Gentamycin Sulfate Technical Data Sheet
Gentamycin Sulfate Indications:
Bacterial infections caused by susceptible pathogens especially gm-ve bacilli.
Gentamicin Sulfate is an aminoglycoside antibiotic, used to treat many types of bacterial infections, particularly those caused by Gram-negative bacteria. However, Gentamicin Sulfate is not used for Neisseria gonorrhoeae, Neisseria meningitidis or Legionella pneumophila bacterial infections (because of the risk of the patient going into shock from lipid A endotoxin found in certain gram negative organisms). Gentamicin Sulfate is one of the few heat-stable antibiotics that remain active even after autoclaving, which makes it particularly useful in the preparation of certain microbiological growth media. Treatment of susceptible bacterial infections, normally Gram-negative bacteria including Pseudomonas, Proteus, Serratia, and Gram-positive Staphylococcus. Gentamicin Sulfate is the only heat-stable antibiotic, hence its use during orthopaedic surgery when high temperatures are required for the setting of cements (e.g. hip replacements)
Gentamycin sulfate contraindications
-Hypersensitivity to aminoglycosides.
If there is a pregnancy, important things to know about Gentamycin Sulfate:
There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Gentamycin Sulfate using Guide:
Children: Use Gentamycin Sulfate cautiously in premature infants and neonates because of renal immaturity. Elderly or debilitated patients: Drug levels and renal function must be monitored closely. Burn patients: Pharmacokinetics may be altered; serum levels must be closely monitored for dosing. Hypomagnesemia: Occur often, especially in those with restricted diets or poor nutrition. Neuromuscular blockade: Potential curare-like effects may aggravate muscle weakness or cause neurotoxicity. Use Gentamycin Sulfate with caution with anesthesia or muscle relaxants; in patients with neuromuscular disorders, hypomagnesemia, hypocalcemia and hypokalemia; and in neonates whose mothers received magnesium sulfate. Sulfite sensitivity: Some products contain sulfites. Do not use Gentamycin Sulfate if there is history of hypersensitivity. Toxicity: Drug is associated with significant nephrotoxicity and ototoxicity. Use Gentamycin Sulfate with particular caution in patients with renal impairment and elderly patients.
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