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Benzathine Benzylpenicillin Sterile or Penicillin G Benzathine sterile Raw Material, API (CAS 1538-09-6)

Benzathine Benzylpenicillin Sterile or Penicillin G Benzathine sterile Raw Material, API (CAS 1538-09-6)

BBenzathine Benzylpenicillin Sterile or Penicillin G Benzathine sterile Raw Material, API (CAS 1538-09-6) Product Name: Benzathine Benzylpenicillin or Penicillin G Benzathine Synonyms: Benzathine Penicillin, Benzylpenicillin Benzathine, Benzathine Penicillin G; CAS Number: 1538-09-6 Characteristics: White or almost white powder...

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Benzathine Benzylpenicillin Sterile or Penicillin G Benzathine sterile Raw Material, API (CAS 1538-09-6)

Benzathine Penicillin, Benzylpenicillin Benzathine, Benzathine Penicillin G.jpg

Product Name:  Benzathine Benzylpenicillin or Penicillin G Benzathine, Bicillin L-A

Synonyms:  Benzathine Penicillin, Benzylpenicillin Benzathine, Benzathine Penicillin G;

CAS Number: 1538-09-6

Characteristics: White or almost white powder

Assay:  96.0% ~ 102.0% Benzathine Benzylpenicillin

Formula: C48H56N6O8S2

Benzathine Benzylpenicillin Sterile or Penicillin G Benzathine sterile Raw Material, API formula.jpg

KEYWORD: Benzathine Penicillin, Benzathine Benzylpenicillin, Penicillin G Benzathine, Benzylpenicillin Benzathine,  Benzathine Penicillin G, Bicillin L-A

Standard: EP, BP

Package: 20BOU/Drum

 

Description:

Benzathine Benzylpenicillin or Penicillin G Benzathine Sterile powder is a Semisynthetic antibiotic prepared by combining the sodium salt of penicillin G with N,N'-dibenzylethylenediamine.

Benzathine Benzylpenicillin or Penicillin G Benzathine Sterile powder is a natural substance/API derived from Penicillium notatum. Benzathine Penicillin G consists of a thiazolidone ring connected to a beta-lactam ring. With its bactericidal ability, against streptococci, neisseriae and many anaerobes, Benzathine Benzylpenicillin or Penicillin G Benzathine Sterile powder has many popular usage in pharmaceutical industry.

Benzathine Benzylpenicillin sterile powder raw material, API is a form of penicillin also known as benzathine penicillin. It is an antibiotic useful for the treatment of a number of bacterial infections. It is on the World Health Organization's List of Essential Medicines.

 

Penicillin G Benzathine (Benzathine Penicillin G) sterile powder raw material, API is used when low concentrations of Benzylepenicillin are required over a long period of time.

This antibiotic, Benzathine Benzylpenicillin or Penicillin G Benzathine sterile powder raw material, API, can remain active for 2- weeks after a single IM dose. , Benzylpenicillin Benzathine/ Benzathine Benzylpenicillin sterile powder raw material, API is used to treat severe infections such as strep, meningitis, diphtheria, staph infections, etc.

 

After Penicillin G Benzathine (Benzathine Penicillin G) intramuscular injection, peak plasma concentrations are usually reached within 0.5 to 1 day. And Benzathine Benzylpenicillin will be still detectable for 7~28 days. It will be widely distributed throughout our body and it will be excreted mainly in the urine.

 

Penicillin G Benzathine (Benzathine Penicillin G) is a penicillin antibiotic which can be given by deep intramuscular injection. Penicillin G benzathine will eliminate the susceptible bacteria by inhibiting the synthesis or formation of bacterial cell wall. It is believed to preferentially bind to specific penicillin-binding proteins found inside the bacterial cell wall. The final result of the inhibition of bacterial cell synthesis is cell lysis and the death of the susceptible bacteria.

 

Penicillin G benzathine has poor solubility. So, it will be slowly released from the site of injection. In the blood, penicillin G benzathine will be broken down to penicillin G. Penicillin G benzathine formulation is released and absorbed slowly. This property will ensure there can be a prolonged duration.

 

As a professional China Penicillin G Benzathine(Benzathine Penicillin G) sterile powder Raw Material supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Penicillin G Benzathine(Benzathine Penicillin G) sterile powder API from China in China for almost 10 years.


Usage:

Benzylpenicillin Benzathine sterile powder raw material, API will that inhibit the growth or reproduction of bacteria (especially Streptococcal pharyngitis). It is the API of the final drug.

It will help in for treating Primary and secondary prophylaxis of rheumatic fever.

 

Formulation in the market:

Benzathine Benzlypenicillin (Benzathine Penicillin) Powder for Injection

 

Benzathine Benzlypenicillin (Benzathine Penicillin) side effects:

Although Benzathine Benzylpenicillin or Penicillin G Benzathine Sterile powder is  a very effective substance, there still can be some unwanted side effects such as:

fatigue, headache, nervousness, pain, seizures, weakness, injection site reactions, blurred vision,

hypersensitivity or allergic reactions, stomach disorders, neuropathy, dizziness, sexual dysfunction,

kidney problems, etc.

 

Benzathine Benzlypenicillin (Benzathine Penicillin) Drug-interactions:

-Penicillin G benzathine may decrease the renal tubular secretion (elimination via the kidneys) of methotrexate (Trexall, Rheumatrex) causing an increase in blood levels of methotrexate. Patients on combination therapy should be closely supervised.

-Moreover, Penicillin G benzathine may interfere with the body's response to the live typhoid vaccine. This vaccine should be used after at least 1 whole day after the application of Benzathine Benzlypenicillin (Benzathine Penicillin).

-Penicillin G benzathine may affect oral contraceptives functions.  There should be backup method of contraceptive while under Benzathine Benzlypenicillin (Benzathine Penicillin)  treatment.

-  Co-Administration of Benzathine Benzlypenicillin (Benzathine Penicillin) with warfarin will lead to a higher bleeding risk. It will inhibit vitamin K synthesis. For safety, those who are in combination medicine treatment should be carefully monitored.

 

Penicillin G benzathine will be excreted in human milk. It should be used cautiously in females who are breastfeeding.


COA of Benzathine Benzylpenicillin sterile powder raw material, API

Product

Benzathine    Benzylpenicillin (Sterile)

Testing Item

Standard

Result

Appearance

White    or almost white powder

Complies

Identification

IR    spectrum complies with that of reference standard (IR)
 Benzathine    Benzylpenicillin

Complies

Acidity    or alkalinity

≤    0.2ml

0.1ml

Sterility

Should    comply

Complies

Bacterial    Endotoxins

<    0.13 IU/ml

<    0.13 IU/ml

Moisture

5.0%~8.0%

6.8%

Residual    Solvents

Ethyl    Acetate: ≤ 5000ppm

80ppm

Methanol:    ≤ 3000ppm

19ppm

Related    substances(HPLC)

Impurity C: ≤2.0%
 Not    more than the sum of the areas of the 2 principal peaks

0.412%

Other impurity: ≤1.0%
 Not    more than the sum of the areas of the 2 principal peaks

0.125%

N,N-dibenzylethylenediamine    Benzathine (HPLC)

24.0%    ~ 27.0%
 (Anhydrous    Basis)

26.2%

Benzathine    Benzylpenicillin (HPLC)

96.0%    ~ 102.0%
 (Anhydrous    Basis)

100.1%

Benzathine Benzylpenicillin sterile powder raw material, API has many names like Benzathine Penicillin, Benzathine Benzylpenicillin, Penicillin G Benzathine, Benzylpenicillin Benzathine, , Benzathine Penicillin G, Bicillin L-A

 

Top Quality, China Pure Benzathine Benzylpenicillin, Bicillin L-A, Penicillin G Benzathine Powder/Substance factory in China;  Benzathine Benzylpenicillin, Bicillin L-A, Penicillin G Benzathine Raw Material Supplier in China. China Benzathine Benzylpenicillin, Bicillin L-A, Penicillin G Benzathine API Manufacturer in China. 


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Benzathine Benzylpenicillin Sterile Or Penicillin G Benzathine Sterile Raw Material, API (CAS 1538-09-6)

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