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Kanamycin Mono Sulfate 25389-94-0 CAS And Kanamycin Acid Sulfate CAS 64013-70-3

Kanamycin Mono Sulfate 25389-94-0 CAS And Kanamycin Acid Sulfate CAS 64013-70-3

Kanamycin Monosulfate CAS 25389-94-0 and Kanamycin Acid Sulfate Raw Material, API CAS 64013-70-3 Keywords: Kanamycin Sulfate, Kanamycin Sulphate; Kanamycin Acid Sulfate Description: Kanamycin Sulfate (Kanamycin Mono Sulphate) is used to fight against various serious infections, such as pneumonia, septicemia and...

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Kanamycin Mono Sulfate 25389-94-0 CAS  and Kanamycin Acid Sulfate CAS 64013-70-3

Kanamycin Mono Sulfate, Kanamycin Acid Sulfate.png

Product Name:

Kanamycin Mono Sulfate

Kanamycin Monosulfate

Kanamycin Acid Sulfate

Synonyms:

Kanamycin Sulfate, Kanamycin Sulphate

Kanamycin Acid Sulphate

Characteristics:

White or almost white crystalline powder

White or almost white crystalline powder

CAS Number:

25389-94-0

64013-70-3

Assay

750u/mg Min.
     Kanamycin Mono Sulfate

670IU/mg Min.
     Kanamycin Acid Sulfate

Formula:

C18H36N4O11,H2SO4,H2O

C18H36N4O11.H2SO4.H2O

C18H38N4O15S

C18H36N4O11 · 2 H2SO4

Structure:

Kanamycin Mono Sulfate, Kanamycin Acid Sulfate formula.png

Kanamycin Mono Sulfate, Kanamycin Acid Sulfate structure.png

Package:

15Bou/Drum

5Bou/Tin; 2Tin/CTN;

NOTE:

Non-Sterile

Sterile

Keywords: Kanamycin Sulfate, Kanamycin Sulphate; Kanamycin Acid Sulfate Raw Material, API

Description:
Kanamycin Sulfate (Kanamycin Mono Sulphate) is used to fight against various serious infections, such as pneumonia, septicemia and abdominal infections etc.
 Kanamycin Acid Sulfate is an aminoglycoside antibiotic which binds to 70S ribosomal subunit. It will inhibit translocation and eliciting miscoding. Kanamycin Acid Sulfate has anti-microbial activity to Gram-negative and -positive bacteria and mycoplasm.

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It is recommended for use in cell culture applications at 100 mg/L.

Kanamycin sulfate is an antimicrobial agent effective against Gram-negative and Gram-positive bacteria and mycoplasma. It binds to the 70S ribosomal subunit, inhibits translocation, and elicits miscoding. Cross-resistance occurs between kanamycin and neomycin, framycetin, and paromomycin, and partial cross-resistance has been reported between kanamycin and streptomycin. 1Aminoglycosidemodifying enzymes (acetyltransferase, phosphotransferase, nucleotidyltransferase) alter the antibiotic, preventing its interaction with ribosomes.

 

Kanamycin sulfate (Kanamycin sulphate) can be added into agar (agarplate), and the plate should be then be sealed to prevent any evaporation of moisture from the agar. The sealed plate can be stored at 2-8 °C for about 30 days. If the plate is not sealed to prevent evaporation of moisture, the kanamycin sulfate will degrade.

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Kanamycin sulfate and Kanamycin Acid Sulfate are both antibiotics typically used against prokaryotes. Aminoglycosides like Kanamycin sulfate and Kanamycin Acid Sulfate will "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically, kanamycin binds to 4 nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.

 

As a professional China Kanamycin sulfate and Kanamycin Acid Sulfate Raw Material supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Kanamycin sulfate and Kanamycin Acid Sulfate API from China in China for almost 10 years.


Usage:
Kanamycin Sulfate is a kind of broad spectrum antibiotic.
Kanamycin sulfate is an aminoglycoside-antibiotic with broad anti-bacterial spectrum, (including mycobacteria, many gram-positive and most gram-negative organisms).

COA of Kanamycin Mono Sulfate (Kanamycin Monosulfate):

Items

SPECIFICATION

RESULT

Appearance
Kanamycin Mono Sulfate

White or almost white crystalline powder

Complies

Identification
Kanamycin Sulfate

Positive

Positive

Pyrogens

In a solution containing 10mg/ml, approved

approved

Abnormal Toxicity

In a solution containing 2mg/ml, approved

approved

Specific optical rotation
Kanamycin Sulfate

+112-+123

+119

Loss on drying

≤1.5%

0.62%

Sulphate

15.0%-17.0%

16.2%

Sulphate Ash

≤0.5%

0.06%

Kanamycin B

≤4% Thin-Layer chromato graphy

2%

pH

6.5-8.5

7.8

Assay 

Kanamycin Mono Sulfate

Not less than 750u/mg

768U/mg

Property of Kanamycin Sulfate:

Name: Kanamycin Sulfate

EINECS: 246-933-9

Kanamycin Sulfate Melting Point: 250 °C

Formula: C18H36N4O11•H2O4S

Kanamycin Sulfate Boiling Point: 943.2 °C at 760 mmHg

Flash Point: 524.2 °C


COA of Kanamycin Acid Sulfate


     Testing Item

Standard

Result

Appearance
Kanamycin Acid Sulfate

White or almost white crystalline powder.

Complies

Identification
Kanamycin Acid Sulfate

A: Kanamycin by TLC
     B: Melting Point about 235°C
     C: Kanamycin by ninhydrin test
     D: Reaction of sulphate

Positive
     Positive
     Positive
     Positive

Pyrogens

Should comply

Complies

Abnormal Toxicity

Should comply

Complies

Specific optical rotation

+103-+115

+108

Loss on drying

≤ 5.0%

3.2%

Sulphate

23.0% ~ 26.0%

25.1%

Sulphate Ash

≤ 0.5%

0.1%

Kanamycin B

≤ 4.0%

2%

pH

5.5 ~ 7.5

6.5

Sterility

Should comply

Complies

Residual Solvent

Ethanol≤ 500ppm

8ppm

Assay
Kanamycin Acid Sulfate

Not less than 670IU/mg

690 IU/mg

Property of Kanamycin acid sulfate, BP

Product Name: Kanamycin acid sulfate, BP

Chemical Name: D-Streptamine, O-3-amino-3-deoxy-.alpha.-D-glucopyranosyl-(1?6)-O-6-amino-6-deoxy-.alpha.-D-glucopyranosyl-(1?4)-2-deoxy-, sulfate (1:2) (salt), Kanamycin acid sulfate

Kanamycin acid sulfate, BP CAS Number: 64013-70-3

Molecular Formula: C18H36N4O11 · 2 H2SO4

Molecular Weight: 680.65 g/mol

Form: Powder

Appearance: Colorless solid

Solubility: Water: Freely soluble

Source: Streptomyces Kanamyceticus

Potency (on a dry basis): 670 IU/mg

Storage Conditions: 2­8 °C

 

Top Quality, China Pure Kanamycin Sulfate, Kanamycin Acid Sulfate Powder/Substance factory in China; China Kanamycin Sulfate, Kanamycin Acid Sulfate Raw Material Supplier in China. China Kanamycin Sulfate, Kanamycin Acid Sulfate API Manufacturer in China. 


Related similar product you may interested:    

Kanamycin Mono Sulfate CAS 25389-94-0

Kanamycin Acid Sulfate CAS 64013-70-3


If you are looking for the kanamycin mono sulfate 25389-94-0 cas and kanamycin acid sulfate cas 64013-70-3, welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.
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