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L-Serine Powder API Raw Material CAS 56-45-1

L-Serine Powder API Raw Material CAS 56-45-1

Product Name: L-Serine Powder API Raw Material CAS 56-45-1 Characteristics: White crystals or crystalline powder Assay: 99.0% to 101.0% L-Serine Formula: C3H7NO3 Structure Formula: KEY Words: L-Serine, Serine Package: 25Kgs/Drum Standard: USP, AJI92 Description: L-serine is a non-essential amino acid. It is...

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L-Serine Powder API Raw Material CAS 56-45-1

L-Serine Powder API Raw Material.jpg

Product Name: L-Serine

CAS Number: 56-45-1

Characteristics:  White crystals or crystalline powder

Assay: 99.0% to 101.0% L-Serine

Formula:  C3H7NO3

Structure Formula: 

L-Serine Powder API Raw Material formula.jpg

KEY Words: L-Serine, Serine Powder API Raw Material USP, AJI92

Package: 25Kgs/Drum

Standard: USP, AJI92

Description:

L-serine is a non-essential amino acid. It is found in eggs, fish, soybeans. The human body can also synthesize L-Serine itself. It is synthesized from glycine or threonine. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.

L-Serine is present and functionally important in many proteins. With an alcohol group, L-serine is needed for the metabolism of fats, fatty acids, and cell membranes; muscle growth; and a healthy immune system. It also plays an important role in pyrimidine, purine, creatine, and porphyrin biosynthetic pathways. 

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L-Serine, Serine Powder API Raw Material USP, AJI92 is considered to be a non-essential amino acid. In reality, it is formed from another amino acid named Glycine.  Both mentally and physically speaking, L-Serine, Serine Powder API Raw Material USP, AJI92 is important crucial. It plays key role in making central nervous system and the brain function correctly and normally.

 

L-Serine, Serine Powder API Raw Material USP, AJI92 is also involved in the formation of phospholipids needed for cell production. L-Serine, Serine Powder API Raw Material USP, AJI92 help to maintain the normal functions of DNA and RNA, muscle formation, and metabolism of fat and fatty acids.

By the way, Anti-bodies and immunoglobulins also require L-Serine, Serine Powder API Raw Material USP, AJI92 to support a healthy immune system.

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L-Serine, Serine Powder API Raw Material USP, AJI92 is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated - form under biological conditions), a carboxyl group (which is in the deprotonated - form in physiological conditions), and a side chain consisting of a hydroxymethyl group (see hydroxyl), classifying L-Serine, Serine Powder API Raw Material USP, AJI92 as a polar amino acid. Technically, L-Serine, Serine Powder API Raw Material USP, AJI92I is able to be synthesized in the human system under normal physiological circumstances, making it a nonessential amino acid.

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L-Serine, Serine Powder API Raw Material USP, AJI92 is an α-amino acid which is common in many proteins, sometimes in substantial concentrations in the outer regions of soluble proteins due to its hydrophilic nature. L-Serine, Serine Powder API Raw Material USP, AJI92 is an important component of phospholipids and participates in the biosynthesis of purines and pyrimidines, as well as such amino acids as cysteine and glycine. With an easily removed hydrogen on the hydroxyl side chain, L-Serine, Serine Powder API Raw Material USP, AJI92 is a hydrogen donor in enzymes, like trypsin and chymotrypsin, functioning as catalysts.

In humans, the L-isomer, which is the only form that is involved in protein synthesis, is one of the 20 standard amino acids required for normal functioning. However, L-Serine, Serine Powder API Raw Material USP, AJI92 is considered to be a "non-essential" amino acid because it does not have to be taken in with the diet, but can be synthesized by the human body from other compounds through chemical reactions.

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As a professional China L-serine supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting L-Serine, Serine Powder API Raw Material USP, AJI92 from China for almost 10 years. 


Like all the amino acid building blocks of protein and peptides, L-serine can become essential under certain conditions, and is thus important in maintaining health and preventing diseases. Low-average concentration of serine compared to other amino acids is found in muscle. L-Serine is highly concentrated in all cell membranes. 

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Synthesis and industrial production:

L-Serine, Serine Powder API Raw Material USP, AJI92 is produced by fermentation, with an estimated 100-1000 tons per year produced.

 

 

Biological function:

-Metabolic:

L-Serine, Serine Powder API Raw Material USP, AJI92 is important in metabolism because it participates in the biosynthesis of purines and pyrimidines. It is the precursor to many amino acids like glycine and cysteine, as well as tryptophan in bacteria. L-Serine, Serine Powder API Raw Material USP, AJI92 is also the precursor to numerous other metabolites, like sphingolipids and folate, which is the principal donor of one-carbon fragments in biosynthesis.

 

-Structural role:

L-Serine, Serine Powder API Raw Material USP, AJI92 is crucial in the catalytic function of several enzymes. L-Serine, Serine Powder API Raw Material USP, AJI92 has been proven to exist in the active sites of chymotrypsin, trypsin, and many other enzymes. The so-called nerve gases and many substances used in insecticides have been shown to act by combining with a residue of serine in the active site of acetylcholine esterase, inhibiting the enzyme completely.

 

L-Serine, Serine Powder API Raw Material USP, AJI92 side chains are often hydrogen bonded; the commonest small motifs formed are ST turns, ST motifs (often at the beginning of alpha helices) and ST staples (usually at the middle of alpha helices).

As a constituent of proteins, its side chain can undergo O-linked glycosylation, which may be functionally related to diabetes.

L-Serine, Serine Powder API Raw Material USP, AJI92 is one of 3 amino acid residues which are normally phosphorylated by kinases during cell signaling in eukaryotes. Phosphorylated serine residues are often referred to as phosphoserine. Serine proteases are a common type of protease.

 

-Clinical significance:

L-Serine, Serine Powder API Raw Material USP, AJI92 deficiency disorders are rare defects in the biosynthesis of the amino acid L-serine. Now, 3 disorders have been reported: 3-phosphoglycerate dehydrogenase deficiency, 3-phosphoserine phosphatase deficiency and Phosphoserine aminotransferase deficiency. These enzyme defects will cause severe neurological symptoms like congenital microcephaly and severe psychomotor retardation and in addition in patients with 3-phosphoglycerate dehydrogenase deficiency to intractable seizures. The above problems respond to a variable degree to treatment with L-Serine, Serine Powder API Raw Material USP, AJI92, sometimes together with glycine. Response to treatment is variable and the long-term and functional outcome is unknown. To provide a basis for improving the understanding of the epidemiology, genotype/phenotype correlation and outcome of these diseases their impact on the quality of life of patients, as well as for evaluating diagnostic and therapeutic strategies a patient registry was established by the noncommercial International Working Group on Neurotransmitter Related Disorders.

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Biosynthesis

L-Serine, Serine Powder API Raw Material USP, AJI92 is not essential to the human diet, because it can be synthesized in the body. The synthesis of L-Serine, Serine Powder API Raw Material USP, AJI92 starts with the oxidation of 3-phosphoglycerate forming 3-phosphohydroxypyruvate and NADH. Reductive amination of this ketone followed by hydrolysis yields serine.

 

L-Serine, Serine Powder API Raw Material USP, AJI92 also gives rise to the amino acid glycine, thus glycine is not classified as an essential amino acid. The enzyme serine hydroxymethyl transferase catalyzes this reversible, simultaneous conversions of L-serine to glycine (retro-aldol cleavage) and 5,6,7,8-tetrahydrofolate to 5,10-methylenetetrahydrofolate (hydrolysis) (Lehninger 2000). The conversion of L-Serine, Serine Powder API Raw Material USP, AJI92 to glycine is characterized as follows:

HO2C-CH(NH2)-CH2-OH (serine) + H2folate → HO2CCH2NH2 (glycine) + CH2-folate + H2O

That is to say, L-Serine, Serine Powder API Raw Material USP, AJI92 is prepared commercially from methyl acrylate.

 

Function:

L-Serine, Serine Powder API Raw Material USP, AJI92 plays a role in the biosynthesis of proteins, phospholipids, purines, pyrimidines, the amino acids cysteine and glycine, and many other biologically important compounds. L-Serine, Serine Powder API Raw Material USP, AJI92 is also the precursor to numerous of other metabolites, including sphingolipids and folate, which is the principal donor of one carbon fragments in biosynthesis.

Like cysteine, L-Serine, Serine Powder API Raw Material USP, AJI92 often helps an enzyme catalyze its reaction, occuring in the active sites of such enzymes as trypsin (a serine protease found in the digestive system, where it breaks down proteins) and chymotrypsin (a digestive enzyme that can perform proteolysis, cleaving peptides at the carboxyl side of tyrosine, tryptophan, and phenylalanine).

 

As a constituent of proteins, side chain of L-Serine, Serine Powder API Raw Material USP, AJI92 could undergo O-linked glycosylation. This can be important in explaining some of the devastating consequences of diabetes. It is one of three amino acid residues that are commonly phosphorylated by kinases during cell signaling in eukaryotes. Phosphorylated serine residues are often referred to as phosphoserine. Serine proteases, such as trypsin, are a common type of protease.

 

The important role of L-Serine, Serine Powder API Raw Material USP, AJI92 in the active site of acetylcholine esterase has been exploited in the production of nerve gases, like Sarin, and insecticides. Acetylcholine is a small organic molecule that serves as an important neurotransmitter, relaying information across the gap (synapse) between a neuron (nerve cell) and an adjacent cell (another neuron or a muscle or gland cell). After acetylcholine has completed its role of transmitting the message (for the electrical impulse to continue in the adjacent neuron, or the muscle cell to contract, or the gland to secrete), it must be removed so that it does not keep stimulating the receptor cell. The enzyme acetylcholine esterase fulfills this function, converting acetylcholine into the inactive metabolites choline and acetate and clearing free acetylcholine from the synapse. It is a fast enzyme that can rapidly hydrolyze acetylcholine 10,000 molecules of acetylcholine can be hydrolyzed in one second by one molecule of this enzyme.

However, Sarin and other nerve gases combine with a residue of L-Serine, Serine Powder API Raw Material USP, AJI92 in the active site and cause irreversible inactivation of this enzyme. The resulting accumulation of acetylcholine causes continuous stimulation of the muscles, glands, and the central nervous system; victims commonly die of suffocation as they cannot contract their diaphragm. Other organophosphates and some carbamates are effective insecticides because they inhibit acetylcholinesterase in insects.

D-serine, synthesized by serine racemase from L-Serine, Serine Powder API Raw Material USP, AJI92, acts as a neuronal signaling molecule by activating NMDA receptors in the brain.

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COA of L-Serine:

L-Serine Powder API Raw Material COA.jpg

Top Quality, China Pure L-Serine, Serine Powder API Raw Material USP, AJI92 Substance factory in China; China L-Serine, Serine Powder API Raw Material USP, AJI92 Suppliers in China. China L-Serine, Serine Powder API Raw Material USP, AJI92 Manufacturers in China. 

If you are looking for the L-Serine Powder API Raw Material CAS 56-45-1, welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.
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