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Captopril Power API, Raw Material BP, EP, USP CAS 62571-86-2

Captopril Power API, Raw Material BP, EP, USP CAS 62571-86-2

China Captopril Suppliers, China Captopril Manufacturers CAS 62571-86-2 Product Name: Captopril Power API, Raw Material BP, EP, USP CAS 62571-86-2 Synonyms: Captoprilum, Captopri CAS Number: 62571-86-2 Chemical name: (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid Characteristics: White to off-white crystalline powder,...

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China Captopril Suppliers, China Captopril  Manufacturers CAS 62571-86-2

Captopril Power API, Raw Material BP, EP, USP.jpg

Product Name: Captopril Power API, Raw Material BP, EP, USP

Synonyms: Captoprilum, Captopri, Capoten

CAS Number: 62571-86-2

Chemical name: (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid

Characteristics: White to off-white crystalline powder, sulfide-like odor

Assay: 97.5% ~ 102.0% Captopril

Formula: C9H15NO3S

Structure Formula:

Captopril Power API, Raw Material BP, EP, USP formula.jpg

Package information: 25Kgs/Drum

KEY Words: Captopril Power API, Raw Material BP, EP, USP

Standard: USP37 Standard Captopril.


Description:

Captopril is a substance which is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II.

Captopril suppresss the renin-angiotensin system, further more it inhibits pressure responses to exogenous angiotensin.

The mechanism of action of Captopril:

Captopril an Angiotensin-converting Enzyme Inhibitor.

The chemical Name is: C9H15NO3S. As an angiotensin-converting enzyme (ACE) inhibitor drug substance, Captopril will help to treat hypertension (High blood pressure), congestive heart failure, and some other cardiovascular disorders. Captopril will relax our blood vessels so that blood can flow more easily. Angiotensin-converting enzyme  is the enzyme responsible for the conversion of angiotensin I to angiotensin II.

 

With Captopril’s help, blood pressure will be kept lower. This will benefit us a lot. Captopril Raw Material API BP, EP, USP will prevent strokes, heart attacks, and kidney problems. It also protects the kidneys from harms due to diabetes. Moreover, Captopril will help patient after a heart attack, increasing the survival rate from heart attacks. 

Usage:

Captopril raw material are used to produce finished medicine like Captopril Tablets.

Captopril is an Angiotensin Converting Enzyme Inhibitor. it competitively inhibits angiotensin converting enzyme (ACE). Captopril may also inhibit tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (MMPs) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis.

Precautions and Warnings:

- Captopril is not suitable for pregnant women. We should stop captopril immediately once pregnancy is found.  

- Captopril will act directly on the renin-angiotensin system. This will cause fatal damage to developing fetus.  

- Further more, people with history of or still suffer from diabetes should pay special attention before using Captopril.  

- Aliskiren is not working well together with Captopril. So be careful.

 

Captopril Raw Material USP, BP, EP may be used as initial therapy for patients with normal renal function, in whom the risk is relatively low. In patients with impaired renal function, particularly those with collagen vascular disease, Captopril should be reserved for hypertensives who have either developed unacceptable side effects on other drugs, or have failed to respond satisfactorily to drug combinations.

Captopril is effective alone or in combination with other antihypertensive agents, especially thiazide-type diuretics. The blood pressure lowering effects of captopril and thiazides are approximately additive.

 

Heart Failure:

In conjunction with diuretics and digitalis, Captopril contributes in the treatment of congestive heart failure usually.

 

Diabetic Nephropathy:

Captopril can also be indicated for the treatment of diabetic nephropathy (proteinuria >500 mg/day) in patients with type I insulin-dependent diabetes mellitus and retinopathy. Captopril decreases the risk of progression of renal insufficiency and development of serious adverse clinical outcomes.

 -----------------------

Common Side Effects of Captopril:

Captopril may lead to the following unwanted side effects (Not serious):

Flushing, Cough, Lightheadedness, Tiredness, Mild itching or skin rash, Salty or metallic taste, or reduced ability to taste, Numbness, tingling, or burning sensation in your hands or feet, etc.

 Serious Side Effects of Captopril includes:

Stomach pain, Chest pain, Rapid weight gain, Little or no urination, Prolonged diarrhea or vomiting etc.

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COA of Captopril

Name of Product

Captopril

Testing Item

Standard

Result

Appearance

White to off-white crystalline powder, sulfide-like odor

Complies

Identification (Captopril)

Infrared Absorption

Complies

Appearance of Captopril solution

Clear and colorless

Conforms

Melting Point

104°C ~ 110°C

106°C ~ 107°C

Specific Rotation

-125° ~ -134°

-129°

Loss on drying (Captopril)

≤ 1.0%

0.02%

Sulfated Ash

≤ 0.2%

0.09%

Heavy Metal

≤ 30ppm

< 20ppm

Captopril disulfide

≤ 1.0%

0.31%

Single unknown impurity

≤ 0.2%

Not detected

Total unknown impurities

≤ 0.5%

Not detected

Assay (Captopril)

97.5% ~ 102.0%

99.7%


Top Quality, China Pure Captopril Powder/Substance factory in China; China Captopril Raw Material Suppliers in China. China Captopril API Manufacturers in China. 


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Captopril Power API, Raw Material BP, EP, USP CAS 62571-86-2

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