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Ribavirin Powder API Raw material CAS 36791-04-5

Ribavirin Powder API Raw material CAS 36791-04-5

China Ribavirin Suppliers, China Ribavirin Manufacturers CAS 36791-04-5 Product Name: Ribavirin Powder API Raw material CAS 36791-04-5 Synonyms: Ribavirine Chemical name: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide CAS Number: Ribavirin; 36791-04-5 Characteristics: White crystalline powder Assay: 98.5% ~ 101.5% Formula:...

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Product Details

China Ribavirin Suppliers, China Ribavirin Manufacturers CAS 36791-04-5

Ribavirin Powder API Raw material.png

Product Name: Ribavirin

Synonyms: Ribavirine

Chemical name: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

CAS Number: Ribavirin; 36791-04-5

Characteristics: White crystalline powder

Assay:  98.5% ~ 101.5%

Formula: C8H12N4O5

Structure Formula: 

Ribavirin Powder API Raw material structure.png

Package information: 25Kgs/Drum
KEY Words: Ribavirin Powder API Raw material CAS 36791-04-5

Description and usage:
Ribavirin is synthetic substance. It belongs to nucleoside antimetabolite anti-viral substance. Ribavirin blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
It is a nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses. Ribavirin is incorporated into viral RNA, thereby inhibiting viral RNA synthesis, inducing viral genome mutations, and inhibiting normal viral replication.

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Ribavirin Powder API Raw material CAS 36791-04-5, also known as tribavirin, is an antiviral medication used to treat RSV infection, hepatitis C, and viral hemorrhagic fever. For hepatitis C it is used with other medications such as simeprevir, sofosbuvir, peginterferon alfa-2b or peginterferon alfa-2a. Among the viral hemorrhagic fevers it is used for Lassa fever, Crimean–Congo hemorrhagic fever, and Hantavirus infection but not Ebola or Marburg. Ribavirin can be taken orally or be inhaled.

 

As a professional China Ribavirin Powder API Raw material supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Ribavirin Powder API Raw material from China in China for almost 10 years.

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Ribavirin is an anti-viral drug indicated for severe RSV infection (individually), hepatitis C infection (used in conjunction with peginterferon alfa-2b or peginterferon alfa-2a) and other viral infections. Ribavirin is a prodrug, which when metabolised resembles purine RNA nucleotides. In this form it interferes with RNA metabolism required for viral replication. How it exactly affects viral replication is unknown; many mechanisms have been proposed for this but none of these has been proven to date. Multiple mechanisms may be responsible for its actions.

As an antiviral drug, Ribavirin is used in combination with interferon for the treatment of chronic hepatitis C.

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1.Ribavirin oral tablet is available as a brand-name drug and a generic drug.

2.Ribavirin comes as an oral tablet, oral capsule, oral solution, and inhalant solution.

3.Ribavirin oral tablet is used to treat chronic hepatitis C virus infection.

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Indications:

Ribavirin is indicated for the treatment of hospitalized infants and young children with severe lower respiratory tract infections due to respiratory syncytial virus. Treatment early in the course of severe lower respiratory tract infection may be necessary to achieve efficacy.

 

Only severe RSV lower respiratory tract infection should be treated with Ribavirin. The vast majority of infants and children with RSV infection have disease that is mild, self-limited, and does not need Ribavirin’s help.

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Side effects of Ribavirin:

-Swelling and irritation of pancreas (pancreatitis). There can also be tomach pain, nausea, vomiting, or diarrhea.

- Ribavirin may cause severe depression

- Serious breathing problems. Difficulty breathing may occur. It is a sign of a serious lung infection (pneumonia) which can be fatal.

- Excessive Ribavirin usage may lead to serious eye problems.

- Dental problems. Teeth and gums deseases.

- Severe blood disorders may also be an unwanted side effects of Ribavirin. The risk will be even higher if it is used in combination with pegylated alpha interferons and azathioprine

-Weight loss and slowed growth in children may also happen.

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-The most common side effect seen with the combination of ribavirin and interferon is a flu-like syndrome including: chills, body aches and pains, headache, fever.

-Other possible side effects that may occur during therapy with ribavirin and interferon are:

fatigue, nausea, insomnia, weakness, anorexia, breathing difficulties, heartburn, irritability, rash, itching, etc.

-The most serious side effect seen with ribavirin is anemia. Careful consideration is advised if Ribavirin is used in patients with heart or circulation problems since the anemia may aggravate these conditions.

Other Side effects:

Ribavirin Powder API Raw material CAS 36791-04-5 may make you feel tired, headache, nausea, fever, muscle pains, and an irritable mood.

Serious side effects of Ribavirin Powder API Raw material CAS 36791-04-5 includes red blood cell breakdown, liver problems, and allergic reactions. Use during pregnancy results in harm to the baby. Effective birth control is recommended for both males and females for 7 months after use. The mechanism of action of ribavirin is not entirely clear.

 

NOTES: Ribavirin should be avoided among patients who have severe kidney disease and have lost most of their kidneys' function.

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Ribavirin Mechanisms of action:

Ribavirin Powder API, raw material BP, EP, USP is a guanosine (ribonucleic) analog used to stop viral RNA synthesis and viral mRNA capping, for this reason, Ribavirin is a nucleoside inhibitor. Ribavirin is a prodrug, which when metabolized resembles purine RNA nucleotides. In this form, Ribavirin will help to interfere with RNA metabolism required for viral replication. Researches and studies already proved that there are more than 5 direct and indirect Ribavirin’s mechanism of action.

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Warnings:

Ribavirin tablets monotherapy is not working for the treatment of chronic hepatitis C virus infection and should not be used alone for this indication.

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COA of Ribavirin:


     Testing Item

Standard

Result

Appearance
Ribavirin

White crystalline powder

Complies

Identification 1
Ribavirin

Infrared Absorption

Complies

Identification 2
Ribavirin

TLC

Complies

Specific Rotation

-33.5° ~ -37.0°

-36.2°

pH

4.0 ~ 6.5

4.6

Loss on drying

≤  0.5%

0.1%

Residual on Ignition

≤  0.1%

0.02%

Heavy Metal

≤  10ppm

10ppm

Chromatographic Impurity

Each impurities surface area ≤  0.25% of the general peek area

0.02%

The total impurities surface area ≤  1.0% of the general peek area

0.1%

Assay
Ribavirin

98.5% ~ 101.5%

99.8%

Property of Ribavirin:

Ribavirin is a stable, white crystalline compound with a maximum solubility in water of 142 mg/mL at25°C and with only a slight solubility in ethanol. The empirical formula is C8Hl2N405 and the molecular weight is 244.21.

 

Top Quality, China Pure Ribavirin Powder/Substance factory in China; China Ribavirin Raw Material Suppliers in China. China Ribavirin API Manufacturers in China. 


If you are looking for the Ribavirin Powder API Raw material CAS 36791-04-5, welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.
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