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Sulfamethoxazole or Sulphamethoxazole CAS 723-46-6 BP EP USP

Sulfamethoxazole or Sulphamethoxazole CAS 723-46-6 BP EP USP

Sulfamethoxazole or Sulphamethoxazole CAS 723-46-6 BP EP USP Product Name: Sulfamethoxazole Synonyms: Sulphamethoxazole, SMZ, Sulfamethoxazolum CAS Number: 723-46-6 Characteristics: white or almost white crystalline powder. Solubility: sparingly soluble in 96% ethanol; freely soluble in acetone;...

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Sulfamethoxazole or Sulphamethoxazole CAS 723-46-6 BP EP USP

                                              Sulfamethoxazole or Sulphamethoxazole BP EP USP.jpg

Product Name: Sulfamethoxazole

Synonyms:  Sulphamethoxazole, SMZ, Sulfamethoxazolum

3-(p-Aminophenylsulfonamido)-5-methylisoxazole, 3-Sulfanilamido-5-methylisoxazole

CAS Number: 723-46-6

Characteristics: white or almost white crystalline powder.

Solubility: Sulfamethoxazole is sparingly soluble in 96% ethanol; freely soluble in acetone; practically insoluble in water. Sulfamethoxazole(SMZ) dissolves in dilute solutions of sodium hydroxide and in dilute acids.

 

Assay(Content): > 99% Sulfamethoxazole

Formula: C10H11N3O3S    Molecular Weight: (Average)253.28

 

Sulfamethoxazole or Sulphamethoxazole BP EP USP Formula.gif

Package information: 25Kgs/Drum

HS.Code: 29350030

Description: Sulfamethoxazole also spells Sulphamethoxazole, it is a bacteriostatic antibacterial substance which interferes with dihydrofolic acid synthesis in the susceptible bacteria. Sulfamethoxazole has broad spectrum of activity.  There an be drug resistance.

Sulfamethoxazole belongs to aminobenzenesulfonamides. They are organic compounds which contains a benzenesulfonamide moiety with an amine group attached to the benzene ring, chemically.

 

Sulfamethoxazole is usually taken in combination with Trimethoprim. TMP is a dihydrofolate reductase inhibitor, which inhibits the reduction of dihydrofolic acid to tetrahydrofolic acid. Researches prove that bacterial resistance develops much more slowly if given the combination of the two drugs than just with either TMP or Sulfamethoxazole(SMZ) alone.

 

As a professional China Sulfamethoxazole Powder supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Sulfamethoxazole Powder from China for almost 10 years.

 

Mechanism of Action of Sulfamethoxazole::

Sulfamethoxazole inhibits dihydrofolic acid synthesis, decreases the synthesis of bacterial nucleotides and DNA. Then there will be an inhibition for the bacterial cell growth. Pyrimethamine and trimethoprim act synergistically with the Sulfamethoxazole. They can be used together.

Sulfamethoxazole is Effective Against: 1.Gam negative bacterial or gram positive bacteria 2. Escherichia coli, 3. Listeria monocytogenes

 

Absorption of Sulfamethoxazole:

It will be rapidly absorbed through oral administration.


Usage: Sulfamethoxazole(Sulphamethoxazole, SMZ) can be independently used to produce Sulfamethoxazole Oral Suspension, Sulfamethoxazole Tablets. It can also be used together with Trimethoprim(TMP) to make Injections, Tablets and other preparations.

For veterinary drugs making: There is also a big range of using for making veterinary medicines.



Toxicity of Sulfamethoxazole:

There can be nausea, vomiting, diarrhea and hypersensitivity reactions.


 CERTIFICATE OF ANALYSIS

Appearance

Sulfamethoxazole

A   white or almost white crystalline power

Complies

Solubility

Practically   insoluble in water, freely soluble in acetone, sparingly soluble in alcohol,   slightly soluble in ether. It dissolves in dilute solutions of sodium   hydroxide..

Complies

Identification   A

(Sulfamethoxazole)

Melting   point: 169°C ~ 172°C

170°C ~   170.5°C

Identification   B

(Sulfamethoxazole)

IR: As per   the spectrum of sulfamethoxazole CRS

Complies

Identification   C

(Sulfamethoxazole)

TLC: As per   BP2002

Complies

Identification   D

(Sulfamethoxazole)

Chemical   Test: Give reaction of primary Aromatic amines

Complies

Appearance   of solution

≤ Y5  ≤ BY5 ≤ GY5

Complies

Acidity

≤ 0.3ml of 0.1M NaOH

0.23ml

Related   substances by TLC

≤ 0.5%

0.25%

Heavy Metal

≤ 20ppm

<20ppm

Loss on   drying

≤ 0.5%

0.2%

Sulfated ash

≤ 0.1%

0.03%

Assay

99.0%   ~101.0% (Sulfamethoxazole)

99.8%

CONCLUSION

Comply with   BP2010 Standard.

Cautions:

As with all drugs containing Sulfamethoxazole, caution is advisable in patients with porphyria or thyroid dysfunction.

Patients should be counseled that sulfamethoxazole should only be used to treat bacterial infections. Sulfamethoxazole does not treat viral infections (e.g., the common cold). When Sulfamethoxazole are prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, it should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance. 


Top Quality, Pure Sulfamethoxazole(Sulphamethoxazole, SMZ) Powder;  Sulfamethoxazole(SMZ) Raw Material Supplier in China. Sulfamethoxazole API Manufacturer.

If you are looking for the sulfamethoxazole or sulphamethoxazole cas 723-46-6 bp ep usp, welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.

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Skype: frankrenful2002
E-Mail: frank_feng@fengchengroup.com
Tel: +86-186-7846 1007
WECHAT: +86-18678461007
WHATSAPP: +86-18678461007
Add: Room 1101, 5th Building, No.168 Shenzhen Road, Qingdao, China
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