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Dextran 40 and Dextran 20, Dextran 70 Raw Material API for Injection BP, EP, USP CAS 9004-54-0

Dextran 40 and Dextran 20, Dextran 70 Raw Material API for Injection BP, EP, USP CAS 9004-54-0

Dextran 40 and Dextran 20, Dextran 70 Raw Material API for Injection BP, EP, USP CAS 9004-54-0 Package: 25Kgs/Drum Description & Uses: Dextran 70, Dextran 40, Dextran 20 for Injection are dextran products. Traditionally, Dextrans are used in fluid form. Still, Dextran has a very diverse application area. For example in Vaccines,...

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Dextran 40 and Dextran 20 for Injection CAS 9004-54-0

Dextran 70 Dextran 40  Dextran 20.jpg

Product   Name:

Dextran 70 for injection

Dextran 40 for injection

Dextran 20

Synonyms:  

1.      Dextranum 70 ad iniectabile,

2.      Dextran 70 injectable

3.      Dextranum 40 ad iniectabile,

Dextran   40 injectable

4.    Dextranum   20 ad iniectabile,

Dextran   20 injectable

Characteristics:

White   powder

White   powder

White   odorless powder

CAS   Number:

9004-54-0

Formula:

[C6H10O5]n

Grade   Types:

Dextran   70, Dextran 40, Dextran 20 for Injection

Dextranum (Dextran70, Dextran40, Dextran20, Dextran10) oral grade

Package: 25Kgs/Drum

Description & Uses: Dextran 70, Dextran 40, Dextran 20 for Injection are dextran products. Traditionally, Dextrans are used in fluid form. Still, Dextran has a very diverse application area. For example in  Vaccines, Eye Drops, some times as stabilizer in biological products, or as excipient for the final medicine. It also increases blood sugar level.

Dextran 40 is sterile. And usually it is administered in the form of intravenous infusion.

So is Dextran 70. Almost the same use.

Keywords: Dextran 70, Dextran 40, Dextran 20

 

Description of Dextran.

Dextran 70, Dextran 40, Dextran 20 BP, EP, USP are complex branched glucan composed of chains of varying lengths. This characteristic branching is a property of dextran differs from a dextrin.

Side effects:

There is really few or can even say no Dextran related side effects. Very few of them have been reported.

 

As a professional China Dextran 70, Dextran 40, Dextran 20 Raw Material supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Dextran 70, Dextran 40, Dextran 20 API from China in China for almost 10 years.

 

Uses and applications:

Dextran 70, Dextran 40, Dextran 20 pharmaceutical Grade BP, EP, USP are used commonly by microsurgeons to decrease vascular thrombosis. Till now, no difference has been found in antithrombotic effectiveness in comparison of intra-arterial and intravenous administration of dextran.

 

Pharma Grade Dextrans BP EP USP are available in multiple molecular weights ranging from 3,000 Da to 2,000,000 Da. The larger dextrans (>60,000 Da) can only be excreted poorly from the kidney. It will remain in the blood for weeks until they are metabolized. Consequently, Pharma Grade Dextran 70, Dextran 40, Dextran 20 have prolonged antithrombotic and colloidal effects. In this family, dextran-40 (MW: 40,000 Da), has been the most popular dextran for anticoagulation therapy. About seventy percents of dextran-40 is excreted in urine within the first 1 day after intravenous infusion, while the other thirty percents are retained for more longer time.

 

Other medical uses:

Sometimes as a lubricant, Dextran 70, Dextran 40, Dextran 20 Pharmaceutical Grade will be used in some eye drops. In certain intravenous fluids, Dextran 70, Dextran 40, Dextran 20 Raw Material API may help to solubilize other factors, such as iron. The most famous one is Iron Dextran Solution 10% and 20%.

With Dextran 70, Dextran 40, Dextran 20 Raw Material API Powder in Intravenous solutions, it will work both as volume expanders and parenteral nutrition means. Such a solution will be a good osmotically neutral fluid which once in our body is digested by cells into glucose and free water. For emergencies when there is not enough blood in hospital, this application will help to replace lost blood. Anyhow, special attention and expert skills is needed because it does not provide necessary electrolytes and can cause hyponatremia or other electrolyte disturbances. It has to be under professional guidance.

Dextran 70, Dextran 40, Dextran 20 Pharmaceutical Grade may also rise the blood sugar levels.

 

Laboratory uses:

- Pure Dextran 70, Dextran 40, Dextran 20 Powder is used in the osmotic stress technique for applying osmotic pressure to biological molecules.

- Dextran series products have been used in bead form to aid in bioreactor applications.

- Pure Dextran 70, Dextran 40, Dextran 20 powder are also utilized in immobilization in biosensors.

- Dextran 70, Dextran 40, Dextran 20 can be applied as a stabilizing coating for the protection of metal nanoparticles from oxidation and contribute to improve bio-compatibility.

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Main Indexes –Dextran 40 for Injection   

Dextran 40 and Dextran 20, Dextran 70 Raw Material API for Injection BP, EP, USP TDS.jpg

 

Specification (CP 2015 Standard):

Items

Quality

Characters

Dextran 40

White     powder, tasteless and odourless, easily soluble in hot water, insoluble in     ethanol.

Specific   Optical Rotation

+190°   ~ +200°

Identification

Dextran 40

Should   be positive

Chloride

≤0.25%

Nitrogen

≤0.007%

Loss   on drying

 ≤5.0%

Residue   on ignition

 ≤0.5% 

Heavy   Metals

 ≤0.0008%

Molecular-Mass   Distribution

 3200042000

 ≤120000

 ≥5000

 

Specification (EP 8.0 Standard):

Items

Quality

Molecular weight

35000~45000

Molecular weight   distribution

M10 ≤110000

M90 ≥7000

Solubility

Very soluble in   water, very slightly in alcohol, Clear   and colorless solution

Identification

Dextran


Specific optical   rotation

+195.0~+201.0°

Infrared absorption   spectrogram

Comparing with the   spectrum obtained from dextran CRS

Acidity /   alkalinity

Reaction with   phenolphthalein ,NaOH and HCl

Nitrogen

≤110ppm

Residual solvents


Ethanol

≤0.5%

Methanol

≤0.05%

Other

≤0.5%

Heavy metals

≤10ppm

Loss on drying

≤7.0%

Sulphated ash

≤0.3%

Bacterial   endotoxins

<10 IU/g

Total viable   aerobic

≤100 CFU/g

No colibacillus

Not detected

Appearance

Dextran

White powder

 

Application of Pharma Grade Dextran 40 Powder:

It is mainly used to the production of Pharma Grade Dextran 40 Powder injections and solutions, compound dextran injection and other dextran derivative. Dextran 40 Pharmaceutical Grade Powder can also be used as fillers and excipients in lyophilized powder preparation.  

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Main Indexes –Dextran 20 

Name   of Product

Dextran 20

Testing Item

Standard

Result

Appearance of Dextran 20

White odorless powder

White   odorless powder

Optical   Rotation

+190°~+200°

+192.7°

Chloride

≤0.25%

<0.15%

Limit   of Nitrogenous Impurities

≤0.007%

<0.005%

Loss   on drying

Dextran 20

≤5.0%

3.5%

Sulphated   Ash

≤0.5%

0.32%

Heavy   metal

Dextran 20

≤8ppm

<8ppm

Mass   MW

16000~24000

16738

10%   High molecular Mass MW

≤70000

47487

10%   High molecular Mass MW

≥3500

2028

Confirm the Standard of Dextran 20. 


Other information:

Drug Name: Dextranum (Dextran70, Dextran40, Dextran20, Dextran10, and other specifications

English Name: Dextranum

CAS Number9004-54-0

Dextranum (Dextran70, Dextran40, Dextran20, Dextran10) is derived by controlled hydrolysis and fractionation of polysaccharides elaborated by the fermentative action of certain appropriate strains of Leuconostoc mesenteroides (NRRL, B-512F; NCTC, 10817) on a sucrose substrate. Dextranum (Dextran70, Dextran40, Dextran20, Dextran10) is a glucose polymer in which the linkages between glucose units are almost entirely of the α-1:6 type. Its weight average molecular weight is in the 63,000 to 77,000 range.

 

The use of Dextranum

1.Therapeutic drugs

Dextranum (Dextran70, Dextran40, Dextran20, Dextran10)is a therapeutic drug. "Chinese Pharmacopoeia" column are the molecules (dextranum 70), low molecular weight (dextranum 40), small molecules (dextranum 20) three size varieties. "USP" and "British Pharmacopoeia" column has dextran 70, dextran 60, dextran 40 three varieties. Dextran 70 is mainly used for the generation of plasma, and other specifications dextran used in the clinical improvement of microcirculation and prevention of thrombosis. Preparations are large infusion.

2.Pharmaceutical excipient

High, medium and low molecular weight (molecular weight of 4 ~ 15 × 104) of the dextran can be used for sustained release formulations, targeting formulations reinforcing material. After the isotope-labeled for diagnostic purposes, low and small molecules can be used as granule filler. Micro-molecular dextran materials are used for iron dextran molecular. Molecular weight of thousands of products and other materials are acted as the microcapsule.

2.Food industry

Dextranum (Dextran70, Dextran40, Dextran20, Dextran10) can also be used as food additive, because of its non-toxic without being absorbed by the stomach, it is used as low-energy food filler.

3.Cosmetics Industry

Dextranum (Dextran70, Dextran40, Dextran20, Dextran10) may also be used as a thickener, such as inert filler.

4.A film industry

Dextran derivatives in combination with sulfur can increase the degree of photographic film developing (sharpness increase several times over).

5.Chemical reagents

For the preparation of high molecular weight dextran dextran gel.

FENGCHEN GROUP CO., LTD. has the international advanced production line separation and extraction of fermentation. It can effectively remove dissolved completely under pyrogen and microbial products at room temperature. The main equipment of use computer control to ensure product quality and uniformity and stability. Dextranum (Dextran70, Dextran40, Dextran20, Dextran10) quality meet Chinese Pharmacopoeia, British Pharmacopoeia ,United States Pharmacopoeia (BP, USP, CP).

Product specifications have 10kg, 25 kg of aluminum foil composite film bags or cardboard lined with special plastic bag, sealed storage, valid for two years.


Top Quality, China Pure Dextran 70, Dextran 40, Dextran 20 Powder factory in China; China Dextran 70, Dextran 40, Dextran 20 Raw Material Suppliers in China. China Dextran 70, Dextran 40, Dextran 20 API Manufacturers in China. 


Related products you may interested in:

Dextran 20, Dextran 40, Dextran 70 Series for solution and injection

Iron Dextran Solution 10%, 20%

Iron Dextran for injection



If you are looking for the Dextran 40 and Dextran 20, Dextran 70 Raw Material API for Injection BP, EP, USP CAS 9004-54-0, welcome to contact us. We are one of the leading and professional China manufacturers and suppliers in this field. Competitive price and good after-sale service are available.

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