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Nifuroxazide BP EP USP CAS 965-52-6

Nifuroxazide BP EP USP CAS 965-52-6

Nifuroxazide BP EP USP CAS 965-52-6 Product Name: Nifuroxazide Synonyms: Ercefuryl, Bacifurane, p-Hydroxybenzoic acid (5-nitrofurfurylidene) hydrazide CAS Number: 965-52-6 Characteristics: bright light yellow crystalline powder Assay: 98.5% ~ 101.5% (dried substance). Formula: C12H9N3O5...

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Nifuroxazide BP EP USP CAS 965-52-6                                              Nifuroxazide BP EP USP API raw material.jpg

Product Name:  Nifuroxazide

Synonyms: Ercefuryl, Bacifurane, p-Hydroxybenzoic acid (5-nitrofurfurylidene) hydrazide

CAS Number: 965-52-6

Characteristics: bright light yellow crystalline powder

Assay:  98.5% ~ 101.5% (dried substance, Nifuroxazide).

Formula: C12H9N3O5

Molecular Weight: 275.2

Nifuroxazide BP EP USP API raw material formula.gif 

Package: 25Kg/Fiber DrumCardboard DrumPaper Drum

Storage: Sealed container, avoid direct sunlight.

Shelf Life: 4 years.


Description:

Nifuroxazide also called Ercefuryl, Bacifurane , belongs to nitrofuran antibiotics. It is usually taken orally. Nifuroxazide is mainly used to treat colitis and diarrhoea in humans and animals.

 

Other names of Nifuroxazide:

Nifuroxazidum (Latin)

Nifuroxazid (German)

Nifuroxazide (French)

Nifuroxazida (Spanish)

 

Nifuroxazide Mechanism of Action:

Being acceptors of oxygen, Nifuroxazide will inhibit the nucleic acids biosynthesis and cellular respiratio. Depending on blood concentration, Nifuroxazide may exert bacteriostatic or bactericidal effect.

 

As a professional China Nifuroxazide powder Raw Material supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Nifuroxazide powder API from China for almost 10 years.


Usage and applications:  

Nifuroxazide (Ercefuryl) is a good orally taken Nitrofuran anti-bacteria substance.  

Nifuroxazide Powder Raw material are used to produce finished drugs for human and animals. 


Nifuroxazide Indications:

- Treatment of diarrhea caused by infection sensitive to Nifuroxazide;
- Nifuroxazide will also treat chronic colitis and enterocolitis;
- Nifuroxazide will also prevent infections in abdominal operations


Side effects:
Usually Nifuroxazide won’t cause side effects.  But in rare cases, there can be dyspepsia and diarrhea.  Side effects may not require medical treatment or discontinuation of the drug.
In cases of allergic reactions (such as cutaneous rash, urticaria, angioedema, anaphylactic shock), Nifuroxazide should not be taken for safety.

 

Nifuroxazide Contraindications:
Hypersensitivity to the nitrofuran derivative or any subsidiary components of the drug nifuroxazide.

 

Nifuroxazide Overdose:
Cases of overdose are not known. If there was a significant excess of the therapeutic dose nifuroxazide need a gastric lavage.

 

NOTE: Nifuroxazide should not be used to pregnant women.


Certificate of Analysis-- Nifuroxazide

Testing Item

Standard

Result

Appearance

Bright   yellow crystalline powder

Bright   yellow crystalline powder 

Solubility  

Practically   insoluble in water,slightly soluble in alcohol and practically insoluble in   methylene chloride

Conforms  

Loss   on drying

≤0.5%  

0.22%

Heavy   metal(Pb)

≤0.002   %

Complies

Sulphated   ash

≤0.1%  

0.033%

Identification (Nifuroxazide)  By IR

The   IR spectrum matches Nifuroxazide standard spectrum

Complies

Impurity   A

≤0.05%  

0.04%

Related   substance

(the   ratio of area)

Relative   retention : with reference to nifuroxazide (retention time =about 8 min)

Impurity   A =about 0.36 and 0.39

Impurity   E =about 0.9

Impurity   B =about 1.2,

Impurity   C =about 2.6,

Impurity   D = about 3.4.

Complies

Impurity   peak area :

impurity   B ,C, D: for each impurity ,not more than 0.6 times the area of the principal   peak

Impurity   E: NMT 0.3%

Impurity   B, C, D: each impurity NMT 0.3%, and NMT one such peak has an area greater   than 0.1%.and NMT one such peak has an area greater than 0.2 times the area   of the principal peak.

Unspecified   impurities: each impurity NMT 0.1%

Sum   of impurities other than E: 0.5%

Complies


UV.   Absorption

The   specific absorption at about 367nm is between 940-1000

Complies

RESIDUAL   SOLVENTS

Methanol   ≤   0.3%

Alcohol   ≤   0.5%

Acetic acid ≤   0.5%

NMP   ≤0.05%

Not   Detected

0.02%

Not   Detected

Not   Detected

Assay   ( on dried basis)

98.5%   ~ 101.5% Nifuroxazide

99.6%

 

Top Quality, Pure Nifuroxazide Powder;  Nifuroxazide Raw Material Supplier in China. Nifuroxazide API Manufacturer. 


RE

Related similar product you may interested:    

Nifuroxazide




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