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Analgin or Metamizole Sodium or Dipyrone CAS 68-89-3

Analgin or Metamizole Sodium or Dipyrone CAS 68-89-3

Analgin or Metamizole Sodium or Dipyrone CAS 68-89-3 Product Name: Analgin (Metamizole Sodium) Synonyms: Dipyrone, Metamizolum natricum CAS Number: 68-89-3 or 5907-38-0 Characteristics: A white or almost white crystalline powder Solubility: Analgin (Metamizole Sodium) is Soluble in alcohol and...

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Analgin or Metamizole Sodium or Dipyrone CAS 68-89-3                                              Analgin or Metamizole Sodium or Dipyrone API picture.jpg

Product Name:  Analgin (Metamizole Sodium)

Synonyms: Dipyrone, Metamizolum natricum

CAS Number: 68-89-3 or 5907-38-0

Characteristics:  A white or almost white crystalline powder

Solubility: Analgin (Metamizole Sodium) is Soluble in alcohol and very soluble in water.

Content:  99%~100.5%

Standard: DAB10, EP, BP, CP

Formula:   C13H16N3NaO4S,H2O

Analgin or Metamizole Sodium or Dipyrone formula.jpg

Storage conditions:  Sealed container.

Package: 25Kg/Fiber Drum 

Description:

Metamizole sodium, also called Analgin widely, is a non-steroidal anti-inflammatory drug, with the chemical name Sodium [(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4- yl)-N-methylamino]methanesulfonate monohydrate.  Metamizole sodium or Analgin is commonly used in many countries as a powerful painkiller and fever reducer. It is also known under the names Dipyrone, Analgin, Novalgin, and Melubrin.

Metamizole sodium or Analgin raw material was discovered that it carries a very small risk of causing agranulocytosis, which is a dangerous and potentially fatal condition. Controversy remains regarding the level of risk till now. 

Compared with Pracetamol and Ibuprofen, Metamizole Sodium or Analgin raw material is a relatively more effective antipyretic (fever reducer) and analgesic (pain reliever). Analgin or Metamizole sodium produced a significantly greater temperature reduction than ibuprofen. It will make the low temperatures longer.

Metamizole Sodium or Analgin is used in treating moderate and severe pain including, toothaches, visceral pain, headaches, acute injury, and some other  acute/chronic pain. And it also have the power to relieve high fever. In some other occasions like severe pain associated with surgeries, cancer or stomach problems, Metamizole Sodium or Analgin raw material will also play a good role.

 

As a professional China Metamizole Sodium, Analgin, Dipyrone Raw Material supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Metamizole Sodium, Analgin, Dipyrone API from China for almost 10 years.


Application:

Analgin is also know as Metamizole Sodium or Dipyrone. It is Antipyretic analgesics of Pyrazolones. Analgin (Metamizole Sodium) indicated for treatment diseases caused by high fever and various pain. It is also indicated in fever, headache, rheumatic pain, neuralgia and dysmenorrheal, etc. 

Usage: Analgin is also called Metamizole Sodium, Dipyrone.  There are injection grade and oral grade for Analgin. Analgin (Metamizole Sodium) is one of the safest Analgesic-Antipyretic substance.  The preparations in the markets are like Metamizole Sodium Injection, Metamizole Sodium Tablet, etc.

Analgin (Metamizole Sodium) are used to treat a number of ailments like toothaches and headaches, joints pain, muscle pain, and never pains.  

 

Indications:

Metamizole Sodium or Analgin are widely given by the doctores to treat pains pains of various origin:

milder visceral pains, arthralgia, neuralgia, myalgia, etc.

Metamizole Sodium or Analgin also works as an antipyretic in the complex therapy of inflammatory diseases of upper respiratory tract, infectious diseases.

Injection grade Analgin or Metamizol is used by injections to treat severe pains after surgical operations or other traumas, tumor caused pains, etc.

 

Mechanism of Action of Analgin or metamizole sodium

Analgin or metamizole sodium is a active pharmaceutical ingredient belongs to the pyrazolone group, which has analgesic and antipyretic properties and moderate antiinflammatory activity. Analgin or metamizole sodium will block synthesis of endogenous pyrogens - prostaglandins D and E. In contrast to the other nonnarcotic analgesic drugs, Analgin or metamizole sodium stimulates the release of β-endorphins, which is the very reason for its activity in cases of visceral pain. Analgin or metamizole sodium has a slight spasmolytic activity on the smooth muscle cells of the biliary and urinary tracts and also on the muscle of the uterus.

 

Foreign Names of metamizole sodium:

Metamizolum (Latin) Sodium

Metamizol (German)

Métamizole (French)

Metamizol (Spanish)

 

Analgin Side Effects:

Metamizole sodium or Analgin has a potential of haematologic toxicity, although the chances is very slim. Metamizole sodium may also trigger bronchospasm or anaphylaxis, especially in those with asthma.

After a long time or longer than normal administration of Metamizole sodium or Analgin, there very rarely can be observed agranulocytosis, leucopenia and thrombocytopenia, proteinuria, interstitial nephritis. For some certain patients, rashes, asthmatic attacks, and very rarely anaphylactic shock can be the adverse effect.

 

Metamizole or Analgin Drug interactions:

The enzyme inductors, such as glutethimide, may reduce Metamizole Sodium effects. Analgin may also potentiate the CNS-inhibiting agent’s effects. There can be a risk of severe hypothermia if Metamizole sodium or Analgin is used in conjunction with chlorpromazine. 


Certificate of Analysis-- Analgin (Metamizole Sodium)

Items

Specifications

Result

Appearance

Analgin

An   almost white crystalline powder

Pass

Identification

Analgin   (Metamizole Sodium)

1)        Infrared spectrum

 comply with the reference.

2)  the color is from blue to dark red

3)  color bluish violet

4)  examine0.5gtestanalgin,

Sodium   can be identified.

Positive   reaction

Clarity&   color of solution

Dab10/ep5

Suspension   i   by6

Acidity   or alkalinity

Dab10/ep5

 

0.1ml

Related   substances (hplc)

Impurity   c≤0.5%

Total   impurities ≤0.5%

Any   individual impurity except c≤0.2%

 

Pass

Sulphate

≤0.1%

0.1%

Solvent   residues(ethanol)

Not   more than 5000ppm

<100ppm

Heavy   metal

≤20ppm

10ppm

Loss   on drying

 

4.9%~5.3%

5.1%

Assay   (on the dried basis)

99%~100.5%

Analgin   (Metamizole Sodium)

99.2%

 Top Quality, Pure Analgin (Metamizole Sodium) Powder;  Analgin (Metamizole Sodium) Raw Material Supplier in China. Analgin (Metamizole Sodium) API Manufacturer. 


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7. Diclofenac Sodium CAS 15307-79-6



If you are looking for the analgin or metamizole sodium or dipyrone cas 68-89-3, welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.

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