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Ornidazole Powder Raw Material, API BP, EP, USP CAS 16773-42-5

Ornidazole Powder Raw Material, API BP, EP, USP CAS 16773-42-5

China Ornidazole Suppliers, China Ornidazole Manufacturers CAS 16773-42-5 Product Name: Ornidazole Synonyms: Ornidazol, Ornidazolum Chemical Name: 1-(3-Chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole CAS Number: 16773-42-5 Characteristics: White or white yellow crystalline powder,...

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Ornidazole Powder Raw Material, API BP, EP, USP CAS 16773-42-5

Ornidazole Powder Raw Material, API BP, EP, USP.jpg

Product Name:  Ornidazole Raw Material, API BP, EP, USP

Synonyms:  Ornidazol, Ornidazolum

Chemical Name: 1-(3-Chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole

CAS Number: 16773-42-5

Characteristics: White or white yellow crystalline powder, light-sensitive, without smell

Assay:  ≥ 99.0% (Ornidazole, Dried)

KEYWORD: Ornidazole

Formula: C7H10ClN3O3 

Ornidazole Powder Raw Material, API BP, EP, USP formula.jpg

Package: 25Kgs/Drum

Description:

Ornidazole is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria.

It is used against infections. Ornidazole is partially plasma-bound and also has radiation-sensitizing action.

 

Ornidazole Raw Material, API BP, EP, USP is a drug that will help to cure some protozoan infections. It has also been used Ornidazole under some certain conditions in Crohn's disease after bowel resection.

Synthesis of Ornidazole Raw Material, API is a straightforward reaction between 2-methyl-nitroimidazole and epichlorohydrin under acid catalyst conditions.

After passive absorption into bacterium cell, the nitro group of Ornidazole will be reduced to amine group by ferrodoxin type redox system. The formation of redox intermediate intracellular metabolites is believed to be the key component of microorganism killing function for Ornidazole. The drug is active against anaerobic bacteria viz. Peptostreptococcus, Clostridium, B. fragilis, Prevotella, Porphyronomas, Fusobacterium and protozoa viz. E. histolytica, T. vaginalis, G. intestinalis etc.

 

Analysis Data:

HPLC: Shows Min 100.00% purity

H-NMR: Consistent with structure

Specification: Ornidazole is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria

Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.

 

As a professional China Ornidazole Raw Material, API BP, EP, USP supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Ornidazole Raw Material, API BP, EP, USP from China in China for almost 10 years.


Mechanism:

Ornidazole is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.

 

Usage:

-Ornidazole is used to treat trichomonas infections

-Ornidazole will be made into some formulations which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal.

-Ornidazole will be made into drugs that will potentiate the effectiveness of radiation therapy in destroying unwanted cells. 

Shelf life: 3 years.

 

Ornidazole is a 5- nitroimidazole antibiotic, for the treatment of anaerobic bacteria and protozoan, Trichomonas infection.

 

Ornidazole Indications:

1. Ornidazole Raw Material, API  will help to treat Bacteroides fragilis, Dirichlet Bacteroides, oval Bacteroides, Bacteroides thetaiotaomicron, ordinary Bacteroides, Clostridium, Eubacterium, peptococcus and Peptostreptococcus, Helicobacter pylori, the melanin to various bacteria, Clostridium, CO2 bacteriophage fabric bacteria, the gum rod bacteria sensitive anaerobic bacteria caused by infectious diseases, including:

1) abdominal infection: membrane inflammation, intra-abdominal abscess, liver abscess;

2) pelvic infection: endometritis, uterine myositis, tubal or ovarian abscess, pelvic soft tissue infection, Haemophilus vaginitis;

3) oral infection: periodontitis, periapical periodontitis, pericoronitis, acute ulcerative gingivitis;

4) surgical infection: wound infection, skin abscess, decubitus ulcer infection, cellulitis, gas gangrene;

5) brain infection: meningitis, brain abscess;

6), bacteremia, sepsis severe anaerobic bacteria infection.

 

2. Ornidazole Raw Material, API will treat and prevent some infection. 

3  Ornidazole Raw Material, API  will fight against Amiba worm diseases

 

Ornidazole Side effects (Adverse reactions):

Normally speaking, . Ornidazole is usually well tolerated, medication may emerge during the following reaction:

1 For digestive system: There can be side effects like mild stomach upset, nausea, bad breath and so on;

2 For nervous system: After the usage of Ornidazole, there can be unexpected dizziness and drowsiness, etc;

3 Ornidazole may cause allergic reactions: such as rash, pruritus;

4 Ornidazole my be related to neutropenia.


COA of Ornidazole

Name    of Product

Ornidazole

Testing Item

Standard

Result

Appearance

White    or white yellow crystalline powder, light-sensitive, without smell

Complies

Solubility

Soluble    in ethanol, slightly soluble in water

Complies

Identification
 (Ornidazole)

UV: spectrum of absorption of tested solution in    the range at 200 to 340 µm should have maximum at 230±2 µm and 312±2 µm

Complies

IR    spectrum of preparation (prepared as disk using of kalii bromide) in the    range at 400 to 4000cm-1 should have full coincidence of absorption lines of    IR spectrum of standard sample of Ornidazole

Complies

Quality    reaction:
 White    color sediment must appears
 Sediment    is to be insoluble in diluted nitric acid and souble in solution of ammonia.    Yellowish color sediment must appears

Complies

Melting Point

85°C ~ 90°C

87.9°C ~ 89.4°C

Sulphated    ash

≤0.1%

0.05%

Heavy    Metals

≤0.002%

<0.002%

2-Methyl-5-nitroimidazole    (TLC)

≤0.2%

Do not detect

Chloride

≤0.02%

<    0.02%

Sulfates

≤0.025%

<    0.025%

ammonium    salt

≤0.03%

< 0.03%

Loss    on drying

≤0.5%

0.03%

Iron

≤0.002%

< 0.002%

Microbiology

Total    count of aerobic bacteria not more than 103 in 1 g or 1 ml

Complies

Total    count of fungi not more than 102 in 1 g or 1 ml

Complies

Absence    of Escherichia coli in 1 g or 1 ml

Complies

Assay    (Ornidazole)

≥    99.0%

99.98%

 

Top Quality, China Pure  Ornidazole Powder/Substance factory in China;  China Ornidazole Raw Material Supplier in China. China Ornidazole API Manufacturer in China. 


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