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Trimethoprim Lactate, Trimethoprim Mechanism of Action

Fengchen Group Co.,Ltd | Updated: Aug 13, 2017

Trimethoprim Lactate, Trimethoprim Mechanism of Action

Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim's affinity for bacterial dihydrofolate reductase is several thousand times greater than its affinity for human dihydrofolate reductase. Sulfamethoxazole inhibits dihydrofolate synthetase (aka dihydropteroate synthetase), an enzyme involved further upstream in the same pathway. Trimethoprim and sulfamethoxazole are commonly used in combination due to their synergistic effects. This drug combination also reduces the development of resistance that is seen when either drug is used alone.

 

Chemical Name of Trimethoprim

5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine

Structure formular:
COC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1OC

10%~20% percent of trimethoprim is metabolized, primarily in the liver; the remainder is excreted unchanged in the urine. After oral administration, 50% to 60% of trimethoprim is excreted in the urine within 24 hours, approximately 80% of this being unmetabolized trimethoprim. Trimethoprim also passes the placental barrier and is excreted in human milk.

 

Drug Interactions: 

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Please see our detailed product information as following: 

Trimethoprim and Trimethoprim Lactate

http://www.fengchengroup.com/pharmaceutical-api/antibiotics/trimethoprim-cas-738-70-5-and-trimethoprim.html




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Skype: frankrenful2002
E-Mail: frank_feng@fengchengroup.com
Tel: +86-186-7846 1007
WECHAT: +86-18678461007
WHATSAPP: +86-18678461007
Add: Room 1101, 5th Building, No.168 Shenzhen Road, Qingdao, China
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