitors when patients are taking Celecoxib Powder Raw Material, API BP EP USP containing drugs.

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Particle size of Celecoxib:
Our Celecoxib is very small in particle size.


As a professional China Celecoxib BP, EP, USP API supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Celecoxib raw material from China for almost 10 years.

 

Uses and functions of Celecoxib:

1. Celecoxib raw material will relieve osteoarthritis Symptoms and problems.

2. Celecoxib API can treat and relieve adult rheumatoid arthritis symptoms.

3. Another usage of Celecoxib is for treatment of adult acute pain .


Other Names for this product:

Celecoxib; 4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide; Celebrex; SC-58635; 4-(5-(4-Methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonimide; celebra; celebrex; 4 [5 (4 methylphenyl) 3 trifluoromethyl 1h pyrazol 1yl]benzenesulfonamide; sc 58635; ym 177; 4 [5 (4 methylphenyl) 3 trifluoromethyl 1h pyrazol 1 yl]benzenesulfonamide;


Main indexes of Celecoxib:

Testing Item

Standard

Result

Appearance
     Celecoxib

White or almost white crystalline or amorphous powder

Positive

Identification A
Celecoxib

IR Spectrum comply with the RS

Complies

Identification B
Celecoxib

RRT comply with standard solution.

Complies

Solubility

Freely soluble in ethanol; Soluble in methylene chloride; practically insoluble in water

Complies

Heavy Metal

≤  20ppm

< 20ppm

Water (KF)

≤  0.5%

0.19%

Residual on Ignition

≤  0.2%

0.10%

Impurity A

≤  0.4%

Not detected.

Impurity B

≤  0.10%

0.085%

Impurity C

≤  0.10%

Not detected.

Impurity D

≤  0.10%

0.006%

Impurity E

≤  2.5ppm

Not detected.

Impurity F

≤  0.10%

Not detected.

Max Single impurity

≤  0.10%

0.003%

Total Impurity

≤  0.5% 

0.11%

Methanol

≤  3000ppm

150ppm

Ethanol

≤  5000ppm

820ppm

Toluene

≤  890ppm

Not detected.

Assay

98.0 ~ 102.0% Celecoxib

100.0%

This product complies with USP35 standard.

Top Quality, China Pure Celecoxib Powder/Substance factory in China; China Celecoxib Raw Material Suppliers in China. China Celecoxib API Manufacturers in China. 


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Celecoxib Powder Raw Material, API BP EP USP CAS 169590-42-5

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