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Polymyxin B Sulfate or Polymyxin B Sulphate Raw Material, API CAS 1405-20-5

Polymyxin B Sulfate or Polymyxin B Sulphate Raw Material, API CAS 1405-20-5

Polymyxin B Sulfate or Polymyxin B Sulphate Raw Material, API CAS 1405-20-5 Product Name: Polymyxin B Sulfate or Polymyxin B Sulphate Synonyms: Sulfate, Polymyxin B, Aerosporin CAS Number: 1405-20-5 Characteristics: White or almost white powder, hygroscopic Formula: C56H100N16O17S Structure Formula: Package...

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Polymyxin B Sulfate or Polymyxin B Sulphate CAS 1405-20-5

Polymyxin B Sulfate or Polymyxin B Sulphate Raw Material, API.png


Product Name: Polymyxin B Sulfate or Polymyxin B Sulphate

Synonyms: Sulfate, Polymyxin B, Aerosporin

CAS Number: 1405-20-5

Characteristics: White or almost white powder, hygroscopic

Formula: C56H100N16O17S

Structure Formula: 

Polymyxin B Sulfate or Polymyxin B Sulphate Raw Material, API formula.png

Package information: 2Kg/Tin; 1Kg/Tin
KEY Words: Polymyxin B Sulfate, Polymyxin B Sulphate API, Raw Material Powder

Function:
Polymyxin B Sulfate or Polymyxin B Sulphate is Antibiotic with bactericidal action on E. coli.

Polymyxin B Sulfate is a mixture of polymyxins B1 and polymyxins B2. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes.
Polymyxin B Sulfate is used for infections with gram-negative organisms.

Polymyxin B Sulfate is popularly used togethr with Trimethoprim, making a famous formulation Polymyxin B Sulfate-Trimethoprim eye drops. It contains 2 antibiotics. Polymyxin B Sulfate API, Raw Material Powder will eliminate the bacteria, while Trimethoprim works by stopping the growth of the bacteria. Polymyxin B sulfate (PMB) is a strongly cationic cyclic polypeptide antibiotic isolated from fermentation of Bacillus.

 

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Polymyxin B for Injection is one of a group of basic polypeptide antibiotics derived from B polymyxa (B aerosporous). Polymyxin B (polymyxin b sulfate) sulfate is the sulfate salt of Polymyxins B1 and B2, which are produced by the growth of Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillacea). It has a potency of not less than 6000 polymyxin B (polymyxin b sulfate) units per mg, calculated on the anhydrous basis.

Aqueous solutions of polymyxin B (polymyxin b sulfate) sulfate may be stored at least 1 year without significant loss of potency if properly kept. Considering the safety, Polymyxin B sulfate should not be stored in alkaline solution. Because is will become not as stable as in normal conditions.

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As a professional China Polymyxin B Sulfate Raw Material supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Polymyxin B Sulfate API from China in China for almost 10 years.

 

Indications:

Polymyxin B Sulfate API, Raw Material Powder indicates for Acute Infections Caused by Susceptible Strains of Pseudomonas aeruginosa.

Polymyxin B  sulfate firstly considered to be a choice in the treatment of infections of the urinary tract, meninges, and bloodstream caused by susceptible strains of Ps. aeruginosa. It may also be utilized topically and subconjunctivally in the treatment of infections of the eye caused by susceptible strains of Ps. aeruginosa.

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Storage / Stability as Supplied:

Polymyxin B Sulfate API, Raw Material Powder should be stored at 2-8°C in the dark. The shelf life can be at least 3 years.

Solubility / solution stability:

A solution of Polymyxin B sulfate in water at 50 mg/mL is clear to very slightly hazy, colorless to yellow in appearance. Polymyxin B sulfate has only minimal solubility in any organic solvent, for example, 0.115 mg/mL in ethanol.

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COA of Polymyxin B Sulfate:


     Tests

Specifications

Results

Description
     Polymyxin B Sulfate

White or almost white powder, hygroscopic

White powder

Identification
     Polymyxin B Sulfate

LC identification test, Conforms

Conforms

A reddish violet color is produced, Conforms

Meets the requirements of the test for Sulfate ,Conforms

PH

5.0~7.5

6.4

Loss on drying

≤7.0%

3.7%

Residue on ignition

≤5.0%a

0.27%


Related substances, HPLC

Any impurity:   ≤3.0%
     Sum of impurity: ≤17.0%

2.0%
     11.0%

Heavy metals

≤20ppm

Conform

Total viable aerobic count

≤100cfu/g

Conform

Potency(Dried basis)

≥6000iu/mg

8078iu/mg

Assay HPLC (Dried basis)
Polymyxin B Sulfate

Sum of polymyxin B1, B2, B3 and B1-I:
≥80.0%
Polymyxin B3:  ≤6.0%
Polymyxin B1-I:  ≤15.0%


84.5%
2.0%
 7.0%

Particle size

99.0%: Not more than 30µm by vol.
90.0%: Not more than 20µm by vol
75.0%: Not more than 15µm by vol
50.0%: Not more than 10µm by vol
Mean diameter: Not more than 15µm

Conforms

Conclusion: Complies with USP39

Top Quality, China Pure Polymyxin B Sulfate (Polymyxin B Sulphate) Powder/Substance factory in China; China Polymyxin B Sulfate (Polymyxin B Sulphate) Raw Material Suppliers in China. China Polymyxin B Sulfate (Polymyxin B Sulphate) API Manufacturers in China. 


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Polymyxin B Sulfate Or Polymyxin B Sulphate Raw Material, API CAS 1405-20-5


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Skype: frankrenful2002
E-Mail: frank_feng@fengchengroup.com
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Add: Room 1101, 5th Building, No.168 Shenzhen Road, Qingdao, China
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